Abstract
Evidence shows links between stress at work and negative health outcomes. It is essential to prove that underlying psychobiological pathways substantiate the statistical associations reported in epidemiological studies. This chapter demonstrates how chronic work stress in terms of the Effort-Reward-Imbalance (ERI) model ‘gets under the skin’ (in the long run). It reviews the main findings from naturalistic and (quasi-) experimental studies, demonstrating effects of stressful work conditions on the autonomic nervous system, on the endocrine stress system (HPA and SAM axis), on the immune and blood coagulation system, and on cardiovascular responses. Innovative insights from this basic science research enrich the body of evidence on ‘hard’ endpoints, such as the clinically manifest diseases discussed in previous chapters. Thus, this chapter illustrates impressive advances of scientific knowledge resulting from trans-disciplinary research.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Almadi, T., Cathers, I., Hamdan Mansour, A. M., & Chow, C. M. (2012). The association between work stress and inflammatory biomarkers in Jordanian male workers. Psychophysiology, 49(2), 172–177. doi:10.1111/j.1469-8986.2011.01296.x.
Almadi, T., Cathers, I., & Chow, C. M. (2013). Associations among work-related stress, cortisol, inflammation, and metabolic syndrome. Psychophysiology, 50(9), 821–830. doi:10.1111/psyp.12069.
Angerer, P., Gündel, H., & Siegrist, K. (2014). Stress: Psychosocial work load and risks for cardiovascular disease and depression. Deutsche Medizinische Wochenschrift, 139(24), 1315–1319. doi:10.1055/s-0034-1370112.
Aust, B., Peter, R., & Siegrist, J. (1997). Stress management in bus drivers: A pilot study based on the model of effort-reward imbalance. International Journal of Stress Management, 4, 297–305. doi:10.1023/B:IJSM.0000008709.11196.19.
Backe, E. M., Seidler, A., Latza, U., Rossnagel, K., & Schumann, B. (2012). The role of psychosocial stress at work for the development of cardiovascular diseases: A systematic review. International Archives of Occupational and Environmental Health, 85(1), 67–79. doi:10.1007/s00420-011-0643-6.
Bathman, L. M., Almond, J., Hazi, A., & Wright, B. J. (2013). Effort-reward imbalance at work and pre-clinical biological indices of ill-health: The case for salivary immunoglobulin A. Brain, Behavior, and Immunity, 33, 74–79. doi:10.1016/j.bbi.2013.05.010.
Bellingrath, S., & Kudielka, B. M. (2008). Effort-reward-imbalance and overcommitment are associated with hypothalamus-pituitary-adrenal (HPA) axis responses to acute psychosocial stress in healthy working schoolteachers. Psychoneuroendocrinology, 33(10), 1335–1343. doi:10.1016/j.psyneuen.2008.07.008.
Bellingrath, S., Weigl, T., & Kudielka, B. M. (2008). Cortisol dysregulation in school teachers in relation to burnout, vital exhaustion, and effort-reward-imbalance. Biological Psychology, 78(1), 104–113. doi:10.1016/j.biopsycho.2008.01.006.
Bellingrath, S., Weigl, T., & Kudielka, B. M. (2009). Chronic work stress and exhaustion is associated with higher allostastic load in female school teachers. Stress, 12(1), 37–48. doi:10.1080/10253890802042041.
Bellingrath, S., Rohleder, N., & Kudielka, B. M. (2010). Healthy working school teachers with high effort-reward-imbalance and overcommitment show increased pro-inflammatory immune activity and a dampened innate immune defence. Brain, Behavior, and Immunity, 24(8), 1332–1339. doi:10.1016/j.bbi.2010.06.011.
Bellingrath, S., Rohleder, N., & Kudielka, B. M. (2013). Effort-reward-imbalance in healthy teachers is associated with higher LPS-stimulated production and lower glucocorticoid sensitivity of interleukin-6 in vitro. Biological Psychology, 92(2), 403–409. doi:10.1016/j.biopsycho.2012.12.003.
Berset, M., Semmer, N. K., Elfering, A., Jacobshagen, N., & Meier, L. L. (2011). Does stress at work make you gain weight? A two-year longitudinal study. Scandinavian Journal of Work, Environment and Health, 37(1), 45–53. doi:10.5271/sjweh.3089.
Bosch, J. A., Fischer, J. E., & Fishcher, J. C. (2009). Psychologically adverse work conditions are associated with CD8+T cell differentiation indicative of immunesenescence. Brain, Behavior, and Immunity, 23(4), 527–534. doi:10.1016/j.bbi.2009.02.002.
