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Insight into Autonomic Nervous System Control of Heart Rate in the Rat Using Analysis of Heart Rate Variability and Baroreflex Sensitivity

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Stimulation and Inhibition of Neurons

Part of the book series: Neuromethods ((NM,volume 78))

Abstract

Heart rate variability and baroreflex sensitivity are two readily accessible methods available to assess control of heart rate by the autonomic nervous system. Heart rate variability can provide information regarding neural (parasympathetic, sympathetic, reflex) and nonneural (hormones, thermoregulation) control of heart rate. Baroreflex sensitivity provides information on how effective the autonomic nervous system is in rapidly changing heart rate in response to changes in blood pressure. Methods are presented on how to calculate heart rate variability using frequency domain analysis and how to calculate baroreflex sensitivity using the sequence method and α-coefficient method of analysis. Data is presented from a variety of rat strains (control, hypertensive, kidney disease, depressed) to indicate the utility of these methods for comparing autonomic regulation of the heart in both anaesthetised animals via intra-arterial recordings and conscious animals using telemetry.

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Author information

Authors and Affiliations

  1. Australian School of Advanced Medicine, Macquarie University, North Ryde, NSW, Australia

    Cara M. Hildreth, Ann K. Goodchild & Jacqueline K. Phillips

Authors
  1. Cara M. Hildreth
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  2. Ann K. Goodchild
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  3. Jacqueline K. Phillips
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Corresponding author

Correspondence to Cara M. Hildreth .

Editor information

Editors and Affiliations

  1. , Australian School of Advanced Medicine, Macquarie University, Technology Place 2, North Ryde, 2113, New South Wales, Australia

    Paul M. Pilowsky

  2. , Australian School of Advanced Medicine, Macquarie University, Technology Place 2, North Ryde, 2113, New South Wales, Australia

    Melissa M.J. Farnham

  3. , Australian School of Advanced Medicine, Macquarie University, Technology Place 2, North Ryde, 2113, New South Wales, Australia

    Angelina Y. Fong

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Hildreth, C.M., Goodchild, A.K., Phillips, J.K. (2013). Insight into Autonomic Nervous System Control of Heart Rate in the Rat Using Analysis of Heart Rate Variability and Baroreflex Sensitivity. In: Pilowsky, P., Farnham, M., Fong, A. (eds) Stimulation and Inhibition of Neurons. Neuromethods, vol 78. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-233-9_12

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  • DOI: https://doi.org/10.1007/978-1-62703-233-9_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-232-2

  • Online ISBN: 978-1-62703-233-9

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