Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- ARMD:
-
Age-related macular degeneration
- BFE:
-
Blue Field Entoptoscope
- BP:
-
Blood pressure
- BPdiast:
-
Diastolic blood pressure
- BPmean:
-
Mean systemic blood pressure
- BPsyst:
-
Systolic blood pressure
- ChBF:
-
Choroidal blood flow
- CO2 :
-
Carbon dioxide
- CP:
-
Chromatic pulse
- CPT:
-
Cold pressor test
- CRA:
-
Central retinal artery
- CRV:
-
Central retinal vein
- D:
-
Diameter
- FAZ:
-
Foveal avascular zone
- fERG:
-
Flash electroretinogram
- FPA:
-
Fundus pulsation amplitude
- HR:
-
Heart rate
- IOP:
-
Intraocular pressure
- ISCEV:
-
International Society for Clinical Electrophysiology of Vision
- LDF:
-
Laser Doppler flowmetry
- NIR:
-
Near infrared
- NO:
-
Nitric oxide
- O2 :
-
Oxygen
- ONH:
-
Optic nerve head
- OPP:
-
Ocular perfusion pressure
- OPs:
-
Oscillatory potentials
- pERG:
-
Pattern reversal electroretinogram
- PO2 :
-
Partial pressure for oxygen
- POBF:
-
Pulsatile ocular blood flow
- Q:
-
Blood flow
- RPE:
-
Retinal pigment epithelium
- RVA:
-
Retinal Vessel Analyzer
- SaO2 :
-
Saturation of oxygen
- V:
-
Velocity
- VM:
-
Valsalva maneuver
References
Kiel JW (1999) Modulation of choroidal autoregulation in the rabbit. Exp Eye Res 69:413–429
Fryczkowski AW (1994) Anatomical and functional choroidal lobuli. Int Ophthalmol 18:131–141
Lovasik JV, Kothe AC, Kergoat H (1993) A comparison of non-invasive methods to derive the mean central retinal artery pressure in man. Optom Vis Sci 70:1005–1011
Guyton AC, Hall JE (1996) Overview of the circulation: medical physics of pressure, flow, and resistance. In: Textbook of medical physiology. WB Saunders, Philadelphia
Al Suwaidi J, Higano ST, Holmes DR Jr et al (2001) Pathophysiology, diagnosis, and current management strategies for chest pain in patients with normal findings on angiography. Mayo Clin Proc 76:813–822
Menkes MS, Matthews KA, Krantz DS et al (1989) Cardiovascular reactivity to the cold pressor test as a predictor of hypertension. Hypertension 14:524–530
Mizushima T, Tajima F, Nakamura T et al (1998) Muscle sympathetic nerve activity during cold pressor test in patients with cerebral vascular accident. Stroke 29:607–612
Lovasik JV, Kergoat H, Riva CE et al (2003) Choroidal blood flow during exercise-induced changes in the ocular perfusion pressure. Invest Ophthalmol Vis Sci 44:2126–2132
Riva CE, Titze P, Hero M et al (1997) Choroidal blood flow during isometric exercises. Invest Ophthalmol Vis Sci 38:2338–2343
Polska E, Simader C, Weigert G et al (2007) Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure. Invest Ophthalmol Vis Sci 48:3768–3774
Lovasik JV, Kergoat H, Gauthier C, Dion I (2009) Regulation of choroidal blood flow fails during cold stimulation. Optom Vis Sci 86:E-abstract 85985
Marinier JA, Kergoat H, Lovasik JV (2000) Increased foveal-choroidal blood flow in man during bilateral cold pressor testing. Optom Vis Sci Suppl 77:231
Lovasik JV, Kergoat H, Greendale C et al (2003) Changes in retinal vessel diameter during a cold pressor test. Optom Vis Sci Suppl 80
Forcier P, Kergoat H, Lovasik JV (1998) Macular hemodynamic responses to short-term acute exercise in humans. Vision Res 38:181–186
Kergoat H, Lovasik JV (1995) Response of parapapillary retinal vessels to exercise. Optom Vis Sci 72:249–257
Pournaras CJ, Rungger-Brändle E, Riva CE et al (2008) Regulation of retinal blood flow in health and disease. Prog Retin Eye Res 27:284–330