Bosma, H., Peter, R., Siegrist, J., & Marmot, M. (1998). Two alternative job stress models and the risk of coronary heart disease. American Journal of Public Health, 88(1), 68–74. doi:10.2105/AJPH.88.1.68.
Cannon, W. B. (1914). The interrelations of emotions as suggested by recent physiological researches. American Journal of Psychology, 25(2), 256–282. doi:10.2307/1413414.
Chandola, T., Heraclides, A., & Kumari, M. (2010). Psychophysiological biomarkers of workplace stressors. Neuroscience and Biobehavioral Reviews, 35(1), 51–57. doi:10.1016/j.neubiorev.2009.11.005.
Chrousos, G. P., & Gold, P. W. (1992). The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA, 267(9), 1244–1252. doi:10.1001/jama.267.9.1244.
Conner, T. S., & Barrett, L. F. (2012). Trends in ambulatory self-report: The role of momentary experience in psychosomatic medicine. Psychosomatic Medicine, 74(4), 327–337. doi:10.1097/PSY.0b013e3182546f18.
Cooper, C. (2008). Well-being – absenteeism, presenteeism, costs and challenges. Occupational Medicine, 58(8), 522–524. doi:10.1093/occmed/kqn124.
Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G. D., Pepys, M. B., & Gudnason, V. (2004). C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. New England Journal of Medicine, 350(14), 1387–1397. doi:10.1056/NEJMoa032804.
Dockray, S., Bhattacharyya, M. R., Molloy, G. J., & Steptoe, A. (2008). The cortisol awakening response in relation to objective and subjective measures of waking in the morning. Psychoneuroendocrinology, 33(1), 77–82. doi:10.1016/j.psyneuen.2007.10.001.
Eller, N. H., & Netterstrom, B. (2007). Psychosocial factors at home and at work and four-year progression in intima media thickness. International Journal of Behavioral Medicine, 14(1), 21–29. doi:10.1007/BF02999224.
Eller, N. H., Netterstrom, B., & Hansen, A. M. (2006). Psychosocial factors at home and at work and levels of salivary cortisol. Biological Psychology, 73(3), 280–287. doi:10.1016/j.biopsycho.2006.05.003.
Eller, N. H., Netterstrom, B., Gyntelberg, F., Kristensen, T. S., Nielsen, F., Steptoe, A., & Theorell, T. (2009). Work-related psychosocial factors and the development of ischemic heart disease: A systematic review. Cardiology in Review, 17(2), 83–97. doi:10.1097/CRD.0b013e318198c8e9.
Eller, N. H., Blond, M., Nielsen, M., Kristiansen, J., & Netterstrom, B. (2011a). Effort reward imbalance is associated with vagal withdrawal in Danish public sector employees. International Journal of Psychophysiology, 81(3), 218–224. doi:10.1016/j.ijpsycho.2011.06.014.
Eller, N. H., Kristiansen, J., & Hansen, A. M. (2011b). Long-term effects of psychosocial factors of home and work on biomarkers of stress. International Journal of Psychophysiology, 79(2), 195–202. doi:10.1016/j.ijpsycho.2010.10.009.
Eller, N. H., Nielsen, S. F., Blond, M., Nielsen, M. L., Hansen, A. M., & Netterstrom, B. (2012). Effort reward imbalance, and salivary cortisol in the morning. Biological Psychology, 89(2), 342–348. doi:10.1016/j.biopsycho.2011.11.007.
Falk. A., Menrath. I., Verde. P. E., & Siegrist, J. (2011). Cardiovascular consequences of unfair pay (IZA DP No. 5720, Discussion paper series). Institute for the Study of Labor.
Fischer, J. C., Kudielka, B. M., von Känel, R., Siegrist, J., Thayer, J. F., & Fischer, J. E. (2009). Bone-marrow derived progenitor cells are associated with psychosocial determinants of health after controlling for classical biological and behavioral cardiovascular risk factors. Brain, Behavior, and Immunity, 23(4), 419–426. doi:10.1016/j.bbi.2008.08.005.
Flook, L., Goldberg, S. B., Pinger, L., Bonus, K., & Davidson, R. J. (2013). Mindfulness for teachers: A pilot study to assess effects on stress, burnout and teaching efficacy. Mind Brain Education, 7(3), 182. doi:10.1111/mbe.12026.
Franke, W. D., Kohut, M. L., Russell, D. W., Yoo, H. L., Ekkekakis, P., & Ramey, S. P. (2010). Is job-related stress the link between cardiovascular disease and the law enforcement profession? Journal of Occupational and Environmental Medicine, 52(5), 561–565. doi:10.1097/JOM.0b013e3181dd086b.
