Abstract
Reliable assessment of collateral blood supply is important in acute ischemic stroke. We propose a quantitative method for evaluation of collateral status on CT angiography (CTA). We collected CTA images of 70 patients from MR CLEAN with an occlusion in the M1 branch. Our proposed quantitative collateral score (qCS) consisted of atlas-based territory-at-risk identification and vessel segmentation using a Hessian-based filter. Ground truth was obtained by manual collateral scoring (mCS). Accuracy was evaluated by analysis of Spearman ρ and one-way ANOVA. Correlation of mCS and qCS with tissue death and functional outcome was assessed. Receiver operating characteristics curves of mCS and qCS were analyzed to distinguish favorable from unfavorable outcome. qCS strongly correlated with mCS and showed reliable correlations with tissue death and functional outcome. qCS showed higher discriminative power between favorable and unfavorable compared to mCS, indicating potential clinical value.
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Funding
Anna MM Boers and Ivo GH Jansen are supported by a grant from the Stichting Toegepast Wetenschappelijk Instituut voor Neuromodulatie (TWIN). The MR CLEAN trial was funded by the Dutch Heart Foundation and through unrestricted grants from AngioCare BV, Covidien/EV3, MEDAC Gmbh/LAMEPRO and Penumbra Inc.
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Boers, A.M.M. et al. (2017). Quantitative Collateral Grading on CT Angiography in Patients with Acute Ischemic Stroke. In: Cardoso, M., et al. Molecular Imaging, Reconstruction and Analysis of Moving Body Organs, and Stroke Imaging and Treatment. RAMBO CMMI SWITCH 2017 2017 2017. Lecture Notes in Computer Science(), vol 10555. Springer, Cham. https://doi.org/10.1007/978-3-319-67564-0_18
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DOI: https://doi.org/10.1007/978-3-319-67564-0_18
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