Summary
Protective activity of (-) nicotine on l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine-induced (MPTP, 50 mg/kg sc) neurotoxicity is demonstrated in the mesostriatal dopamine (DA) system in the male black mouse with an acute intermittent (-)nicotine treatment (0.5 mg/kg x 4, starting immediately following the MPTP injection with a 30-minute time interval) together with a two-week continuous administration of (-) nicotine via Alzet minipumps implanted subcutaneously the day before MPTP is given. In contrast, when omitting the acute (-) nicotine treatment a dose-dependent increase in the MPTP-induced neurotoxicity is seen.
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© 1991 Birkhäuser Verlag Basel
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Janson, A.M., Fuxe, K., Agnati, L.F., Sundström, E., Goldstein, M. (1991). The Effect of Chronic Nicotine Treatment on 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Degeneration of Nigrostriatal Dopamine Neurons in the Black Mouse. In: Adlkofer, F., Thurau, K. (eds) Effects of Nicotine on Biological Systems. APS Advances in Pharmacological Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7457-1_42
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DOI: https://doi.org/10.1007/978-3-0348-7457-1_42
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