Gaab, J., Blattler, N., Menzi, T., Pabst, B., Stoyer, S., & Ehlert, U. (2003). Randomized controlled evaluation of the effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects. Psychoneuroendocrinology, 28(6), 767–779. doi:10.1016/S0306-4530(02)00069-0.
Garza, J. L., Cavallari, J. M., Eijckelhof, B. H., Huysmans, M. A., Thamsuwan, O., Johnson, P. W., van der Beek, A. J., & Dennerlein, J. T. (2014). Office workers with high effort-reward imbalance and overcommitment have greater decreases in heart rate variability over a 2-h working period. International Archives of Occupational and Environmental Health. doi:10.1007/s00420-014-0983-0.
Gilbert-Ouimet, M., Brisson, C., Vezina, M., Milot, A., & Blanchette, C. (2012). Repeated exposure to effort-reward imbalance, increased blood pressure, and hypertension incidence among white-collar workers: Effort-reward imbalance and blood pressure. Journal of Psychosomatic Research, 72(1), 26–32. doi:10.1016/j.jpsychores.2011.07.002.
Gilbert-Ouimet, M., Trudel, X., Brisson, C., Milot, A., & Vezina, M. (2014). Adverse effects of psychosocial work factors on blood pressure: Systematic review of studies on demand-control-support and effort-reward imbalance models. Scandinavian Journal of Work, Environment and Health, 40(2), 109–132. doi:10.5271/sjweh.3390.
Glozier, N., Tofler, G. H., Colquhoun, D. M., Bunker, S. J., Clarke, D. M., Hare, D. L., Hickie, I. B., Tatoulis, J., Thompson, D. R., Wilson, A., & Branagan, M. G. (2013). Psychosocial risk factors for coronary heart disease. Medical Journal of Australia, 199(3), 179–180. doi:10.5694/mja13.10440.
Hamer, M., Williams, E., Vuonovirta, R., Giacobazzi, P., Gibson, E. L., & Steptoe, A. (2006). The effects of effort-reward imbalance on inflammatory and cardiovascular responses to mental stress. Psychosomatic Medicine, 68(3), 408–413. doi:10.1097/01.psy.0000221227.02975.a0.
Hammerfald, K., Eberle, C., Grau, M., Kinsperger, A., Zimmermann, A., Ehlert, U., & Gaab, J. (2006). Persistent effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects – a randomized controlled trial. Psychoneuroendocrinology, 31(3), 333–339. doi:10.1016/j.psyneuen.2005.08.007.
Hansen, A. M., Larsen, A. D., Rugulies, R., Garde, A. H., & Knudsen, L. E. (2009). A review of the effect of the psychosocial working environment on physiological changes in blood and urine. Basic and Clinical Pharmacology and Toxicology, 105(2), 73–83. doi:10.1111/j.1742-7843.2009.00444.x.
Hanson, E. K., Maas, C. J., Meijman, T. F., & Godaert, G. L. (2000). Cortisol secretion throughout the day, perceptions of the work environment, and negative affect. Annals of Behavioral Medicine, 22(4), 316–324. doi:10.1007/BF02895668.
Hanson, E. K., Godaert, G. L., Maas, C. J., & Meijman, T. F. (2001). Vagal cardiac control throughout the day: The relative importance of effort-reward imbalance and within-day measurements of mood, demand and satisfaction. Biological Psychology, 56(1), 23–44. doi:10.1016/S0301-0511(01)00066-7.
Harris, A., Ursin, H., Murison, R., & Eriksen, H. R. (2007). Coffee, stress and cortisol in nursing staff. Psychoneuroendocrinology, 32(4), 322–330. doi:10.1016/j.psyneuen.2007.01.003.
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25(1), 1–35. doi:10.1016/S0306-4530(99)00035-9.
Hellhammer, D. H., & Wade, S. (1993). Endocrine correlates of stress vulnerability. Psychotherapy and Psychosomatics, 60(1), 8–17. doi:10.1159/000288675.
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003). Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Frontiers in Neuroendocrinology, 24(3), 151–180. doi:10.1016/j.yfrne.2003.07.001.
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005). Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis. Progress in Neuropsychopharmacology and Biological Psychiatry, 29(8), 1201–1213. doi:10.1016/j.pnpbp.2005.08.006.
Hintsanen, M., Elovainio, M., Puttonen, S., Kivimäki, M., Koskinen, T., Raitakari, O. T., & Keltikangas-Järvinen, L. (2007). Effort-reward imbalance, heart rate, and heart rate variability: The cardiovascular risk in Young Finns Study. International Journal of Behavioral Medicine, 14(4), 202–212. doi:10.1007/BF03002994.
