Abstract
Sepsis is a complex syndrome characterized by an uncontrolled and deregulated systemic inflammatory response to infection. This is mediated by a broad spectrum of endogenous mediators whose actions result in multiple organ dysfunction distant from the original focus of infection. The kidney is a common ‘victim organ’ of various insults in critically ill patients. Sepsis and septic shock are the dominant causes of acute kidney injury (AKI), accounting for nearly 50 % of episodes of acute renal failure [1]. The incidence of AKI in sepsis increases proportionally with the severity of sepsis, with AKI developing in 19 % of patients with sepsis, 23 % of those with severe sepsis, and 51 % of patients with septic shock [2]. The mortality of sepsis patients with co-existing acute renal failure reaches 70 %, thereby outstripping that of patients with other causes of AKI [3]. Interestingly, even relatively minor increments in serum creatinine levels coincide with markedly increased morbidity and mortality [4], highlighting the potentially important role of kidney dysfunction during the natural history of critical illness. However, the precise understanding of the multifactorial mechanisms of sepsis-induced AKI that would allow the development of new therapeutic strategies to prevent AKI or to hasten its recovery remains a mystery. Here, we review the most recent advances in the understanding of the molecular mechanisms and pathophysiology of sepsis-induced AKI, focusing on renal hemodynamic and microvascular changes and on the importance of a rapidly evolving proteomics approach to evaluating sepsis-induced kidney dysfunction.
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Matejovic, M., Radermacher, P., Thongboonkerd, V. (2008). From Hemodynamics To Proteomics: Unraveling the Complexity of Acute Kidney Injury in Sepsis. In: Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77290-3_53
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DOI: https://doi.org/10.1007/978-3-540-77290-3_53
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