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What Is the Meaning of an Oxygen Measurement?

Analysis of Methods Purporting to Measure Oxygen in Targeted Tissues

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Oxygen Transport to Tissue XLII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1269))

Abstract

Clinical measurements of O2 in tissues will inevitably provide data that are at best aggregated and will not reflect the inherent heterogeneity of O2 in tissues over space and time. Additionally, the nature of all existing techniques to measure O2 results in complex sampling of the volume that is sensed by the technique. By recognizing these potential limitations of the measures, one can focus on the very important and useful information that can be obtained from these techniques, especially data about factors that can change levels of O2 and then exploit these changes diagnostically and therapeutically. The clinical utility of such data ultimately needs to be verified by careful studies of outcomes related to the measured changes in levels of O2.

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Notes

  1. 1.

    These synonyms are from the thesaurus with Word.

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Acknowledgments

Major funding is from the National Cancer Institute, PPG Grant P01CA190193. We gratefully acknowledge all the other scientists, clinicians, engineers, and coordinators on the PPG. Disclaimer: HMS and ABF are owners of Clin-EPR, LLC, which manufacturers clinical EPR instruments for investigational use only.

Author information

Authors and Affiliations

  1. Department of Radiology, Dartmouth Medical School, Hanover, NH, USA

    Harold M. Swartz & Ann Barry Flood

  2. Department of Radiation Oncology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    Harold M. Swartz, Benjamin B. Williams & Philip E. Schaner

  3. Thayer School of Engineering, Dartmouth College, Hanover, NH, USA

    Harold M. Swartz & Brian W. Pogue

  4. Department of Radiation Oncology, University Medical Center, University of Freiburg, Freiburg, Germany

    Peter Vaupel

Authors
  1. Harold M. Swartz
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  2. Ann Barry Flood
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  3. Benjamin B. Williams
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  4. Brian W. Pogue
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  5. Philip E. Schaner
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  6. Peter Vaupel
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Corresponding author

Correspondence to Harold M. Swartz .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of New Mexico, Albuquerque, NM, USA

    Edwin M. Nemoto

  2. Bozen, Italy

    Eileen M. Harrison

  3. Department of Chemistry, New Mexico Institute of Mining and Technology (New Mexico Tech), Socorro, NM, USA

    Sally C. Pias

  4. Lovelace Biomedical Research Institute, Albuquerque, NM, USA

    Denis E. Bragin

  5. St. Lorenzen, Italy

    David K. Harrison

  6. Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Joseph C. LaManna

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Swartz, H.M., Flood, A.B., Williams, B.B., Pogue, B.W., Schaner, P.E., Vaupel, P. (2021). What Is the Meaning of an Oxygen Measurement?. In: Nemoto, E.M., Harrison, E.M., Pias, S.C., Bragin, D.E., Harrison, D.K., LaManna, J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_48

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