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Innate Immunity, Toll-Like Receptors, and Atherosclerosis: Mouse Models and Methods

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Toll-Like Receptors

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 517))

Summary

Chronic inflammation and aberrant lipid metabolism represent hallmarks of atherosclerosis. Innate immunity critically depends upon Toll-like receptor (TLR) signalling. Recent data directly implicate signalling by TLR4 and TLR2 in the pathogenesis of atherosclerosis. The role that TLRs play in the pathogenesis of atherosclerosis can be assessed by using several animal models, which provide a double genetic deficiency in TLRs and molecules implicated in the lipid metabolism, such as ApoE or LDL receptor. Furthermore, a more recent technique, such as the bone marrow transplantation (BMT), can be a useful and straightforward method to elucidate the role of stromal versus hematopoietic cells in the acceleration of the atheroma.

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Authors and Affiliations

  1. Division of Pediatric Infectious Diseases and the Atherosclerosis Research Center, Burns and Allen Research Institute, University of California, Los Angeles, USA

    Rosalinda Sorrentino & Moshe Arditi

Authors
  1. Rosalinda Sorrentino
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  2. Moshe Arditi
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Corresponding author

Correspondence to Moshe Arditi .

Editor information

Editors and Affiliations

  1. School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

    Claire E. McCoy  & Luke A. J. O’Neill  & 

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© 2009 Humana Press, a part of Springer Science + Business Media, LLC

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Sorrentino, R., Arditi, M. (2009). Innate Immunity, Toll-Like Receptors, and Atherosclerosis: Mouse Models and Methods. In: McCoy, C.E., O’Neill, L.A.J. (eds) Toll-Like Receptors. Methods in Molecular Biology™, vol 517. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-541-1_23

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  • DOI: https://doi.org/10.1007/978-1-59745-541-1_23

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-934115-72-5

  • Online ISBN: 978-1-59745-541-1

  • eBook Packages: Springer Protocols

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