Maeda S, Miyauchi T, Kakiyama T et al (2001) Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci 69:1005–1016
Lovasik JV, Kergoat H, Racine N, et al (2007) Neurovascular coupling in long-term joggers versus healthy non-joggers. Invest Ophthalmol Vis Sci 49:E-Abstract 2273
Porth CJ, Bamrah VS, Tristani FE et al (1984) The Valsalva maneuver: mechanisms and clinical implications. Heart Lung 13:507–518
Lovasik JV, Kergoat H, Riva CE, et al (2002) Correlation between the intra-thoracic pressure and choroidal blood flow. Invest Ophthalmol Vis Sci 49:E-Abstract 3315
Benowitz NL (2003) Cigarette smoking and cardiovascular disease: pathophysiology and implications for treatment. Prog Cardiovasc Dis 46:91–111
Rojanapongpun P, Drance SM (1993) The effects of nicotine on the blood flow of the ophthalmic artery and the finger circulation. Graefe’s Arch Ophthalmol 231:371–374
Kaiser HJ, Schoetzau A, Flammer J (1997) Blood flow velocity in the extraocular vessels in chronic smokers. Br J Ophthalmol 81:133–135
Steigerwalt RD Jr, Laurora G, Incandela L et al (2000) Ocular and orbital blood flow in cigarette smokers. Retina 20:394–397
Lafleur J, Lovasik JV (2000) Nicotine modifies reactivity of foveal choroidal blood flow. Optom Vis Sci Suppl 77:155
Balbini APS, Montovani JC (2005) Methods for smoking cessation and treatment of nicotine dependence. Rev Bras Otorrinolaringol 6:820–826
Benowitz NL (2008) Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction. Clin Pharmacol Ther 83:531–541
Delcourt C, Diaz JL, Ponton-Sanchez A et al (1998) Smoking and age-related macular degeneration. The POLA Study. Pathologies Oculaires Liées à l’Age. Arch Ophthalmol 116:1031–1035
Lovasik JV, Kothe AC, Spafford MM (1987) Vascular and neural changes during body inversion: preliminary findings. Can J Optom 49:133–140
Kergoat H, Lovasik JV (1990) The effects of altered retinal vascular perfusion pressure on the white flash scotopic ERG and oscillatory potentials in man. Electroencephalogr Clin Neurophysiol 75:306–322
Lovasik JV (1999) Assessment of the vascular autoregulatory properties in the human choroid with two measurement systems. Optom Vis Sci Suppl 76:246
Kergoat H, Lovasik JV (2005) Seven-degree head-down tilt reduces choroidal pulsatile ocular blood flow. Aviat Space Environ Med 76:930–934
Lovasik JV, Kergoat H (1994) Gravity induced homeostatic reactions in the macular and choroidal vasculature of the human eye. Aviat Space Environ Med 65:1010–1014
Gee W (1985) Ocular pneumoplethysmography. Surv Ophthalmol 29:276–292
Lovasik JV (2004) Choroidal dynamics during rapid vs slow changes in ocular perfusion. Optom Vis Sci Suppl 81:167
Lovasik JV, Gagnon M, Kergoat H (1994) Correlation of the chromaticity of the human ocular fundus with changes in the intraocular pressure, choroidal blood flow, and visual neural function. Surv Ophthalmol 38:S35–S51
Lovasik JV, Kergoat H (1996) Laser Doppler measurements of blood flow in the optic nerve head during cardiac shunting of blood. Optom Vis Sci Suppl 73:77
Koelle JS, Riva CE, Petrig BL et al (1993) Depth of tissue sampling in the optic nerve head using laser Doppler flowmetry. Laser Med Sci 8:49–54
Silverman SE, Trick GL, Hart WM Jr (1990) Motion perception is abnormal in primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 31:722–729
Fitzgerald ME, Vana BA, Reiner A (1990) Control of choroidal blood flow by the nucleus of Edinger-Westphal in pigeons: a laser Doppler study. Invest Ophthalmol Vis Sci 31:2483–2492
