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Neuropathic Pruritus Secondary to Brain and Spinal Cord Tumors

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Pruritus

Abstract

Neuropathic itch refers to pruritus caused by neuronal or glial damage. Neuropathic itch has numerous causes and can arise from a local nerve fiber compression, or localized or generalized nerve fiber degeneration affecting different neuronal structures in the peripheral or central nervous system. Although rather rarely, brain and spinal cord tumors can be responsible for neuropathic itch, that can be the symptom allowing their diagnosis. Main involved tumors are ependymomas, hemangiomas, giomas and astrocytomas. Differential diagnoses are strokes and demyelinating disorders.

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References

  1. Misery L, Brenaut E, Le Garrec R, Abasq C, Genestet S, Marcorelles P, Zagnoli F. Neuropathic pruritus. Nat Rev Neurol. 2014;10:408–16.

    Article  PubMed  Google Scholar 

  2. Stumpf A, Ständer S. Neuropathic itch: diagnosis and management. Dermatol Ther. 2013;26:104–9.

    Article  PubMed  Google Scholar 

  3. Andreev VC, Petkov I. Skin manifestations associated with tumors of the brain. Br J Dermatol. 1975;92:675–8.

    Article  Google Scholar 

  4. Oaklander AL. Common neuropathic itch syndromes. Acta Derm Venereol. 2012;92:118–25.

    Article  PubMed  Google Scholar 

  5. Benesch M, Frappaz D, Massimino M. Spinal cord ependymomas in children and adolescents. Childs Nerv Syst. 2012;28:2017–28.

    Article  PubMed  Google Scholar 

  6. Kavak A, Dosoglu M. Can a spinal cord tumor cause brachioradial pruritus? J Am Acad Dermatol. 2002;46(3):437–40.

    Article  PubMed  Google Scholar 

  7. Fleuret C, Misery L. Prurit brachio-radial révélant un épendymome. Ann Dermatol Venereol. 2009;136:435–7.

    Article  CAS  PubMed  Google Scholar 

  8. Brenaut E, Nizery-Guermeur C, Audebert-Bellanger S, Ferkal S, Wolkenstien P, Misery L, Abasq-Thomas C. Clinical characteristics of pruritus in neurofibromatosis. Acta Derm Venereol. 2016;96:398–9.

    Google Scholar 

  9. Khosrotehrani K, Bastuji-Garin S, Riccardi VM, Birch P, Friedman JM, Wolkenstein P. Subcutaneous neurofibromas are associated with mortality in neurofibromatosis 1: a cohort study of 703 patients. Am J Med Genet. 2005;132A:49–53.

    Article  PubMed  Google Scholar 

  10. O’Brien DE, Brenner DS, Gutmann DH, Gereau RW. Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. J Pain. 2013;14:628–37.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Johnson RE, Kanigsberg ND, Jimenez CL. Localized pruritus: a presenting symptom of a spinal cord tumor in a child with features of neurofibromatosis. J Am Acad Dermatol. 2000;43:958–61.

    Article  CAS  PubMed  Google Scholar 

  12. Darken RS, Bogitch R, Leonard J, Perry A, McKinstry RC, Gutmann DH, et al. Brainstem glioma presenting as pruritus in children with neurofibromatosis-1. J Pediatr Hematol Oncol. 2009;31:972–6.

    Article  PubMed  Google Scholar 

  13. Summers CG, MacDonald JT. Paroxysmal facial itch: a presenting sign of childhood brainstem glioma. J Child Neurol. 1988;3:189–92.

    Article  CAS  PubMed  Google Scholar 

  14. Dey DD, Landrum O, Oaklander AL. Central neuropathic itch from spinal-cord cavernous hemangioma: a human case, a possible animal model, and hypotheses about pathogenesis. Pain. 2005;113:233–7.

    Article  PubMed  Google Scholar 

  15. Vandertop WP. Syringomyelia. Neuropediatrics. 2014;45:3–9.

    PubMed  Google Scholar 

  16. Kinsella LJ, Carney-Godley K, Feldmann E. Lichen simplex chronicus as the initial manifestation of intramedullary neoplasm and syringomyelia. Neurosurgery. 1992;30:418–21.

    Article  CAS  PubMed  Google Scholar 

  17. Sullivan MJ, Drake Jr ME. Unilateral pruritus and Nocardia brain abscess. Neurology. 1984;34:828–9.

    Article  CAS  PubMed  Google Scholar 

  18. West TW. Transverse myelitis – a review of the presentation, diagnosis and initial management. Discov Med. 2013;16:167–77.

    PubMed  Google Scholar 

  19. Iyer A, Rathnasabapathi D, Elsone L, Mutch K, Terlizzo M, Footitt D, Jacob A. Transverse myelitis associated with an itchy rash and hyperckemia: neuromyelitis optica associated with dermatitis herpetiformis. JAMA Neurol. 2014;71:630–3.

    Article  PubMed  Google Scholar 

  20. Bond LD, Keough GC. Neurogenic pruritus: a case of pruritus induced by transverse myelitis. Br J Dermatol. 2003;149:204–5.

    Article  PubMed  Google Scholar 

  21. Thielen AM, Vokatch N, Borradori L. Chronic hemicorporal prurigo related to a post-traumatic Brown-Séquard syndrome. Dermatology. 2008;217:45–7.

    Article  PubMed  Google Scholar 

  22. Dhand A, Aminoff MJ. The neurology of itch. Brain. 2014;137:313–22.

    Article  PubMed  Google Scholar 

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Correspondence to Laurent Misery MD, PhD .

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Misery, L. (2016). Neuropathic Pruritus Secondary to Brain and Spinal Cord Tumors. In: Misery, L., Ständer, S. (eds) Pruritus. Springer, Cham. https://doi.org/10.1007/978-3-319-33142-3_28

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  • DOI: https://doi.org/10.1007/978-3-319-33142-3_28

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33140-9

  • Online ISBN: 978-3-319-33142-3

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