Hwang, W. J., & Lee, C. Y. (2014). Effect of psychosocial factors on metabolic syndrome in male and female blue-collar workers. Japan Journal of Nursing Science, 11(1), 23–34. doi:10.1111/j.1742-7924.2012.00226.x.
Inoue, A., Kawakami, N., Ishizaki, M., Tabata, M., Tsuchiya, M., Akiyama, M., Kitazume, A., Kuroda, M., & Shimazu, A. (2009). Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan. Journal of Psychosomatic Research, 66(4), 329–334. doi:10.1016/j.jpsychores.2008.09.016.
Irie, M., Tsutsumi, A., Shioji, I., & Kobayashi, F. (2004). Effort-reward imbalance and physical health among Japanese workers in a recently downsized corporation. International Archives of Occupational and Environmental Health, 77(6), 409–417. doi:10.1007/s00420-004-0533-2.
Jarczok, M. N., Jarczok, M., Mauss, D., Koenig, J., Li, J., Herr, R. M., & Thayer, J. F. (2013). Autonomic nervous system activity and workplace stressors – a systematic review. Neuroscience and Biobehavioral Reviews, 37(8), 1810–1823. doi:10.1016/j.neubiorev.2013.07.004.
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience and Biobehavioral Reviews, 35(1), 2–16. doi:10.1016/j.neubiorev.2009.10.002.
Karasek, R. A., & Theorell, T. (1992). Healthy work: Stress, productivity, and the reconstruction of working life. New York: Basic Books.
Karlson, B., Eek, F., Hansen, A. M., Garde, A. H., & Orbaek, P. (2011). Cortisol variability and self-reports in the measurement of work-related stress. Stress and Health, 27(2), E11–E24. doi:10.1002/smi.1330.
Kivimäki, M., Leino-Arjas, P., Luukkonen, R., Riihimäki, H., Vahtera, J., & Kirjonen, J. (2002). Work stress and risk of cardiovascular mortality: Prospective cohort study of industrial employees. British Medical Journal, 325(7369), 857–860. doi:10.1136/bmj.325.7369.857.
Kivimäki, M., Virtanen, M., Elovainio, M., Kouvonen, A., Vaananen, A., & Vahtera, J. (2006). Work stress in the etiology of coronary heart disease – a meta-analysis. Scandinavian Journal of Work, Environment and Health, 32(6), 431–442. doi:10.5271/sjweh.1049.
Kouvonen, A., Kivimäki, M., Cox, S. J., Cox, T., & Vahtera, J. (2005). Relationship between work stress and body mass index among 45,810 female and male employees. Psychosomatic Medicine, 67(4), 577–583. doi:10.1097/01.psy.0000170330.08704.62.
Kudielka, B. M., & Kirschbaum, C. (2007). Biological bases of the stress response. In M. Al Absi (Ed.), Stress and addiction: Biological and psychological mechanisms (Vol. 1, pp. 3–19). Amsterdam: Elsevier. chapter 1, section I: Neurobiology of Stress and Addiction.
Kudielka, B. M., Gierens, A., Hellhammer, D. H., Wüst, S., & Schlotz, W. (2012). Salivary cortisol in ambulatory assessment-some dos, some don‘ts, and some open questions. Psychosomatic Medicine, 74(4), 418–431. doi:10.1097/PSY.0b013e31825434c7.
Kumari, M., Head, J., & Marmot, M. (2004). Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study. Archives of Internal Medicine, 164(17), 1873–1880. doi:10.1001/archinte.164.17.1873.
Lazarus, R. S., & Folkman, S. (1984). Stress, appraisal, and coping. New York: Springer.
Li, J., Jarczok, M. N., Loerbroks, A., Schollgen, I., Siegrist, J., Bosch, J. A., Wilson, M. G., Mauss, D., & Fischer, J. E. (2013). Work stress is associated with diabetes and prediabetes: Cross-sectional results from the MIPH industrial cohort studies. International Journal of Behavioral Medicine, 20(4), 495–503. doi:10.1007/s12529-012-9255-0.
Liao, J., Brunner, E. J., & Kumari, M. (2013). Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study. PLoS One, 8(12), e81020. doi:10.1371/journal.pone.0081020.
Limm, H., Gündel, H., Heinmüller, M., Marten-Mittag, B., Nater, U. M., Siegrist, J., & Angerer, P. (2011). Stress management interventions in the workplace improve stress reactivity: A randomised controlled trial. Occupational and Environmental Medicine, 68(2), 126–133. doi:10.1136/oem.2009.054148.
