Summary
The dopamine transporter (DAT) is a transmembrane spanning protein that catalyzes the transport of dopamine across the neuronal membrane to concentrate the neurotransmitter inside the cell. Although the uptake of dopamine has been studied since the 1960s, more recent advances in knowledge of the protein itself and in making kinetically resolved measurements of its action have led to more insights into its mechanism and pharmacology. The literature of the kinetics of transporters and kinetic measurements of DAT activity is reviewed to provide an overview of the multisubstrate mechanism of DAT activity, its pharmacology with regard to amphetamine, cocaine and methylphenidate, and correlations of DAT activity with some behavioral outputs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.S. Horn: Prog. Neurobiol.34387 (1990).
A. Horn, in: D. Paton (ed.): The mechanism of neuronal and extraneuronal transport of catecholamines, Raven Press, New York 1976, 195.
A.S. Horn: Adv. Biochem. Psychopharmacol.1925 (1978).
D. Patton (ed.): The mechanism of neuronal and extraneuronal transport of catecholamines, Raven Press, New York 1976.
T. Alexi, C.V. Borlongan, R.L.M. Faull, C.E. Williams, R.G. Clark, P.D. Gluckman and P.E. Hughes: Progr. Neurobiol.60409 (2000).
J. Ball: Trends Neurosci.24367 (2001).
M.C. Ritz, R.J. Lamb, S.R. Goldberg, and M.J. Kuhar: Science2371219 (1987).
M.J. Kuhar, M.C. Ritz and J. Sharkey: NIDA. Research Monograph8814 (1988).
M.C. Ritz, R.J. Lamb, S.R. Goldberg and M.J. Kuhar: Prog. Neuro-psychopharmacol. Biol. Psychiatry.12233 (1988).
S.G. Amara and M.J. Kuhar: Annu. Rev. Neurosci.1673 (1993).
S.G. Amara and M.S. Sonders: Drug Alcohol. Depend.5187 (1998).
S.G. Amara, M.S. Sonders, N.R. Zahniser, S.L. Povlock and G.M. Daniels: Adv. Pharmacol.42164 (1998).
S.L. Povlock and J.O. Schenk: J. Neurochem.691093 (1997).
J.S. McElvain and J.O. Schenk: Biochem. Pharmacol.432189 (1992).
N. Chen and M.E. Reith: Eur. J. Pharmacol.405329 (2000).
M.E. Reith, C. Xu and N.H. Chen: Eur. J. Pharmacol.3241 (1997).
B. Olivier, W. Soudijn and I. van. Wijngaarden: Prog. Drug. Res.5459 (2000).
M.A. Bunin and R.M. Wightman: Meth. Enzymol.296689 (1998).
N.-H. Chen and M.E.A. Reith: Meth. Enzymol.296719 (1998).
M.A. Bunin and R.M. Wightman: Meth. Enzymol.296689 (1998).
N.R. Zahniser, S.D. Dickinson and G.A. Gerhardt: Meth. Enzymol.296708 (1998).
R.P. Hammer (ed.): The neurobiology of cocaine: cellular and molecular mechanisms, CRC Press, Boca Raton 1995.
S.L. Povlock, S.M. Meiergerd and J.O. Schenk, in: T.W. Stone (ed.): CNS neurotransmitters and neuromodulators: dopamine, CRC Press, Boca Raton 1996, 21–39.
B.C. Fisher: Attention deficit disorder misdiagnosis. Approaching ADD from a brainbehavior/neuropsychological. Perspective for assessment and treatment. CRC Press, Boca Raton 1998.
H. Schubiner, A. Tzelepis, J.H. Isaacson and L. Warbasse: J. Clin. Psychiatry56146 (1995).
S.M. Meiergerd, J.O. Schenk and B.A. Sorg: Brain Res.773203 (1997).
S.M. Meiergerd, J.S. McElvain and J.O. Schenk: Biochem. Pharmacol.471627 (1994).
S.M. Meiergerd, S.M. Hooks and J.O. Schenk: J. Neurochem.631277 (1994).
J.C. Eccles and J.C. Jaeger: Proc. Royal. Soc. (B) (London)14838 (1956).
P.A. Garris and R.M. Wightman: J. Neurosci.14442 (1994).
