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Molecular Typing in Bacterial Infections Haemophilus spp.

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Molecular Typing in Bacterial Infections

Part of the book series: Infectious Disease ((ID))

Abstract

Although immunization of infants with conjugate vaccines against Haemophilus influenzae serotype b (Hib) has dramatically decreased the incidence of invasive Hib disease in developed countries, H. influenzae remains an important human pathogen able to cause respiratory tract disease as well as invasive disease. In the present Hib post-vaccine era, concern about the potential emergence of non-vaccine preventable strains (both encapsulated non-b and nonencapsulated strains) as important pathogens has arisen. The availability of H. influenzae gene sequences and the advancements in DNA-based techniques have made it possible to apply the DNA-based methods for both molecular detection and molecular epidemiology of H. influenzae. This chapter provides an up-to-date look at the principal molecular methods currently used in the study of H. influenzae in view of the major issues raised in the Hib post-vaccine era.

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  1. Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, Rome, 00161, Italy

    Marina Cerquetti

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  1. Marina Cerquetti
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Correspondence to Marina Cerquetti .

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  1. Instituto Nacional de Controle de, Qualidade em Saúde, Fundação Oswaldo Cruz (FIOCRUZ), Av. Brasil 4365, Rio de Janeiro, 21045-900, Rio de Janeiro, Brazil

    Ivano de Filippis

  2. Microbiology, BioReliance Corporation, Broschart Road 14920, Rockville, 20850, Maryland, USA

    Marian L. McKee

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Cerquetti, M. (2013). Molecular Typing in Bacterial Infections Haemophilus spp.. In: de Filippis, I., McKee, M. (eds) Molecular Typing in Bacterial Infections. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-185-1_13

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  • DOI: https://doi.org/10.1007/978-1-62703-185-1_13

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