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Interleukin-6

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

Interleukin-6 (IL-6) is a multifunctional cytokine produced by both lymphoid and nonlymphoid cells (Kishimoto and Hirano 1988 a, b; Kishimoto 1988; Le and Vilcek 1989). IL-6 has previously been called by a variety of names, such as B-cell stimulatory factor 2 (BSF-2; Hirano et al. 1985), interferon-β2 (IFN-β2; Zilberstein et al. 1986), 26-kDa protein (Haegeman et al. 1986), hybridoma/plasmacytoma growth factor (Van Snick et al. 1986; Nordan and Potter 1986; Van Damme et al. 1987 a), and hepatocyte stimulating factor (HSF; Andus et al. 1987; Gauldie et al. 1987) on the basis of its biological activities. Following the molecular cloning of the cDNAs encoding BSF-2, IFN-β2, and 26-kDa protein (Hirano et al. 1986; Zilberstein et al. 1986; Haegeman et al. 1986), it was found that all these molecules were identical and therefore this molecule was called IL-6. It is now known that IL-6 is a polypeptide mediator regulating the immune response, the acute phase reaction, and hematopoiesis. Furthermore, it has been demonstrated that deregulated production of IL-6 is involved in a variety of chronic inflammatory diseases and certain lymphoid malignancies, especially plasmacytoma/myeloma. In fact, it was demonstrated that unregulated expression of the IL-6 gene in B-lineage cells causes development of a massive plasmacytosis histologically indistinguishable from plasmacytoma in transgenic mice with the immunoglobulin heavy chain enhancer—IL-6 gene (Suematsau et al. 1989).

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Authors
  1. T. Hirano
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  2. T. Kishimoto
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  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Hirano, T., Kishimoto, T. (1990). Interleukin-6. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-49295-2_14

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