J.O. Schenk and B.S. Bunney: Quantitative interpretations ofin vivochronoamperometry: clues toward understanding the spatial and temporal influences of dopamine, in: J.B. Justice (ed.): Voltammetry in the neurosciences, Humana Press, Clifton 1987, 139–160.
M.J. Kuhar and M.A. Zarbin: J. Neurochem.31251 (1978).
J.E. Harris and R.J. Baldessarini: Life. Sci. 13303(1973).
B. Giros and M.G. Caron: Trends Pharmacol. Sci.1443 (1993).
B. Giros, Y.M. Wang, S. Suter, S.B. McLeskey, C. Pifl and M.G. Caron: J. Biol. Chem.26915985 (1994).
B. Giros, S. el Mestikawy, L. Bertrand and M.G. Caron: FEBS Lett.295149 (1991).
R. Lew, D. Grigoriadis, A. Wilson, J.W. Boja, R. Simantov and M.J. Kuhar: Brain Res.539239 (1991).
R. Lew, R. Vaughan, R. Simantov, A. Wilson and M.J. Kuhar: Synapse (New York, N.Y.).8152 (1991).
R. Lew, A. Patel, R.A. Vaughan, A. Wilson and M.J. Kuhar: Brain Res.584266 (1992).
S.J. Zhu, M.P. Kavanaugh, M.S. Sonders, S.G. Amara and N.R. Zahniser: J. Pharmacol. Exp. Ther.2821358 (1997).
G.M. Daniels and S.G. Amara: J. Biol. Chem.27435794 (1999).
M. Batchelor and J.O. Schenk: J. Neurosci.1810304 (1998).
C.J. Loland, L. Norregaard, T. Litman and U. Gether: Proc. Natl. Acad. Sci. USA991683 (2002).
U. Gether, L. Norregaard and C.J. Loland: Life Sci.682187 (2001).
L. Norregaard, I. Visiers, C.J. Loland, J. Ballesteros, H. Weinstein and U. Gether: Biochemistry3915836 (2000).
C.J. Loland, L. Norregaard and U. Gether: J. Biol. Chem. 274, 36928 (1999).
L. Norregaard, D. Frederiksen, E.O. Nielsen and U. Gether: Embo J. 174266 (1998).
S.G. Amara (ed.): Neurotransmitter transporters, Academic Press, San Diego 1998.
G.L. Amidon and W. Sadee (eds.): Membrane transporters as drug targets, Pharmaceut. Biotechnol.121999.
R. Devés and R.M. Krupka: Meth. Enzymol.171113 (1989).
W.D. Stein: Transport and diffusion across cell membranes. Harcourt Brace Jovanovitch, Academic Press, San Diego 1986.
W.D. Stein: Channels, carriers and pumps: an introduction to membrane transport, Academic Press, Harcourt Brace Jovanovitch, San Diego 1990.
T.F. Weiss: Cellular biophysics, Vol. 1: Transport, A Bradford Book, The MIT Press, Cambridge, MA 1996.
H. Wayment, S.M. Meiergerd and J.O. Schenk: J. Neurochem.701941 (1998).
R. Niddam, S. Arbilla, B. Scatton, T. Dennis and S.Z. Langer: Naunyn Schmiedebergs Arch. Pharmacol.329123 (1985).
S.M. Meiergerd and J.O. Schenk, in: A. Boulton, G. Baker and R.N. Adams (eds.): Neuromethods, Vol. 27: Voltammetric methods in brain systems, Humana Press, Totowa 1997, 305–337.
C. Earles, H. Wayment, M. Green and J.O. Schenk: Meth. Enzymol.296660 (1998).
C. Earles and J.O. Schenk: Anal. Biochem.264191 (1998).
R.D. Blakely, M.B. Robinson and S.G. Amara: Proc. Natl. Acad. Sci. USA859846 (1988).
H.H. Sitte, S. Huck, H. Reither, S. Boehm, E.A. Singer and C. Pifl: J. Neurochem.711289 (1998).
M.S. Sonders, S.J. Zhu, N.R. Zahniser, M.P. Kavanaugh and S.G. Amara: J. Neurosci.17960 (1997).
J.L. Berfield, L.C. Wang and M.E. Reith: J. Biol. Chem.2744876 (1999).