Kergoat H, Lovasik JV (1994) Unilateral ocular vascular stress in man and retinal responsivity in the contralateral eye. Ophthalmic Physiol Opt 14:401–407
Lovasik JV, Kergoat H, Gagnon M (2005) Experimentally reduced perfusion of one eye impairs retinal function in both eyes. Optom Vis Sci 82:850–857
Fitzgerald ME, Gamlin PD, Zagvazdin Y et al (1996) Central neural circuits for the light-mediated reflexive control of choroidal blood flow in the pigeon eye: a laser Doppler study. Vis Neurosci 13:655–669
Lovasik JV, Kothe AC (1989) Neural effects of transiently raised intraocular pressure: the scotopic and photopic flash electroretinogram. Clin Vis Sci 4:313–321
Linsenmeier RA (1986) Effects of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol 88:521–542
Kothe AC, Lovasik JV (1988) Neural effects of body inversion: photopic oscillatory potentials. Curr Eye Res 7:1221–1229
Kiss B, Polska E, Dorner G et al (2002) Retinal blood flow during hyperoxia in human revisited: concerted results using different measurement techniques. Microvasc Res 64:75–85
Gilmore ED, Hudson C, Nrusimhadevara RK et al (2007) Retinal arteriolar diameter, blood velocity, and blood flow response to an isocapnic hyperoxic provocation in early sight-threatening diabetic retinopathy. Invest Ophthalmol Vis Sci 48:1744–1750
Jean-Louis S, Lovasik JV, Kergoat H (2005) Systemic hyperoxia and retinal vasomotor responses. Invest Ophthalmol Vis Sci 46:1714–1720
Kergoat H, Lovasik JV, Justino L (2001) Effects of hyperoxia on the blood flow and neural function of the inner retina. Optom Vis Sci Suppl 78:99
Kergoat H, Faucher C (1999) Effects of oxygen and carbogen breathing on choroidal hemodynamics in humans. Invest Ophthalmol Vis Sci 40:2906–2911
Kergoat H, Marinier JA, Lovasik JV (2005) Effects of transient mild systemic hypoxia on the pulsatile choroidal blood flow in healthy young human adults. Curr Eye Res 30:465–470
Geiser MH, Riva CE, Dorner GT et al (2000) Response of choroidal blood flow in the foveal region to hyperoxia and hyperoxia-hypercapnia. Curr Eye Res 21:669–676
Riva CE, Cranstoun SD, Grunwald JE et al (1994) Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci 35:4273–4281
Schmetterer L, Lexer F, Findl O et al (1996) The effect of inhalation of different mixtures of O2 and CO2 on ocular fundus pulsations. Exp Eye Res 63:351–355
Schmetterer L, Wolzt M, Lexer F et al (1995) The effect of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region in healthy young men. Exp Eye Res 61:685–690
Schmetterer L, Findl O, Strenn K et al (1997) Role of NO in the O2 and CO2 responsiveness of cerebral and ocular circulation in humans. Am J Physiol 273:R2005–R2012
Trokel S (1965) Effect of respirator gases upon choroidal hemodynamics. Arch Ophthalmol 73:838–842
Friedman E, Chandra SR (1972) Choroidal blood flow III. Effects of oxygen and carbon dioxide. Arch Ophthalmol 87:70–71
Alm A, Bill A (1972) The oxygen supply to the retina. II. Effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. A study with radioactively labelled microspheres including flow determinations in brain and some other tissues. Acta Physiol Scand 84:306–319
Wang L, Grant C, Fortune B et al (2008) Retinal and choroidal vasoreactivity to altered PaCO2 in rat measured with a modified microsphere technique. Exp Eye Res 86:908–913
Fallon TJ, Maxwell D, Kohner M (1985) Retinal vascular autoregulation in conditions of hyperoxia and hypoxia using the blue field entoptic phenomenon. Ophthalmology 92:701–705