Loerbroks, A., Schilling, O., Haxsen, V., Jarczok, M. N., Thayer, J. F., & Fischer, J. E. (2010). The fruits of ones labor: Effort-reward imbalance but not job strain is related to heart rate variability across the day in 35–44-year-old workers. Journal of Psychosomatic Research, 69(2), 151–159. doi:10.1016/j.jpsychores.2010.03.004.
Magnavita, N., & Fileni, A. (2014). Work stress and metabolic syndrome in radiologists: First evidence. Radiologia Medica, 119(2), 142–148. doi:10.1007/s11547-013-0329-0.
Maina, G., Bovenzi, M., Palmas, A., & Filon, F. L. (2009). Associations between two job stress models and measures of salivary cortisol. International Archives of Occupational and Environmental Health, 82(9), 1141–1150. doi:10.1007/s00420-009-0439-0.
Maina, G., Bovenzi, M., Palmas, A., Prodi, A., & Filon, F. L. (2011). Job strain, effort-reward imbalance and ambulatory blood pressure: Results of a cross-sectional study in call handler operators. International Archives of Occupational and Environmental Health, 84(4), 383–391. doi:10.1007/s00420-010-0576-5.
Malliani, A., Pagani, M., & Lombardi, F. (1994). Physiology and clinical implications of variability of cardiovascular parameters with focus on heart rate and blood pressure. American Journal of Cardiology, 73(10), 3C–9C. doi:10.1016/0002-9149(94)90617-3.
Marchand, A., Juster, R. P., Durand, P., & Lupien, S. J. (2015). Work stress models and diurnal cortisol variations: The SALVEO study. Journal of Occupational Health Psychology. doi:10.1037/a0039674.
Mason, J. W. (1975) A historical view of the stress field. Journal of Human Stress, 1(1), 6–12. contd. doi:10.1080/0097840X.1975.9940399.
Mauss, D., Li, J., Schmidt, B., Angerer, P., & Jarczok, M. N. (2015). Measuring allostatic load in the workforce: A systematic review. Industrial Health, 53(1), 5–20. doi:10.2486/indhealth.2014-0122.
McEwen, B. S. (1998a). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338(3), 171–179.
McEwen, B. S. (1998b). Stress, adaptation, and disease. Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33–44. doi:10.1111/j.1749-6632.1998.tb09546.x.
McEwen, B. S. (2003). Interacting mediators of allostasis and allostatic load: Towards an understanding of resilience in aging. Metabolism, 52(10 Suppl 2), 10–16. doi:10.1016/S0026-0495(03)00295-6.
McEwen, B. S. (2006). Protective and damaging effects of stress mediators: Central role of the brain. Dialogues in Clinical Neuroscience, 8(4), 367–381. doi:10.1016/S0079-6123(08)62128-7.
McEwen, B. S. (2007). Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiological Reviews, 87(3), 873–904. doi:10.1152/physrev.00041.2006.
McEwen, B. S., & Seeman, T. (1999). Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load. Annals of the New York Academy of Sciences, 896, 30–47. doi:10.1111/j.1749-6632.1999.tb08103.x.
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005). Clinical depression and regulation of the inflammatory response during acute stress. Psychosomatic Medicine, 67(5), 679–687. doi:10.1097/01.psy.0000174172.82428.ce.
Nakata, A., Takahashi, M., & Irie, M. (2011). Effort-reward imbalance, overcommitment, and cellular immune measures among white-collar employees. Biological Psychology, 88(2-3), 270–279. doi:10.1016/j.biopsycho.2011.08.012.
Ostry, A. S., Radi, S., Louie, A. M., & LaMontagne, A. D. (2006). Psychosocial and other working conditions in relation to body mass index in a representative sample of Australian workers. BMC Public Health, 6, 53. doi:10.1186/1471-2458-6-53.
Ota, A., Mase, J., Howteerakul, N., Rajatanun, T., Suwannapong, N., Yatsuya, H., & Ono, Y. (2014). The effort-reward imbalance work-stress model and daytime salivary cortisol and dehydroepiandrosterone (DHEA) among Japanese women. Science Reports, 4, 6402. doi:10.1038/srep06402.
Peter, R., & Siegrist, J. (1997). Chronic work stress, sickness absence, and hypertension in middle managers: General or specific sociological explanations? Social Science & Medicine, 45(7), 1111–1120. doi:10.1016/S0277-9536(97)00039-7.
