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Lymphangiogenesis: Mechanisms, significance and clinical implications

  • Chapter
Regulation of Angiogenesis

Part of the book series: Experientia Supplementum ((EXS,volume 79))

Abstract

Great attention has been directed toward understanding angiogenesis over the past several decades since this phenomenon was reproduced in vitro in endothelial cell and mixed vascular tissue cultures (Folkman and Hauden-schild, 1980; Folkman, 1995). The focus, however, has been almost entirely on blood vessel growth, or what we have termed “hemangiogenesis” (M. Witte and Witte, 1987 c). Yet a vast interstitial fluid circulation suffuses the tissues, bathes the parenchymal cells and interconnects with the blood vasculature via the lymphatic vasculature (Fig. 1). This arc of the circulatory system on the dark side of the blood-tissue interface and its growth (“lymphangiogenesis”) has received scant attention even though lymphatic (re)generation is both vigorous and essential, and disorders of lymphatic dynamics are common, often disfiguring, and occasionally life- and limb-threatening.

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  1. Department of Surgery, University of Arizona College of Medicine, Tucson, Arizona, 85724, USA

    M. H. Witte, D. L. Way, C. L. Witte & M. Bernas

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  1. Department of Radiation Oncology, Long Island Jewish Medical Center, 270-05 76th Avenue New Hyde Park, 11042, New York, NY, USA

    Itzhak D. Goldberg M.D.  & Eliot M. Rosen M.D. Ph.D.  & 

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Witte, M.H., Way, D.L., Witte, C.L., Bernas, M. (1997). Lymphangiogenesis: Mechanisms, significance and clinical implications. In: Goldberg, I.D., Rosen, E.M. (eds) Regulation of Angiogenesis. Experientia Supplementum, vol 79. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9006-9_5

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