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MR Spectroscopy and Spectroscopic Imaging of the Brain

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Magnetic Resonance Neuroimaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 711))

Abstract

Magnetic resonance spectroscopy (MRS) and the related technique of magnetic resonance spectroscopic imaging (MRSI) are widely used in both clinical and preclinical research for the non-invasive evaluation of brain metabolism. They are also used in medical practice, although their ultimate clinical value continues to be a source of discussion. This chapter reviews the general information content of brain spectra and commonly used protocols for both MRS and MRSI and also touches on data analysis methods and quantitation. The main focus is on proton MRS for application in humans, but many of the methods are also applicable to other nuclei and studies of animal models as well.

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Acknowledgments

Supported in part by National Institutes of Health grant P41 RR015241.

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Authors and Affiliations

  1. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    He Zhu & Peter B. Barker

  2. The Kennedy Krieger Institute, Baltimore, MD, USA

    Peter B. Barker

Authors
  1. He Zhu
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  2. Peter B. Barker
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Correspondence to Peter B. Barker .

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Editors and Affiliations

  1. Institute of Psychiatry, Department of Neuroscience, King's College London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Michel Modo

  2. Institute of Cell Engineering, Dept Radiology & Radiological Sciences, Johns Hopkins Univ. Sch. of Med., Rutland Ave. 720, Baltimore, 21205, Maryland, USA

    Jeff W.M. Bulte

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Zhu, H., Barker, P.B. (2011). MR Spectroscopy and Spectroscopic Imaging of the Brain. In: Modo, M., Bulte, J. (eds) Magnetic Resonance Neuroimaging. Methods in Molecular Biology, vol 711. Humana Press. https://doi.org/10.1007/978-1-61737-992-5_9

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  • DOI: https://doi.org/10.1007/978-1-61737-992-5_9

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61737-991-8

  • Online ISBN: 978-1-61737-992-5

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