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Combined PET/MR Imaging Using 68Ga-DOTATOC for Radiotherapy Treatment Planning in Meningioma Patients

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Theranostics, Gallium-68, and Other Radionuclides

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 194))

Abstract

Hybrid imaging is beneficial for improved medical diagnosis and therapy planning today. Hybrid imaging describes the prospective correlation of two or more complementary sets of imaging information, such as functional and anatomical image volumes. Correlation can be performed through physically combined imaging modalities, such as PET/CT, SPECT/CT, or PET/MR. Here we present first results from employing fully integrated PET/MR tomography for intensity-modulated radiotherapy (IMRT) treatment planning in patients with meningioma using [68Ga]-DOTATOC as the biomarker of choice. Combined PET/MR offers higher soft tissue contrast and the ability to add functional information to the plain combination of MR-based anatomy and PET-based metabolic and molecular information. Furthermore, fully integrated PET/MR employs novel PET technology that is neither available in PET-only nor PET/CT systems. Despite the current lack of broad clinical evidence, integrated PET/MR may become particularly important and clinically useful for improved, individualized RT therapy planning for brain lesions. In particular, logistical and diagnostic benefits of integrated PET/MR-based treatment planning over treatment planning based on PET/CT data may be expected in meningioma patients.

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Abbreviations

APD:

Avalanche photodiode

CT:

Computed tomography

DCE:

Dynamic contrast enhanced

DOTATOC:

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-d-Phe1-Tyr3-octreotide (TOC)

DWI:

Diffusion-weighted imaging

FDG:

[18F]-Fluorodeoxyglucose

FET:

O-(2-[18F]-Fluoroethyl)-l-tyrosine

GTV:

Gross target volume

IMRT:

Intensity-modulated radiation therapy

MET:

Methionine

MI:

Mutual information

mL:

Milliliter

MRI:

Magnetic resonance imaging

MRS:

Magnetic resonance spectroscopy

OSEM:

Ordered-subsets expectation maximization

p.i.:

Post injection

PET:

Positron emission tomography

PTV:

Planning target volume

RT:

Radiation therapy

SNR:

Signal-to-noise ratio

SPECT:

Single-photon emission computed tomography

TBR:

Tumor-to-blood ratio

TV:

Target volume

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Acknowledgments

NS, SW, GH, MR, AK, BP for help with patient management, data acquisition, image analysis and data interpretation. DT is supported by the European Social Fund and the Ministry of Science, Research, and the Arts Baden-Württemberg. This work was supported by the Imaging Science Institute (ISI) Tübingen. Mirada Imaging, UK (w3.mirada-medical.com): Software fusion and image display.

Duality-of-Interest

T.B. is president and founder of Switzerland-based cmi-experts GmbH. The Imaging Science Institute of Tübingen is supported by Siemens Healthcare.

Author information

Authors and Affiliations

  1. Section for Biomedical Physics, University Hospital for Radiation Oncology, Eberhard-Karls-University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany

    Daniela Thorwarth

  2. University Hospital for Radiation Oncology, Eberhard-Karls-University, Tübingen, Germany

    Arndt-Christian Müller

  3. Department for Diagnostic and Interventional Radiology, Division of Radiology, Eberhard-Karls-University, Tübingen, Germany

    Christina Pfannenberg

  4. CMI Experts GmbH, Pestalozzistr. 3, CH - 8032, Zürich, Switzerland

    Thomas Beyer

Authors
  1. Daniela Thorwarth
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  2. Arndt-Christian Müller
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  3. Christina Pfannenberg
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  4. Thomas Beyer
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Corresponding author

Correspondence to Daniela Thorwarth .

Editor information

Editors and Affiliations

  1. , THERANOSTICS Center for Molecular,, ENETS Center of Excellence, Zentralklinik Bad Berka, Bad Berka, 99437, Germany

    Richard P. Baum

  2. Inst. Kernchemie, Universität Mainz, Fritz-Straßmann-Weg 2, Mainz, 55128, Germany

    Frank Rösch

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Thorwarth, D., Müller, AC., Pfannenberg, C., Beyer, T. (2013). Combined PET/MR Imaging Using 68Ga-DOTATOC for Radiotherapy Treatment Planning in Meningioma Patients. In: Baum, R., Rösch, F. (eds) Theranostics, Gallium-68, and Other Radionuclides. Recent Results in Cancer Research, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27994-2_23

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  • DOI: https://doi.org/10.1007/978-3-642-27994-2_23

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-27993-5

  • Online ISBN: 978-3-642-27994-2

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