Strenn K, Menapace R, Rainer G et al (1997) Reproducibility and sensitivity of scanning laser Doppler flowmetry during graded changes in PO2. Br J Ophthalmol 81:360–364
Kergoat H, Tinjust D (2004) Neuroretinal function during systemic hyperoxia and hypercapnia in humans. Optom Vis Sci 81:214–220
Faucher C, Kergoat H (2002) Modulation of the scotopic electroretinogram and oscillatory potentials with systemic hyperoxia and hypercapnia in humans. Curr Eye Res 24:376–386
Tinjust D, Kergoat H, Lovasik JV (2002) Investigation of neuroretinal function during mild systemic hypoxia in man. Aviat Space Environ Med 73:1189–1194
Pournaras CJ, Riva CE, Tsacopoulos M et al (1989) Diffusion of O2 in the retina of anesthetized miniature pigs in normoxia and hyperoxia. Exp Eye Res 49:347–360
Kergoat H, Hérard MÈ, Lemay M (2006) RGC sensitivity to mild systemic hypoxia. Invest Ophthalmol Vis Sci 47:5423–5427
Grunwald JE, Hariprasad SM, DuPont J et al (1998) Foveolar choroidal blood flow in age-related macular degeneration. Invest Ophthalmol Vis Sci 39:385–390
Metelitsina TI, Grunwald JE, DuPont JC et al (2008) Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci 49:358–363
Kiryu J, Asrani S, Shahidi M et al (1995) Local response of the primate retinal microcirculation to increased metabolic demand induced by flicker. Invest Ophthalmol Vis Sci 36:1240–1246
McArdle WD, Katch FI, Katch VL (1996) Functional capacity of the cardiovascular system. In: Exercise physiology: energy, nutrition and human performance. Williams & Wilkins, Baltimore
Østerberg G (1935) Topography of the layer of rods and cones in the human retina. Acta Ophthalmol Suppl 6:1–103
Ahnelt PK (1998) The photoreceptor mosaic. Eye 12:531–540
Linsenmeier RA, Padnick-Silver L (2000) Metabolic dependence of photoreceptors on the choroid in the normal and detached retina. Invest Ophthalmol Vis Sci 41:3117–3123
Kergoat H, Lovasik JV, Bitton E (2002) Reduction in choroidal blood flow in the foveal and perifoveal area during dark adaptation. Invest Ophthalmol Vis Sci 49:E-Abstract 3300
Feke GT, Zuckerman R, Green GJ et al (1983) Response of human retinal blood flow to light and dark. Invest Ophthalmol Vis Sci 24:136–141
Riva CE, Grunwald JE, Petrig BL (1983) Reactivity of the human retinal circulation to darkness: a laser Doppler velocimetry study. Invest Ophthalmol Vis Sci 24:737–740
Formaz F, Riva CE, Geiser M (1997) Diffuse luminance flicker increases retinal vessel diameter in humans. Curr Eye Res 16:1252–1257
Falsini B, Riva CE, Logean E (2002) Flicker-evoked changes in human optic nerve blood flow: relationship with retinal neural activity. Invest Ophthalmol Vis Sci 43:2309–2316
Michelson G, Patzelt A, Harazny J (2002) Flickering light increases retinal blood flow. Retina 22:336–343
Longo A, Geiser M, Riva CE (2000) Effect of light on choroidal blood flow in the fovea centralis. Klin Monatsbl Augenheilkd 216:311–312
Garhofer G, Huemer KH, Zawinka C et al (2002) Influence of diffuse luminance flicker on choroidal and optic nerve head blood flow. Curr Eye Res 24:109–113
Lovasik JV, Kergoat H, Wajszilber MA (2005) Blue flicker modifies the subfoveal choroidal blood flow in the human eye. Am J Physiol Heart Circ Physiol 289:H683–H691, Epub 2005 Apr 1
Ibrahim YW, Bots ML, Mulder PG et al (1998) Number of perifoveal vessels in aging, hypertension, and atherosclerosis: the Rotterdam study. Invest Ophthalmol Vis Sci 39:1049–1053
