Abstract
Certain lymphoma types are characterized by recurring genetic translocations. Detection of these translocations enables confirmation of a suspected diagnosis and provides a genetic marker which can be subsequently monitored and followed. Rapid and reliable identification of these molecular rearrangements is a key component in the workup of lymphoma. While conventional cytogenetics may be a useful tool in this regard, fluorescence in situ hybridization (FISH) offers additional advantages including the ability to use formalin-fixed tissues, no requirement for dividing cells, ability to score many cells, improved sensitivity, and faster turnaround time for results.
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Reichard, K.K., Robinett, S. (2013). Detection of Genetic Translocations in Lymphoma Using Fluorescence In Situ Hybridization. In: Czader, M. (eds) Hematological Malignancies. Methods in Molecular Biology, vol 999. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-357-2_12
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DOI: https://doi.org/10.1007/978-1-62703-357-2_12
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-62703-356-5
Online ISBN: 978-1-62703-357-2
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