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Role of statins in cerebral vasospasm

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Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 104))

Abstract

3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, commonly known as statins, are widely used clinically for their lipid lowering properties. Recent evidence shows that statins are also effective in ameliorating cerebral vasospasm, which occurs as sequelae of subarachnoid haemorrhage. This review focuses on the pleiotropic effects of statins, and the putative mechanisms involved in statin mediated attenuation of cerebral vasospasm.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Loma Linda University Medical School, Loma Linda, California, USA

    T. Sugawara, R. Ayer & John H. Zhang

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  1. T. Sugawara
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  2. R. Ayer
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  3. John H. Zhang
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Correspondence to John H. Zhang .

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Editors and Affiliations

  1. Department of Neurosurgery, Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey

    Talat Kırış

  2. Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, USA

    John H. Zhang

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© 2008 Springer-Verlag

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Sugawara, T., Ayer, R., Zhang, J.H. (2008). Role of statins in cerebral vasospasm. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_59

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  • DOI: https://doi.org/10.1007/978-3-211-75718-5_59

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-75717-8

  • Online ISBN: 978-3-211-75718-5

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