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The Epigenetics of Brain Tumors

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Cancer Epigenetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 863))

Abstract

Glioblastoma, medulloblastoma, and ependymoma represent molecularly and clinically diverse forms of adult and pediatric brain tumors. While each tumor displays genetic, transcriptional, and cytogenetic heterogeneity, the epigenome of these tumors has only recently emerged as a major field of interest. Here, we describe advances in our understanding of the epigenetics of brain tumors, focusing on DNA methylation, histone modifications, and microRNA deregulation which contribute to the pathogenesis of these diseases.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathobiology, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada

    Adrian M. Dubuc, Stephen Mack & Michael D. Taylor

  2. Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada

    Alexander Unterberger & Paul A. Northcott

Authors
  1. Adrian M. Dubuc
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  2. Stephen Mack
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  3. Alexander Unterberger
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  4. Paul A. Northcott
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  5. Michael D. Taylor
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Correspondence to Michael D. Taylor .

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Editors and Affiliations

  1. School of Medicine, Saba University, Saba, Dutch Antilles

    Ramona G. Dumitrescu

  2. National Institutes of Health (NIH), Div. Cancer Control &, National Cancer Institute, Executive Blvd. 6130Suite 5100, Bethesda, 20892-7324, Maryland, USA

    Mukesh Verma

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Dubuc, A.M., Mack, S., Unterberger, A., Northcott, P.A., Taylor, M.D. (2012). The Epigenetics of Brain Tumors. In: Dumitrescu, R., Verma, M. (eds) Cancer Epigenetics. Methods in Molecular Biology, vol 863. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-612-8_8

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  • DOI: https://doi.org/10.1007/978-1-61779-612-8_8

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