Abstract
Subretinal fibrosis is defined as the development of either band-like or plaque-like areas of fibrosis underneath the retina due to choroidal neovascularization (CNV) or proliferation of retinal pigment epithelial (RPE) cells and Müller cells. Ophthalmoscopically, it appears white with variable levels of pigmentation and occurs in a number of posterior uveitis and panuveitis conditions.
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References
Adan A, Sanmarti R, Bures A, Casaroli-Marano RP (2007) Successful treatment with infliximab in a patient with Diffuse Subretinal Fibrosis syndrome. Am J Ophthalmol 143:533–534
Amaro MH, Muccioli C, Motta MM (2006) Progressive subretinal fibrosis and multifocal granulomatous chorioretinitis. Arq Bras Oftalmol 69:413–415
Buerk BM, Rabb MF, Jampol LM (2005) Peripapillary subretinal fibrosis: a characteristic finding of multifocal choroiditis and panuveitis. Retina 25:228–229
Calixto N (1988) Histopathologic and immunohistopathologic features of subretinal fibrosis and uveitis syndrome. Am J Ophthalmol 105:220–221
Cantrill HL, Folk JC (1986) Multifocal choroiditis associated with progressive subretinal fibrosis. Am J Ophthalmol 101:170–180
Christmas NJ, Oh KT, Oh DM, Folk JC (2002) Long-term follow-up of patients with serpiginous choroiditis. Retina 22:550–556
Fonseca RA, Dantas MA, Kaga T et al (2001) Subretinal fibrosis and linear streaks in multifocal choroiditis. Arch Ophthalmol 119:142
Gass JD, Margo CE, Levy MH (1996) Progressive subretinal fibrosis and blindness in patients with multifocal granulomatous chorioretinitis. Am J Ophthalmol 122:76–85
Gerstenblith AT, Thorne JE, Sobrin L et al (2007) Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology 114:1201–1204
Kaiser PK, Gragoudas ES (1996) The subretinal fibrosis and uveitis syndrome. Int Ophthalmol Clin 36:145–152
Kim MK, Chan CC, Belfort RJ et al (1987) Histopathologic and immunohistopathologic features of subretinal fibrosis and uveitis syndrome. Am J Ophthalmol 104:15–23
Kuo IC, Rechdouni A, Rao NA et al (2000) Subretinal fibrosis in patients with Vogt-Koyanagi-Harada disease. Ophthalmology 107:1721–1728
Lertsumitkul S, Whitcup SM, Nussenblatt RB, Chan CC (1999) Subretinal fibrosis and choroidal neovascularization in Vogt-Koyanagi-Harada syndrome. Graefes Arch Clin Exp Ophthalmol 237:1039–1045
Lertsumitkul S, Whitcup SM, Chan CC, Nussenblatt RB (2001) Subretinal fibrosis in Vogt-Koyanagi Harada syndrome. Ophthalmology 108:1371
Lim WK, Chee SP, Sng I et al (2004) Immunopathology of progressive subretinal fibrosis: a variant of sympathetic ophthalmia. Am J Ophthalmol 138:475–477
Newland HS, White AT, Greene BM et al (1991) Ocular manifestations of onchocerciasis in a rain forest area of west Africa. Br J Ophthalmol 75:163–169
O’Toole L, Tufail A, Pavesio C (2005) Management of choroidal neovascularization in uveitis. Int Ophthalmol Clin 45:157–177
Palestine AG, Nussenblatt RB, Parver LM, Knox DL (1984) Progressive subretinal fibrosis and uveitis. Br J Ophthalmol 68:667–673
Palestine AG, Nussenblatt RB, Chan CC et al (1985) Histopathology of the subretinal fibrosis and uveitis syndrome. Ophthalmology 92:838–844
Park SP, Ko DA, Chung H, Yu HG (2006) Photodynamic therapy with verteporfin for juxtafoveal choroidal neovascularization in serpiginous choroiditis. Ophthalmic Surg Lasers Imaging 37:425–428
Read RW (2002) Vogt-Koyanagi-Harada disease. Ophthalmol Clin North Am 15:333–341, vii
Read RW, Rechodouni A, Butani N et al (2001) Complications and prognostic factors in Vogt-Koyanagi-Harada disease. Am J Ophthalmol 131:599–606
Read RW, Yu F, Accorinti M et al (2006) Evaluation of the effect on outcomes of the route of administration of corticosteroids in acute Vogt-Koyanagi-Harada disease. Am J Ophthalmol 142:119–124
Song M-H, Roh Y-H (2008) Intravitreal ranibizumab for choroidal neovascularization in serpiginous choroiditis. Eye (Advance Online Publication). doi:10.1038/eye.2008.346
Wang RC, Zamir E, Dugel PU et al (2002) Progressive subretinal fibrosis and blindness associated with multifocal granulomatous chorioretinitis: a variant of sympathetic ophthalmia. Ophthalmology 109:1527–1531
Adán A, Sanmartà R, Burés A, Casaroli-Marano RP (2007) Successful treatment with infliximab in a patient with Diffuse Subretinal Fibrosis syndrome. Am J Ophthalmol 143:533–534
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Case Report 50
Progressive subretinal fibrosis and uveitis syndrom (PPTX 530 kb)
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Moorthy, R.S. (2016). Subretinal Fibrosis. In: Zierhut, M., Pavesio, C., Ohno, S., Orefice, F., Rao, N. (eds) Intraocular Inflammation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75387-2_38
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DOI: https://doi.org/10.1007/978-3-540-75387-2_38
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