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Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications

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Oxygen Transport to Tissue XXXVIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 923))

Abstract

The first systematic multi-center study of the clinical use of EPR oximetry has begun, with funding as a PPG from the NCI. Using particulate oxygen sensitive EPR, materials in three complementary forms (India Ink, “OxyChips”, and implantable resonators) the clinical value of the technique will be evaluated. The aims include using repeated measurement of tumor pO2 to monitor the effects of treatments on tumor pO2, to use the measurements to select suitable subjects for the type of treatment including the use of hyperoxic techniques, and to provide data that will enable existing clinical techniques which provide data relevant to tumor pO2 but which cannot directly measure it to be enhanced by determining circumstances where they can give dependable information about tumor pO2.

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Acknowledgments

This work was supported by grants from the National Institutes of Health [P01 CA190193 (the Dartmouth PPG) and R01 EB004031] and pilot project funding from the Prouty Fund of the Norris Cotton Cancer Center at Geisel Medical School.

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Authors and Affiliations

  1. Department of Radiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA

    Harold M. Swartz, Benjamin B. Williams, Huagang Hou, Nadeem Khan, Periannan Kuppusamy & Ann B. Flood

  2. Department of Medicine, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA

    Harold M. Swartz, Benjamin B. Williams, Lesley A. Jarvis, Philip E. Schaner & Periannan Kuppusamy

  3. Department of Surgery, Geisel School of Medicine at Dartmouth, One Medical Center Drive Lebanon, Lebanon, NH, USA

    Eunice Y. Chen

  4. Department of Radiation Oncology, Emory Medical School, Atlanta, GA, USA

    Arif Ali

  5. Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium

    Bernard Gallez

Authors
  1. Harold M. Swartz
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  2. Benjamin B. Williams
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  3. Huagang Hou
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  4. Nadeem Khan
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  5. Lesley A. Jarvis
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  6. Eunice Y. Chen
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  7. Philip E. Schaner
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  8. Arif Ali
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  9. Bernard Gallez
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  10. Periannan Kuppusamy
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  11. Ann B. Flood
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Corresponding author

Correspondence to Harold M. Swartz .

Editor information

Editors and Affiliations

  1. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Qingming Luo

  2. Molecular Imaging Laboratory, Department of Radiology, Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Lin Z. Li

  3. Microvascular Measurements, St. Lorenzen, Italy

    David K. Harrison

  4. Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China

    Hua Shi

  5. ISOTT Historian, Ellicott City, Maryland, USA

    Duane F. Bruley

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© 2016 Springer International Publishing Switzerland

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Swartz, H.M. et al. (2016). Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications. In: Luo, Q., Li, L., Harrison, D., Shi, H., Bruley, D. (eds) Oxygen Transport to Tissue XXXVIII. Advances in Experimental Medicine and Biology, vol 923. Springer, Cham. https://doi.org/10.1007/978-3-319-38810-6_13

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