A.S. Horn: J. Pharm. Pharmacol.26735 (1974).
A.S. Horn and S.H. Snyder: J. Pharmacol. Exp. Ther.180523 (1972).
S.M. Meiergerd and J.O. Schenk: J. Neurochem.62998 (1994).
C.J. Cao, M.M. Young, J.B. Wong, L.G. Mahran and M.E. Eldefrawi: Membr. Biochem.8207 (1989).
H. Hastrup, A. Karlin and J.A. Javitch: Proc. Natl. Acad. Sci. USA9810055 (2001).
R.E. Whitehead, J.V. Ferrer, J.A. Javitch and J.B. Justice: J. Neurochem.761242 (2001).
I.H. Segel: Enzyme kinetics: behavior and analysis of rapid equilibrium and steady state enzyme systems. John Wiley & Sons, Inc., New York 1975.
H.J. Fromm: Initial rate enzyme kinetics. Springer-Verlag, New York 1975.
R. Devés, in: Z.I. Cabantchik (ed.): Cell membrane transport: experimental approaches and methodologies, Plenum Press, New York 1991.
S. Fleischer and B. Fleischer (eds.): Biomembranes (Part R: Transport theory: cells and model membranes), Academic Press, San Diego 1989.
D.L. Yudilevich, R. Devés, S. Peran and Z.I. Cabantchik (eds.): Cell membrane transport: experimental approaches and methodologies, Plenum Press, New York 1991.
D.D. Wheeler, A.M. Edwards, B.M. Chapman and J.G. Ondo: Neurochem. Res.1949 (1994).
D.D. Wheeler, A.M. Edwards and J.G. Ondo: Neuropharmacology32501 (1993).
D.D. Wheeler, A.M. Edwards, B.M. Chapman and J.G. Ondo: Neurochem. Res.18927 (1993).
N. Amejdki-Chab, S. Benmansour, J. Costentin and J.J. Bonnet: J. Neurochem.591795 (1992).
N. Amejdki-Chab, J. Costentin and J.J. Bonnet: J. Neurochem.58793 (1992).
H.K. Wayment, J.O. Schenk and B.A. Sorg: J. Neurosci.2135 (2001).
C. Earles and J.O. Schenk: Synapse33230 (1999).
N. Chen, C.G. Trowbridge and J.B. Justice Jr.: J. Pharmacol. Exp. Ther.290940 (1999).
E.H. Petrali, A.A. Boulton and L.E. Dyck: Neurochem. Res.4633 (1979).
R. Zaczek, S. Culp, H. Goldberg, D.J. McCann and E.B. De. Souza: J. Pharmacol. Exp. Ther.257820 (1991).
R. Zaczek, S. Culp and E.B. De. Souza: J. Pharmacol. Exp. Ther.257830 (1991).
N.Y. Liang and C.O. Rutledge: Biochem. Pharmacol.31983 (1982).
J.W. Boja, F.I. Carroll, M.A. Rahman, A. Philip, A.H. Lewin and M.J. Kuhar: Eur. J. Pharmacol.184329 (1990).
J.W. Boja, R.M. McNeill, A.H. Lewin, P. Abraham, F.I. Carroll and M.J. Kuhar: Neuroreport3984 (1992).
C. Missale, L. Castelletti, S. Govoni, P.F. Spano, M. Trabucchi and I. Hanbauer: J. Neurochem.4551 (1985).
N. Chen and J.B. Justice Jr.: J. Neurosci.1810257 (1998).
H.K. Wayment, H. Deutsch, M.M. Schweri and J.O. Schenk: J. Neurochem.721266 (1999).
R. Devés and K.R.M. Devés: J. Biol. Chem.25511870 (1980).
S.M. Meiergerd and J.O. Schenk: J. Neurochem.631683 (1994).
S.M. Hooks, J.L. Juncos, J.B. Justice, S.M. Meiergerd, S.L. Poviock, J.O. Schenk and P.W. Kalivas: J. Neurosci.146144 (1994).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Basel AG
About this chapter
Cite this chapter
Schenk, J.O. (2002). The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 59. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8171-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-0348-8171-5_4
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9464-7
Online ISBN: 978-3-0348-8171-5
eBook Packages: Springer Book Archive