Skip to main content
SpringerLink
Log in

Epidemiology of HPV-Positive Tumors in Europe and in the World

  • Chapter
  • First Online:
HPV Infection in Head and Neck Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 206))

Abstract

Strong evidence has accumulated in the last 15 years showing that infection by certain human papillomaviruses (HPVs) is etiologically involved in a subset of head and neck cancers (HNCs). In this chapter, epidemiologic-related topics on HNCs are reviewed: (i) HPV-attributable fractions and HPV-type distributions by different anatomical HNC sites, using not only HPV DNA but other more specific markers of causality; (ii) an update of the HPV-related HNCs burden worldwide and by regions; and finally, (iii) the determinants for HPV positivity in HNCs, focussing on gender, age, smoking habits, sexual behavior, and other related factors such as tonsillectomy performance. This information is essential in order to understand the burden of the disease and its dynamics and changing patterns, as well as for planning and assessment of the potential impact of HPV-based preventive strategies for HNCs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • A review of human carcinogens (2009) Part B: Biological agents/ IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, France: International Agency for Research on Cancer Monographs

    Google Scholar 

  • Castellsagué X, Alemany L, Quer M et al (2016) HPV involvement in head and neck cancers: comprehensive assessment of biomarkers in 3680 patients. J Natl Cancer Inst 108(6):djv403

    Google Scholar 

  • Chaturvedi AK, Engels EA, Pfeiffer RM et al (2011) Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 29:4294–4301

    Article  PubMed  PubMed Central  Google Scholar 

  • Chaturvedi AK, Anderson WF, Lortet-Tieulent J et al (2013) Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol 31:4550–4559

    Article  PubMed  PubMed Central  Google Scholar 

  • Combes JD, Chen AA, Franceschi S (2014) Prevalence of human papillomavirus in cancer of the oropharynx by gender. Cancer Epidemiol Biomarkers Prev 23(12):2954–2958

    Article  PubMed  Google Scholar 

  • De Martel C, Ferlay J, Franceschi S et al (2012) The global burden of cancers attributable to infections in the year 2008: a review and synthetic analysis. Lancet Oncol 13:607–615

    Article  PubMed  Google Scholar 

  • de Sanjosé S, Quint WG, Alemany L et al (2010) Retrospective International Survey and HPV Time Trends Study Group. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol 11(11):1048–1056

    Article  PubMed  Google Scholar 

  • D’Souza G, Wentz A, Kluz N et al (2016) Gender differences in risk factors and natural history of oral human papillomavirus (HPV) infection. J Infect Dis 10(pii):jiw063

    Google Scholar 

  • Fakhry C, Andersen KK, Christensen J et al (2015) The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry. Cancer Prev Res (Phila) 8(7):583–589

    Article  Google Scholar 

  • Ferlay J, Soerjomataram I, Ervik M et al (2013) GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11. Lyon, France: International Agency for Research on Cancer. http://globocan.iarc.fr. Accessed 09 Mar 2016

  • Forman D, de Martel C, Lacey CJ et al (2012) Global burden of human papillomavirus and related diseases. Vaccine 30(Suppl 5):F12–F23

    Article  PubMed  Google Scholar 

  • Gillison ML, D’Souza G, Westra W et al (2008) Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100(6):407–420

    Article  PubMed  Google Scholar 

  • Gillison ML, Alemany L, Snijders PJ et al (2012) Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis. Vaccine. 30(Suppl 5):F34–F54

    Article  PubMed  Google Scholar 

  • Gillison ML, Chaturvedi AK, Anderson WF et al (2015) Epidemiology of Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma. J Clin Oncol 33(29):3235–3242

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heck JE, Berthiller J, Vaccarella S et al (2010) Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol 39(1):166–181

    Article  PubMed  Google Scholar 

  • Herrero R, Castellsagué X, Pawlita M et al (2003) IARC Multicenter Oral Cancer Study Group. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 95(23):1772–1783

    Article  PubMed  Google Scholar 

  • Holzinger D, Schmitt M, Dyckhoff G et al (2012) Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement. Cancer Res 72(19):4993–5003

    Article  CAS  PubMed  Google Scholar 

  • IARC (1988) Monographs on the evaluation of carcinogenic risks to humans, vol. 44. Alcohol drinking. Lyon, France: International Agency for Research on Cancer Monographs

    Google Scholar 

  • IARC (2004) Monographs on the evaluation of carcinogenic risks to humans, vol. 83. Tobacco Smoke and Involuntary Smoking. Lyon, France: International Agency for Research on Cancer Monographs

    Google Scholar 

  • Jordan RC, Lingen MW, Perez-Ordonez B et al (2012) Validation of methods for oropharyngeal cancer HPV status determination in US cooperative group trials. Am J Surg Pathol 36(7):945–954

    Article  PubMed  Google Scholar 

  • Koshy E, Bottle A, Murray J et al (2014) Changing indications and socio-demographic determinants of (adeno)tonsillectomy among children in England–are they linked? A retrospective analysis of hospital data. PLoS ONE 9(8):e103600

    Article  PubMed  PubMed Central  Google Scholar 

  • Lingen MW, Xiao W, Schmitt A et al (2013) Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas. Oral Oncol 49(1):1–8

    Article  PubMed  Google Scholar 

  • Mehanna H, Beech T, Nicholson T et al (2013) The prevalence of human papillomavirus in oropharyngeal and non-oropharyngeal head and neck cancer—a systematic review and metaanalysis of trends by time and region. Head Neck 35:747–755

    Article  PubMed  Google Scholar 

  • Ndiaye C, Mena M, Alemany L et al (2014) HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 15(12):1319–1331

    Article  CAS  PubMed  Google Scholar 

  • Ng M, Freeman MK, Fleming TD et al (2014) Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA 311(2):183–192

    Article  CAS  PubMed  Google Scholar 

  • Walboomers JM, Jacobs MV, Manos MM et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189(1):12–19

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut Catala d’Oncologia (ICO) L’Hospitalet de Llobregat, Catalonia, Spain

    Xavier Castellsagué, Marisa Mena & Laia Alemany

Authors
  1. Xavier Castellsagué
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marisa Mena
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laia Alemany
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xavier Castellsagué .

Editor information

Editors and Affiliations

  1. Department of Head and Neck Surgery, Poznan University of Medical Sciences, The Greater Poland Cancer Centre, Poznań, Poland

    Wojciech Golusiński

  2. Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center/Cancer Center Amsterdam, Amsterdam, The Netherlands

    C. René Leemans

  3. Dept. of Head Medicine and Oral Health, University of Leipzig Clinic of Otolaryngology, Leipzig, Germany

    Andreas Dietz

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Castellsagué, X., Mena, M., Alemany, L. (2017). Epidemiology of HPV-Positive Tumors in Europe and in the World. In: Golusiński, W., Leemans, C., Dietz, A. (eds) HPV Infection in Head and Neck Cancer. Recent Results in Cancer Research, vol 206. Springer, Cham. https://doi.org/10.1007/978-3-319-43580-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-43580-0_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43578-7

  • Online ISBN: 978-3-319-43580-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation