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Medication-Induced Seizures and Status Epilepticus

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Continuous EEG Monitoring

Abstract

Drug-induced seizures (DIS) were first described in the literature in the 1950s after the psychotropic drugs chlorpromazine and imipramine were observed to cause secondarily generalized tonic-clonic seizures [1]. In the mid-twentieth century, stimulants such as pentylenetetrazol and penicillin, which were described to have caused seizures in humans, were also used to create animal models for epilepsy research [2]. DIS are not considered to be epilepsy. The myriad of causes can be due to direct medication effect on brain receptors, withdrawal effects from antiepileptic medications and benzodiazepines, and medications causing electrolyte disturbances.

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Author information

Authors and Affiliations

  1. Department of Neurology, Wayne State University, 4201 St. Antoine, UHC-8A, Detroit, MI, 48201, USA

    Deepti Zutshi MD

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  1. Deepti Zutshi MD
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Correspondence to Deepti Zutshi MD .

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Editors and Affiliations

  1. Neurology, Duke University Medical Center Neurology, Durham, North Carolina, USA

    Aatif M. Husain

  2. Neurology, Duke University Medical Center, Durham, North Carolina, USA

    Saurabh R. Sinha

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Zutshi, D. (2017). Medication-Induced Seizures and Status Epilepticus. In: Husain, A., Sinha, S. (eds) Continuous EEG Monitoring. Springer, Cham. https://doi.org/10.1007/978-3-319-31230-9_22

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  • DOI: https://doi.org/10.1007/978-3-319-31230-9_22

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-31230-9

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