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Some Observations About the Origin of the Pain in Cluster Headache

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Cluster Headache and other Trigeminal Autonomic Cephalgias

Part of the book series: Headache ((HEAD))

Abstract

Given the clinical presentation and neuroscientific evidence, it is undisputed that the hypothalamus plays a central role in cluster headache (CH) pathogenesis [1, 2]. But does an activation of the hypothalamus suffice in generating the perception of pain or are peripheral structures required? This chapter revolves around the question of nociceptive input: where does the pain in CH originate from? This is a question which, as of yet, has no conclusive answer [2–5]. However, looking at previous research and clinical observations, we might be able to make some assumptions and pose some qualified guesses.

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Authors and Affiliations

  1. Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

    Trine Nielsen & Arne May

  2. Department of Neurology, University Medical Center Rostock, Rostock, Germany

    Tim P. Jürgens

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  1. Trine Nielsen
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  2. Arne May
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  3. Tim P. Jürgens
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Correspondence to Trine Nielsen .

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Editors and Affiliations

  1. Department of Neurology, Neuroalgology Unit, The Foundation of the Carlo Besta Neurological Institute, IRCCS, Milano, Italy

    Massimo Leone

  2. Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany

    Arne May

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Nielsen, T., May, A., Jürgens, T.P. (2020). Some Observations About the Origin of the Pain in Cluster Headache. In: Leone, M., May, A. (eds) Cluster Headache and other Trigeminal Autonomic Cephalgias. Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-12438-0_8

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  • DOI: https://doi.org/10.1007/978-3-030-12438-0_8

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