Stanton AV, Wasan B, Cerutti A et al (1995) Vascular network changes in the retina with age and hypertension. J Hypertens 13:1724–1728
Ramrattan RS, van der Schaft TL, Mooy CM et al (1994) Morphometric analysis of Bruch’s membrane, the choriocapillaris, and the choroid in aging. Invest Ophthalmol Vis Sci 35:2857–2864
Nuzzi R, Finazzo C, Grignolo FM (1996) Changes in adrenergic innervation of the choroid during aging. J Fr Ophtalmol 19:89–96
Killingsworth MC (1987) Age-related components of Bruch’s membrane. Graefes Arch Clin Exp Ophthalmol 225:406–412
Curcio CA, Leigh Millican C, Bailey T et al (2001) Accumulation of cholesterol with age in human Bruch’s membrane. Invest Ophthalmol Vis Sci 42:265–274
Moore DJ, Hussain AA, Marshall J (1995) Age-related variation in the hydraulic conductivity of Bruch’s membrane. Invest Ophthalmol Vis Sci 36:1290–1297
Starita C, Hussain AA, Patmore A et al (1997) Localization of the site of major resistance to fluid transport in Bruch’s membrane. Invest Ophthalmol Vis Sci 38:762–767
Polak K, Schmetterer L, Riva CE (2002) Influence of flicker frequency on flicker-induced changes of retinal vessel diameter. Invest Ophthalmol Vis Sci 43:2721–2726
Nagel E, Vilser W (2004) Flicker observation light induces diameter response in retinal arterioles: a clinical methodological study. Br J Ophthalmol 88:54–56
Lovasik JV, Kergoat H, Boutin T, et al (2008) Retinal arterial constriction with aging may modulate vascular perfusion of the eye. Invest Ophthalmol Vis Sci 49:E-Abstract 2090
Kergoat H, Kergoat MJ, Justino L (2001) Age related changes in the flash electroretinogram and oscillatory potentials in individuals 75 years of age and older. J Am Geriatr Soc 49:1–6
Justino L, Kergoat H, Kergoat MJ (2001) Changes in the retinocortical evoked potentials in subjects 75 years of age and older. Clin Neurophysiol 112:1343–1348
Lovasik JV, Kergoat MJ, Justino L et al (2003) Neuroretinal basis of visual impairment in the very elderly. Graefe’s Arch Clin Exp Ophthalmol 241:48–55
Kergoat H, Kergoat MJ, Justino L et al (2001) Age-related topographical changes in the normal human optic nerve head measured by scanning laser tomography. Optom Vis Sci 78:431–435
Acknowledgements
We are grateful to the NSERC, CIHR, FRSQ, and CFI for providing research funds needed to carry out the various projects reported in this chapter. We are particularly grateful for the expert research assistance provided by Mireille Parent throughout our studies in aging. We also acknowledge our research collaborators, the many research assistants and student research assistants that have worked in our labs and the graduate students who have made significant contributions to our research programs. We also thank Dr. Alain Savoie for his beautiful illustrations in Fig. 10.1. Finally, we extend our appreciation to Denis Latendresse, Micheline Gloin, Marc Melillo, Normand Lalonde, and François Vaillancourt for their expert help in graphic design, electronics, computing, and technical design throughout our research at the ÉOUM.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lovasik, J.V., Kergoat, H. (2012). Systemic Determinants. In: Schmetterer, L., Kiel, J. (eds) Ocular Blood Flow. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69469-4_10
Download citation
DOI: https://doi.org/10.1007/978-3-540-69469-4_10
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-69468-7
Online ISBN: 978-3-540-69469-4
eBook Packages: MedicineMedicine (R0)