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Langerhans Cell Histiocytosis

  • Chapter
Imaging of Bone Tumors and Tumor-Like Lesions

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Key Points

• Langerhans cell histiocytosis replaces the other descriptive terms for this idiopathic disorder that included histiocytosis X and eosinophilic granuloma.

• LCH is a multisystemic disorder that can affect any organ. Prognosis depends on age of onset and extent of disease involvement.

• Skeletal involvement is common.

• Typically skeletal lesions are well defined. The presence of sclerotic margin is variable.

• Flat bones often have a central button sequestrum.

• A radiographic skeletal survey is the current screening examination of choice, but the use of whole body MR imaging is being increasingly used.

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Author information

Authors and Affiliations

  1. Birmingham Children‘s Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK

    Karl Johnson & David Hobin

Authors
  1. Karl Johnson
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  2. David Hobin
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Editor information

Editors and Affiliations

  1. MRI Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    A. Mark Davies

  2. Section of Musculoskeletal Radiology, Imaging Institute, Diagnostic Radiology/A21, School of Medicine of Case Western Reserve University, Cleveland Clinic Foundation, 9500 Euclid Ave., 44195, Cleveland, OH, USA

    Murali Sundaram

  3. Imaging Department, Royal Orthopaedic Hospital, NHS Foundation Trust, Bristol Road South, Northfield, B31 2AP, Birmingham, UK

    Steven L. J. James

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Johnson, K., Hobin, D. (2009). Langerhans Cell Histiocytosis. In: Davies, A., Sundaram, M., James, S. (eds) Imaging of Bone Tumors and Tumor-Like Lesions. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77984-1_25

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  • DOI: https://doi.org/10.1007/978-3-540-77984-1_25

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