Background The inflammatory response may contribute to cerebral edema, increased intracranial pressure and cellular loss in traumatic brain injury (TBI). Cytokines are biomarkers of this inflammatory response and new methods allow simultaneous measurement of multiple cytokines.
Methods We examined the IL-1β, IL-6, IL-8 and IL-12, TNFα, and IL-10 in arterial and jugular blood as well as cerebrospinal fluid in patients with severe traumatic brain injury.
Findings Multiple cytokines, particularly pro-inflammatory cytokines, are up-regulated following TBI. Cerebrospinal fluid and arteriovenous differences of some of the cytokines suggest production within the central nervous system. Antiinflammatory cytokines are not up-regulated.
Conclusions Cytokine up-regulation may contribute to the neuroinflammatory reaction that follows traumatic brain injury and may contribute to secondary injury.
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References
Brambilla R, Bracchi-Ricard V, Bethea JR (2006) Cytokines in brain trauma and spinal cord injury. In: Ransohoff RM, Beneviste EN (eds) Cytokines and the CNS, 2nd Edition. CRC Press, New York, pp 299–326
Lenzlinger PM, Morganti-Kossmann MC, Laurer HL, McIntosh TK (2001) The duality of the inflammatory response to traumatic brain injury. Mol Neurobiol 24(1–3):169–181
Maier B, Laurer HL, Rose S, Buurman WA, Marzi I (2005) Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: a normative study. J Neurotrauma 22(7):822–835
Morganti-Kossmann MC, Rancan M, Otto VI, Stahel PF, Kossmann T (2001) Role of cerebral inflammation after traumatic brain injury: a revisited concept. Shock 16(3):165– 177
Raghupathi R, McIntosh TK, Smith DH (1995) Cellular responses to experimental brain injinjury. Brain Pathol 5(4): 437–442
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Goodman, J.C., Van, M., Gopinath, S.P., Robertson, C.S. (2008). Pro-inflammatory and pro-apoptotic elements of the neuroinflammatory response are activated in traumatic brain injury. In: Steiger, H.J. (eds) Acta Neurochirurgica Supplements. Acta Neurochirurgica Supplementum, vol 102. Springer, Vienna. https://doi.org/10.1007/978-3-211-85578-2_85
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DOI: https://doi.org/10.1007/978-3-211-85578-2_85
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