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Limbal Epithelial Cell Therapy: Past, Present, and Future

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Corneal Regenerative Medicine

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1014))

Abstract

The cornea, the clear window at the front of the eye, transmits light to the retina to enable vision. The corneal surface is renewed by stem cells located at the peripheral limbal region. These cells can be destroyed by a number of factors, including chemical burns, infections, and autoimmune diseases, which result in limbal stem cell deficiency (LSCD), a condition that can lead to blindness. Established therapy for LSCD based on ex vivo expanded limbal epithelial cells is currently at a stage of refinement. Therapy for LSCD is also rapidly evolving to include alternative cell types and clinical approaches as treatment modalities. In the present perspectives chapter, strategies to treat LSCD are discussed and advances in this important field of regenerative medicine are highlighted.

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Acknowledgements

The authors thank Astrid Østerud at the Department of Ophthalmology, Oslo University Hospital, Norway; Ingrid Riphagen at the Unit for Applied Clinical Research, Norwegian University of Science and Technology, Norway; Sten Ræder at the Department of Ophthalmology, Stavanger University Hospital, Stavanger, Norway, and SynsLaser kirurgi, Oslo/Tromsø, Norway; and Øygunn Aass Utheim and Torstein Lyberg at the Department of Medical Biochemistry, Oslo University Hospital, Norway for excellent help and support.

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  1. Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway

    Tor Paaske Utheim

  2. Schepens Eye Research Institute, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA

    Tor Paaske Utheim

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  1. School of Pharmacy, University of Reading, Shinfield Road, Reading, RG6 6UB, United Kingdom

    Bernice Wright

  2. School of Pharmacy, University of Reading, Shinfield Road, Reading, RG6 6UB, United Kingdom

    Che J Connon

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Utheim, T.P. (2013). Limbal Epithelial Cell Therapy: Past, Present, and Future. In: Wright, B., Connon, C. (eds) Corneal Regenerative Medicine. Methods in Molecular Biology, vol 1014. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-432-6_1

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  • DOI: https://doi.org/10.1007/978-1-62703-432-6_1

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