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Peyronie’s Disease

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Urology at a Glance

Abstract

Peyronie’s disease (PD) is an acquired benign disease that affects the tunica albuginea of the penis leading to fibrous plaques. The major and most characteristic symptom in affected patients is penile deviation, which may lead to inability for sexual intercourse [1–3]. The prevalence of PD is 3–9 % of adult men, with males between 40 and 70 years being affected predominantly. However, PD also occurs in the younger population under 30 years [2, 4]. The etiology of PD is unknown, but some hypotheses exist. The disease is considered a wound-healing disorder that occurs in genetically susceptible males following repeated penile microtraumata. These microtraumata usually occur during sexual intercourse, without being noticed by the patient. However, PD has a multifactorial background including unregulated deposition of collagen and overexpression of transforming growth factor-β-1, which finally lead to the formation of characteristic penile plaques. Common comorbidities and risk factors for developing PD are diabetes mellitus, hypertension, hyperlipidemia, hypogonadism, smoking, and excessive consumption of alcohol. Dupuytren’s disease is an associated collagen disease, affecting 9–39 % of PD patients [2, 5, 6].

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Author information

Authors and Affiliations

  1. Department of Urology, Technical University of Munich, Rechts der Isar Medical Center, Ismaninger Str. 22, Munich, 81675, Germany

    Georgios Hatzichristodoulou

  2. Department of Urology, Siloah St. Trudpert Hospital, Wilferdinger Str. 67, Pforzheim, 75179, Germany

    Sven Lahme

Authors
  1. Georgios Hatzichristodoulou
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  2. Sven Lahme
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Correspondence to Georgios Hatzichristodoulou .

Editor information

Editors and Affiliations

  1. Dept. of Urology and Urologic Oncology, Medical School of Hanover (MHH), Hannover, Germany

    Axel S. Merseburger

  2. Department of Urology and Urologic Oncol, Medical School of Hanover (MHH), Hannover, Germany

    Markus A. Kuczyk

  3. Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Judd W. Moul

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Hatzichristodoulou, G., Lahme, S. (2014). Peyronie’s Disease. In: Merseburger, A., Kuczyk, M., Moul, J. (eds) Urology at a Glance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54859-8_44

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  • DOI: https://doi.org/10.1007/978-3-642-54859-8_44

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  • Print ISBN: 978-3-642-54858-1

  • Online ISBN: 978-3-642-54859-8

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