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Relevance of CTC Clusters in Breast Cancer Metastasis

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Circulating Tumor Cells in Breast Cancer Metastatic Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1220))

Abstract

Metastasis is the major cause of mortality in patients with breast cancer; however, the mechanisms of tumor cell dissemination and metastasis formation are not well established yet. The study of circulating tumour cells (CTCs), the metastatic precursors of distant disease, may help in this search. CTCs can be found in the blood of cancer patients as single cells or as tumor cell aggregates, known as CTC clusters. CTC clusters have differential biological features such as an enhanced survival and metastatic potential, and they hold great promises for the evaluation of prognosis, diagnosis and therapy of the metastatic cancer. The analysis of CTC clusters offers new insights into the mechanism of metastasis and can guide towards the development of new diagnostic and therapeutic strategies to suppress cancer metastasis. This has become possible thanks to the development of improved technologies for detection of CTCs and CTC clusters. However, more efficient methods are needed in order to address important questions regarding the metastatic potential of CTC and future clinical applications. In this chapter, we explore the current knowledge on the role of CTC clusters in breast cancer metastasis, their origin, metastatic advantages and clinical importance.

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Acknowledgements

The work of the authors is supported by Roche-Chus Joint Unit (IN853B 2018/03) funded by GAIN, “Consellería de Economía, Emprego e Industria”. IMP is funded by the Training Programme for Academic Staff (FPU) fellowship, from the Ministry of Education and Vocational Training, Spanish Government.

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  1. Roche-Chus Joint Unit, Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain

    Roberto Piñeiro & Inés Martínez-Pena

  2. Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago de Compostela, University Clinical Hospital of Santiago de Compostela (CHUS/SERGAS), Santiago de Compostela, Spain

    Rafael López-López

  3. Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain

    Rafael López-López

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    Roberto Piñeiro

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Piñeiro, R., Martínez-Pena, I., López-López, R. (2020). Relevance of CTC Clusters in Breast Cancer Metastasis. In: Piñeiro, R. (eds) Circulating Tumor Cells in Breast Cancer Metastatic Disease. Advances in Experimental Medicine and Biology, vol 1220. Springer, Cham. https://doi.org/10.1007/978-3-030-35805-1_7

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