Peter, R., Alfredsson, L., Hammar, N., Siegrist, J., Theorell, T., & Westerholm, P. (1998a). High effort, low reward, and cardiovascular risk factors in employed Swedish men and women: Baseline results from the WOLF study. Journal of Epidemiology and Community Health, 52(9), 540–547. doi:10.1136/jech.52.9.540.
Peter, R., Geissler, H., & Siegrist, J. (1998b). Associations of effort-reward imbalance at work and reported symptoms in different groups of male and female public transport workers. Stress Medicine, 14(3), 175–182. doi:10.1002/(Sici)1099-1700(199807)14:3<175::Aid-Smi775>3.0.Co;2-4.
Porges, S. W. (1992). Vagal tone: A physiologic marker of stress vulnerability. Pediatrics, 90(3 Pt 2), 498–504.
Pruessner, J. C., Wolf, O. T., Hellhammer, D. H., Buske-Kirschbaum, A., von Auer, K., Jobst, S., Kaspers, F., & Kirschbaum, C. (1997). Free cortisol levels after awakening: A reliable biological marker for the assessment of adrenocortical activity. Life Sciences, 61(26), 2539–2549. doi:10.1016/S0024-3205(97)01008-4.
Qi, X., Zhang, J., Liu, Y., Ji, S., Chen, Z., Sluiter, J. K., & Deng, H. (2014). Relationship between effort-reward imbalance and hair cortisol concentration in female kindergarten teachers. Journal of Psychosomatic Research, 76(4), 329–332. doi:10.1016/j.jpsychores.2014.01.008.
Rugulies, R., Aust, B., Siegrist, J., von dem Knesebeck, O., Bultmann, U., Bjorner, J. B., & Burr, H. (2009). Distribution of effort-reward imbalance in Denmark and its prospective association with a decline in self-rated health. Journal of Occupational and Environmental Medicine, 51(8), 870–878. doi:10.1097/JOM.0b013e3181a9086c.
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000). How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Reviews, 21(1), 55–89. doi:10.1210/edrv.21.1.0389.
Schmidt, B., Bosch, J. A., Jarczok, M. N., Herr, R. M., Loerbroks, A., van Vianen, A. E. M., & Fischer, J. E. (2015). Effort-reward imbalance is associated with the metabolic syndrome – findings from the Mannheim Industrial Cohort Study (MICS). International Journal of Cardiology, 178, 24–28. doi:10.1016/j.ijcard.2014.10.115.
Seeman, T. E., & Robbins, R. J. (1994). Aging and hypothalamic-pituitary-adrenal response to challenge in humans. Endocrine Reviews, 15(2), 233–260. doi:10.1210/er.15.2.233.
Selye, H. (1950). Stress: The physiology and pathology of exposure to stress. Montreal: Acta Medica.
Siegrist, J. (2002). Reducing social inequalities in health: Work-related strategies. Scandinavian Journal Public Health, 30(3), 49–53. doi:10.1177/14034948020300032501.
Siegrist, J. (2005). Social reciprocity and health: New scientific evidence and policy implications. Psychoneuroendocrinology, 30(10), 1033–1038. doi:10.1016/j.psyneuen.2005.03.017.
Siegrist, J. (2010). Effort-reward imbalance at work and cardiovascular diseases. International Journal of Occupational Medicine and Environmental Health, 23(3), 279–285. doi:10.2478/v10001-010-0013-8.
Siegrist, J. (2013). Effort-reward imbalance at work and depression: Current research evidence. Nervenarzt, 84(1), 33–37. doi:10.1007/s00115-012-3667-6.
Siegrist, J., & Peter, R. (1996). Threat to occupational status control and cardiovascular risk. Israel Journal Medical Science, 32(3–4), 179–184.
Siegrist, J., & Rödel, A. (2006). Work stress and health risk behavior. Scandinavian Journal of Work, Environment and Health, 32(6), 473–481. doi:10.5271/sjweh.1052.
Siegrist, J., Klein, D., & Voigt, K. H. (1997). Linking sociological with physiological data: The model of effort-reward imbalance at work. Acta Physiologica Scandinavica. Supplementum, 640, 112–116.
Söderberg, M., Rosengren, A., Hillström, J., Lissner, L., & Toren, K. (2012). A cross-sectional study of the relationship between job demand-control, effort-reward imbalance and cardiovascular heart disease risk factors. BMC Public Health, 12, 1102. doi:10.1186/1471-2458-12-1102.
Souza, G. G., Mendonca-de-Souza, A. C., Barros, E. M., Coutinho, E. F., Oliveira, L., Mendlowicz, M. V., Figueira, I., & Volchan, E. (2007). Resilience and vagal tone predict cardiac recovery from acute social stress. Stress, 10(4), 368–374. doi:10.1080/10253890701419886.
