Abstract
In this paper, we consider densely connected convolutional networks and their applicability to the problem of assessment of knee osteoarthritis (OA) severity in the five-point Kellgren-Lawrence scale. First, we use trained from scratch Single Shot Detector (SSD) to localize knee joint areas in radiographs. Then, we apply DenseNets to quantify OA stages in the images of detected knee joints. We consider networks of different depths, trained both from scratch and pre-trained on the ImageNet dataset and fine-tuned in the images from Osteoarthritis Initiative dataset (OAI). Also, different loss functions are examined to understand which one gives the best training results. In the knee joint localization task, we obtain an accuracy of 94.03% under the Jaccard index threshold of 0.75. Also, our classifier outperforms the current state-of-the-art with accuracy of 71% in the classification task.
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References
Kellgren, J., Lawrence, J.: Radiological assessment of osteo-arthrosis. Ann. Rheum. Dis. 16, 494–502 (1957)
Schiphof, D., Boers, M., Bierma-Zeinstra, S.: Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis. Ann. Rheum. Dis. 67, 1034–1036 (2008)
Altman, R., Gold, G.: Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthr. Cartil. 15(Suppl A), A1–A56 (2007)
Altman, R., Asch, E., Bloch, D., Bole, G., Borenstein, D., Brandt, K., et al.: Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum. 29, 1039–1049 (1986)
Culvenor, A., Engen, C., Engebretsen, L., Risberg, M.: Defining the presence of radiographic knee osteoarthritis: a comparison between the Kellgren and Lawrence system and OARSI atlas criteria. Osteoarthr. Cartil. (22), 265 (2014)
Sheehy, L.: Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the multicenter osteoarthritis study (MOST). Osteoarthr. Cartil. 23, 1491–1498 (2015)
Chan, S., Dittakan, K.: Osteoarthritis stages classification to human joint imagery using texture analysis: a comparative study on ten texture descriptors. In: Santosh, K.C., Hegadi, R.S. (eds.) RTIP2R 2018. CCIS, vol. 1036, pp. 209–225. Springer, Singapore (2019). https://doi.org/10.1007/978-981-13-9184-2_19
Minciullo, L., Cootes, T.: Fully automated shape analysis for detection of Osteoarthritis from lateral knee radiographs. In: 23rd International Conference on Pattern Recognition (ICPR), pp. 3787–3791 (2016)
Antony, J., McGuinness, K., Moran, K., O’Connor, N.: Automatic detection of knee joints and quantification of knee osteoarthritis severity using convolutional neural networks. arXiv:1703.09856 [cs.CV], 29 March 2017
Antony, J., McGuinness, K., Moran, K., O’Connor, N.: Quantifying radiographic knee osteoarthritis severity using deep convolutional neural networks. arXiv:1609.02469 [cs.CV], 8 September 2016
Pingjun, C., Linlin, G., Xiaoshuang, S., Kyle, A., Lin, Y.: Fully automatic knee osteoarthritis severity grading using deep neural networks with a novel ordinal loss. Comput. Med. Imaging Graph. 75, 84–92 (2019). https://doi.org/10.1016/j.compmedimag.2019.06.002
Tiulpin, A., Thevenot, J., Rahtu, E., Saarakkala, S.: A novel method for automatic localization of joint area on knee plain radiographs. In: Sharma, P., Bianchi, F.M. (eds.) SCIA 2017. LNCS, vol. 10270, pp. 290–301. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-59129-2_25
Hu, J., Shen, L., Sun, G.: Squeeze-and-excitation networks. In: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 7132–7141 (2018)
Tiulpin, A., Saarakkala, S.: Automatic grading of individual knee osteoarthritis features in plain radiographs using deep convolutional neural networks. arXiv:1907.08020, Image and Video Processing (2019)
Tiulpin, A., Thevenot, J., Rahtu, E., Lehenkari, P., Saarakkala, S.: Automatic knee osteoarthritis diagnosis from plain radiographs: a deep learning-based approach. arXiv:1710.10589 [cs.CV], 29 October 2017
Norman, B.D., Pedoia, V., Noworolski, A., Link, T.M., Majumdar, S.: Automatic knee Kellgren Lawrence grading with artificial intelligence. Osteoarthr. Cartil. 26, S436–S437 (2018)
Anifah, L., Purnama, I.K., Hariadi, M., Purnomo, M.H.: Osteoarthritis classification using self organizing map based on Gabor kernel and contrast-limited adaptive histogram equalization. Open Biomed. Eng. J. 7, 18–28 (2013). https://doi.org/10.2174/1874120701307010018
Wahyuningrum, R.T., Anifah, L., Purnama, I.K., Purnomo, M.H.: A new approach to classify knee osteoarthritis severity from radiographic images based on CNN-LSTM method. In: 2019 IEEE 10th International Conference on Awareness Science and Technology (iCAST), pp. 1–6 (2019). https://doi.org/10.1109/ICAwST.2019.8923284
Norman, B., Pedoia, V., Noworolski, A., et al.: Applying densely connected convolutional neural networks for staging osteoarthritis severity from plain radiographs. J. Digit. Imaging 32, 471–477 (2019). https://doi.org/10.1007/s10278-018-0098-3
Ren, S., He, K., Girshick, R., Sun, J.: Faster R-CNN: towards real-time object detection with region proposal networks. IEEE Trans. Pattern Anal. Mach. Intell. 39, 1137–1149 (2017). https://doi.org/10.1109/TPAMI.2016.2577031
Liu, B., Luo, J., Huang, H.: Toward automatic quantification of knee osteoarthritis severity using improved Faster R-CNN. Int. J. Comput. Assist. Radiol. Surg. 15, 457–466 (2020). https://doi.org/10.1007/s11548-019-02096-9
Liu, W., et al.: SSD: single shot MultiBox detector. In: Leibe, B., Matas, J., Sebe, N., Welling, M. (eds.) ECCV 2016. LNCS, vol. 9905, pp. 21–37. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46448-0_2
Szegedy, C., Liu, W., Jia, Y., Sermanet, P., et al.: Going deeper with convolutions. arXiv:1409.4842 [cs.CV], 17 September 2014
Howard, A.G., Zhu, M., Chen, B., Kalenichenko, D., et al.: MobileNets: efficient convolutional neural networks for mobile vision applications. arXiv:1704.04861, Computer Vision and Pattern Recognition (2017)
Huang, G., Liu, Z., Weinberger, K.Q.: Densely connected convolutional networks. arXiv:1608.06993 [cs.CV], 28 January 2018
Cheng, J., Aurélien, B., Mark, L.: The relative performance of ensemble methods with deep convolutional neural networks for image classification. J. Appl. Stat. 45, 2800–2818 (2018). https://doi.org/10.1080/02664763.2018.1441383
Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv:1412.6980 [cs.LG] (2014)
Selvaraju, R.R., Cogswell, M., Das, A., et al.: Grad-CAM: visual explanations from deep networks via gradient-based localization. In: 2017 IEEE International Conference on Computer Vision (ICCV), pp. 618–626 (2017). https://doi.org/10.1109/ICCV.2017.74
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Mikhaylichenko, A., Demyanenko, Y. (2021). Automatic Grading of Knee Osteoarthritis from Plain Radiographs Using Densely Connected Convolutional Networks. In: van der Aalst, W.M.P., et al. Recent Trends in Analysis of Images, Social Networks and Texts. AIST 2020. Communications in Computer and Information Science, vol 1357. Springer, Cham. https://doi.org/10.1007/978-3-030-71214-3_13
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