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Notch Signaling and Ageing

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GeNeDis 2014

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 822))

Abstract

Notch signaling is a master controller of the neural stem cell and neural development maintaining a significant role in the normal brain function. Notch genes are involved in embryogenesis, nervous system, and cardiovascular and endocrine function. On the other side, there are studies representing the involvement of Notch mutations in sporadic Alzheimer disease, other neurodegenerative diseases such as Down syndrome, Pick’s and Prion’s disease, and CADASIL. This manuscript attempts to present a holistic view of the positive or negative contribution of Notch signaling in the adult brain, and at the same time to present and promote the promising research fields of study.

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Acknowledgments

This study is funded by the Clinical and system—omics for the identification of the Molecular Determinants of established Chronic Kidney Disease (Project acronym: iMODE-CKD). Grant number: 608332. Seventh Framework Programme FP7.

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Authors and Affiliations

  1. Bioinformatics and Medical Informatics Team, Biomedical Research Foundation, Academy of Athens, Soranou Efessiou 4, Athens, 11527, Greece

    Eleftheria Polychronidou, Dimitrios Vlachakis & Sophia Kossida

  2. Department of Informatics, Ionian University, Corfu, Greece

    Panayiotis Vlamos

  3. Protein Chemistry/Proteomics Unit, Biomedicum Helsinki, Institute of Helsinki, 36, Helsinki, Finland

    Marc Baumann

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  1. Eleftheria Polychronidou
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  2. Dimitrios Vlachakis
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  5. Sophia Kossida
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Correspondence to Sophia Kossida .

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  1. Department of Informatics, Ionian University, Corfu, Greece

    Panayiotis Vlamos

  2. Department of Informatics, Ionian University, Corfu, Greece

    Athanasios Alexiou

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Polychronidou, E., Vlachakis, D., Vlamos, P., Baumann, M., Kossida, S. (2015). Notch Signaling and Ageing. In: Vlamos, P., Alexiou, A. (eds) GeNeDis 2014. Advances in Experimental Medicine and Biology, vol 822. Springer, Cham. https://doi.org/10.1007/978-3-319-08927-0_6

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