Stalder, T., Kirschbaum, C., Kudielka, B. M., Adam, E. K., Pruessner, J. C., Wüst, S., Dockray, S., Smyth, N., Evans, P., Hellhammer, D. H., Miller, R., Wetherell, M. A., Lupien, S., & Clow, A. (2016). Assessment of the cortisol awakening response: Expert consensus guidelines. Psychoneuroendocrinology. doi:10.1016/j.psyneuen.2015.10.010.
Steptoe, A., Siegrist, J., Kirschbaum, C., & Marmot, M. (2004). Effort-reward imbalance, overcommitment, and measures of cortisol and blood pressure over the working day. Psychosomatic Medicine, 66(3), 323–329. doi:10.1097/00006842-200405000-00006.
Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. Handbook of life stress, cognition and health. New York: John Wiley & Sons.
Storch, M., Gaab, J., Kuttel, Y., Stussi, A. C., & Fend, H. (2007). Psychoneuroendocrine effects of resource-activating stress management training. Health Psychology, 26(4), 456–463. doi:10.1037/0278-6133.26.4.456.
Takaki, J. (2013). Associations of job stress indicators with oxidative biomarkers in Japanese men and women. International Journal of Environmental Research and Public Health, 10(12), 6662–6671. doi:10.3390/ijerph10126662.
Takaki, J., Minoura, A., Irimajiri, H., Hayama, A., Hibino, Y., Kanbara, S., Sakano, N., & Ogino, K. (2010). Interactive effects of job stress and body mass index on over-eating. Journal of Occupational Health, 52(1), 66–73. doi:10.1539/joh.M9006.
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability – standards of measurement, physiological interpretation, and clinical use. European Heart Journal, 17, 354–381.
Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F. (2010). The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. International Journal of Cardiology, 141(2), 122–131. doi:10.1016/j.ijcard.2009.09.543.
Thayer, J. F., Ahs, F., Fredrikson, M., Sollers, J. J., 3rd, & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: Implications for heart rate variability as a marker of stress and health. Neuroscience and Biobehavioral Reviews, 36(2), 747–756. doi:10.1016/j.neubiorev.2011.11.009.
Tsigos, C., & Chrousos, G. P. (2002). Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. Journal of Psychosomatic Research, 53(4), 865–871. doi:10.1016/S0022-3999(02)00429-4.
Tsutsumi, A., & Kawakami, N. (2004). A review of empirical studies on the model of effort-reward imbalance at work: Reducing occupational stress by implementing a new theory. Social Science & Medicine, 59(11), 2335–2359. doi:10.1016/j.socscimed.2004.03.030.
Ursin, H., & Eriksen, H. R. (2004). The cognitive activation theory of stress. Psychoneuroendocrinology, 29(5), 567–592. doi:10.1016/S0306-4530(03)00091-X.
Uusitalo, A., Mets, T., Martinmaki, K., Mauno, S., Kinnunen, U., & Rusko, H. (2011). Heart rate variability related to effort at work. Applied Ergonomics, 42(6), 830–838. doi:10.1016/j.apergo.2011.01.005.
van Vegchel, N., de Jonge, J., Bosma, H., & Schaufeli, W. (2005). Reviewing the effort-reward imbalance model: Drawing up the balance of 45 empirical studies. Social Science & Medicine, 60(5), 1117–1131. doi:10.1016/j.socscimed.2004.06.043.
Virtanen, M., Oksanen, T., Kawachi, I., Subramanian, S. V., Elovainio, M., Suominen, S., Linna, A., Koponen, A., Pentti, J., Kivimäki, M., & Vahtera, J. (2012). Organizational justice in primary-care health centers and glycemic control in patients with type 2 diabetes. Medical Care, 50(10), 831–835. doi:10.1097/MLR.0b013e31825dd741.
von Känel, R., Bellingrath, S., & Kudielka, B. M. (2009). Overcommitment but not effort-reward imbalance relates to stress-induced coagulation changes in teachers. Annals of Behavioral Medicine, 37(1), 20–28. doi:10.1007/s12160-009-9082-y.
Vrijkotte, T. G. M., van Doornen, L. J. P., & de Geus, E. J. C. (1999). Work stress and metabolic and hemostatic risk factors. Psychosomatic Medicine, 61(6), 796–805. doi:10.1097/00006842-199911000-00012.
Vrijkotte, T. G., van Doornen, L. J., & de Geus, E. J. (2000). Effects of work stress on ambulatory blood pressure, heart rate, and heart rate variability. Hypertension, 35(4), 880–886. doi:10.1161/01.HYP.35.4.880.
Wilhelm, I., Born, J., Kudielka, B. M., Schlotz, W., & Wüst, S. (2007). Is the cortisol awakening rise a response to awakening? Psychoneuroendocrinology, 32(4), 358–366. doi:10.1016/j.psyneuen.2007.01.008.
Wirtz, P. H., Siegrist, J., Rimmele, U., & Ehlert, U. (2008). Higher overcommitment to work is associated with lower norepinephrine secretion before and after acute psychosocial stress in men. Psychoneuroendocrinology, 33(1), 92–99. doi:10.1016/j.psyneuen.2007.10.003.
Wirtz, P. H., Siegrist, J., Schuhmacher, A., Hoefels, S., Maier, W., & Zobel, A. W. (2010). Higher overcommitment to work is associated with higher plasma cortisol but not ACTH responses in the combined dexamethasone/CRH test in apparently healthy men and women. Psychoneuroendocrinology, 35(4), 536–543. doi:10.1016/j.psyneuen.2009.09.002.
Wolfram, M., Bellingrath, S., Feuerhahn, N., & Kudielka, B. M. (2013). Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus-pituitary-adrenal (HPA) axis responses to a low-dose ACTH1-24 (Synacthen) and dexamethasone-CRH test in healthy school teachers. Stress, 16(1), 54–64. doi:10.3109/10253890.2012.683465.
Wright, B. J. (2011). Effort-reward imbalance is associated with salivary immunoglobulin a and cortisol secretion in disability workers. Journal of Occupational and Environmental Medicine, 53(3), 308–312. doi:10.1097/JOM.0b013e31820c90b7.
Wüst, S., Wolf, J., Hellhammer, D. H., Federenko, I., Schommer, N., & Kirschbaum, C. (2000). The cortisol awakening response – normal values and confounds. Noise & Health, 2(7), 79–88.
Wüst, S., Federenko, I. S., van Rossum, E. F., Koper, J. W., & Hellhammer, D. H. (2005). Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors. Psychoneuroendocrinology, 30(2), 199–211. doi:10.1016/j.psyneuen.2004.07.002.
Xu, L., Siegrist, J., Cao, W., Li, L., Tomlinson, B., & Chan, J. (2004). Measuring job stress and family stress in Chinese working women: A validation study focusing on blood pressure and psychosomatic symptoms. Women and Health, 39(2), 31–46. doi:10.1300/J013v39n02_03.
Xu, W., Hang, J., Cao, T., Shi, R., Zeng, W., Deng, Y., Gao, W., Zhao, Y., & Guo, L. (2010). Job stress and carotid intima-media thickness in Chinese workers. Journal of Occupational Health, 52(5), 257–262.
Xu, W., Hang, J., Gao, W., Zhao, Y., Cao, T., & Guo, L. (2011). Association between job stress and newly detected combined dyslipidemia among Chinese workers: Findings from the SHISO study. Journal of Occupational Health, 53(5), 334–342.
Xu, W. X., Hang, J., Guo, L. J., Zhao, Y. M., Li, Z. P., & Gao, W. (2012). Plasma fibrinogen: A possible link between job stress and cardiovascular disease among Chinese workers. American Journal of Industrial Medicine, 55(2), 167–175. doi:10.1002/ajim.21017.
Xu, W. X., Chen, B. X., Guo, L. J., Li, Z. P., Zhao, Y. M., & Zeng, H. (2015). High-sensitivity CRP: Possible link between job stress and atherosclerosis. American Journal of Industrial Medicine, 58(7), 773–779. doi:10.1002/ajim.22470.
Yu, S. F., Zhou, W. H., Jiang, K. Y., Gu, G. Z., & Wang, S. (2008). Job stress, gene polymorphism of beta(2)-AR, and prevalence of hypertension. Biomedical and Environmental Sciences, 21(3), 239–246. doi:10.1016/S0895-3988(08)60036-7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Bellingrath, S., Kudielka, B.M. (2016). Psychobiological Pathways from Work Stress to Reduced Health: Naturalistic and Experimental Studies on the ERI Model. In: Siegrist, J., Wahrendorf, M. (eds) Work Stress and Health in a Globalized Economy. Aligning Perspectives on Health, Safety and Well-Being. Springer, Cham. https://doi.org/10.1007/978-3-319-32937-6_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-32937-6_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-32935-2
Online ISBN: 978-3-319-32937-6
eBook Packages: Behavioral Science and PsychologyBehavioral Science and Psychology (R0)