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Markers of Inflammation for Prognosis and Control of Therapeutic Success in Patients with Abdominal Sepsis — Options for Using Adjuvant Intravenous Immunoglobulins

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Immunological Screening and Immunotherapy in Critically ill Patients with Abdominal Infections

Abstract

Sepsis is first of all a clinical diagnosis and is based on objective clinical data according to the ACCP/SCCM-definitions from 1991, which defined sepsis as a situation with an identified or obvious infection and the criteria of systemic inflammatory response syndrome (SIRS). These criteria are temperature more than 38.4 °C or less than 36.0 °C, tachycardia of more than 90 heartbeats/minute, tachypnoea of more than 20 breaths/minute or the need for artificial ventilation and a leukocyte count of more than 12000/µl or less than 4000/µl.

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References

  • Alejandria MM, Lansang MA, Dans LF, Mantaring JBV (1999 and update 2000) Intravenous immunoglobulin for treating sepsis and septic shock (Cochrane-review) The Cochrane Library 3 Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C (1993) High serum procalcitonin concentration in patients with sepsis and infection. Lancet 341: 515

    Google Scholar 

  • Becker KL, Nash DR, Silva OL, Snider RH, Moore CF (1981) Increased serum and urinary calcitonin levels in patients with pulmonary disease. Chest 79: 211

    Article  PubMed  CAS  Google Scholar 

  • Beier W (1994) Procalcitonin (ProCt) — ein innovativer Inflammationsparameter mit prognostischen Eigenschaften. Anästh Intensivmed 36: XVIII, (editorial)

    Google Scholar 

  • Bein T, Unertl K (1993) Möglichkeiten and Grenzen von Score-Systemen in der Intensivmedizin. Anästhesiol. Intensivmed. Notfallmed. Schmerzther. 28: 476–483

    CAS  Google Scholar 

  • Bone RC (1991) The pathogenesis of sepsis. Ann Intern Med 115: 457

    PubMed  CAS  Google Scholar 

  • Brunkhorst FM, Forycki ZF, Beier W, Wagner J (1993) Discrimination of infectious and noninfectious etiologies of the adult respiratory distress syndrome (ARDS) with procalcitonin immunoreactivity. Clin Intensive Care 3 (suppl); 12

    Google Scholar 

  • Chen JY (1996) Intravenous immunoglobulin in the treatment of full term and premature newborns with sepsis. J Formos Med Assoc 24: 733–42

    Google Scholar 

  • Concato J, Shah N, Horwitz RI (2000) Randomized, controlled trials, observational studies, and the hierarchy of research design. NEJM; 342 (25): 1887–1892

    Article  PubMed  CAS  Google Scholar 

  • Döcke WD, Randow F, Syrbe U, Krausch D, Asadullah K, Reinke P, Volk HD, Kox W (1997) Monocyte deactivation in septic patients: restoration by IFN-y treatment. Nature Medicine 3: 678–681

    Article  PubMed  Google Scholar 

  • Garbett ND, Munro CS, Cole PJ (1989) Opsonic activity of an new intravenous immunoglobulin preparation: pentaglobin compared with sandoglobulin. Clinical Experimental Immunol, 76: 3–12

    Google Scholar 

  • Goris RJA, Boekhorst TPA, Nuytinck JKS (1985) Multiple organ failure. Arch Surg 118: 1109

    Google Scholar 

  • Grundmann R, Hornung M (1988) Immunoglobulintherapy in patients with endotoxinemia and postoperative sepsis–a prospective randomized study. Progress in clinical and biological Research 339–349

    Google Scholar 

  • Haupt W, Fritsche H, Hohenberger W, Zirngibl H (1996) Selective cytokine release induced by serum and separated plasma from septic patients. Eur J Surg 162: 769

    PubMed  CAS  Google Scholar 

  • Heney D, Lewis IJ, Evans SW, Banks R, Bailey CC, Whicher JT (1992) Interleukin-6 and its relationship to C-reactive protein and fever in children with febrile neutropenia. J Infect Dis 165: 886

    Article  PubMed  CAS  Google Scholar 

  • Heuer HO, Darius H, Lohmann HF, Meyer J, Schierenberg M, Treese N (1991) Platelet-activating factor type activity in plasma from patients with septicemia and other diseases. Lipids 26: 1381

    Article  PubMed  CAS  Google Scholar 

  • Huttemeier PC, Ritter EF, Benveniste H (1993) Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxin rats. Am J Physiol 265: 4767

    Google Scholar 

  • Joyce CD, Fiscus RR, Wang X, Dries DJ, Morris RC, Prinz RA (1990) Calcitonin related peptide levels are elevated in patients with sepsis. Surgery 108: 1097

    PubMed  CAS  Google Scholar 

  • Le Gall JR, Lemeshow S, Saulnier F (1993) A New Simplified Acute Physiology Score ( SAPS II) Based on a European/North American Multicenter Study. JAMA 270 2957–2963

    Article  PubMed  Google Scholar 

  • Marshall JC (2000) Clinical trials of mediator-directed therapy in sepsis: what have we learned? Intensive Care Med. 26: S75–83

    Article  PubMed  Google Scholar 

  • Mimos O, Benoist JF, Edouard AR, Assicot M, Bohoun C, Samii K (1998) Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med 24: 185–188

    Article  Google Scholar 

  • NIH Consensus conference (1990) Intravenous immunoglobulins. Prevention and treatment of disease. JAMA 264: 3189–3193

    Article  Google Scholar 

  • Nylen ES, O’Neill WO, Jordan MH et al. (1992) Serum procalcitonin as an index of inhalation injury in burns. Horm Metab Res 24: 439

    Article  PubMed  CAS  Google Scholar 

  • Opal SM, Cross AS, Bhattacharjee AK, Visvanathan K, Zabriski JB (1999) Immunoprophylaxis against bacterial sepsis. Sepsis 3: 225–234

    Article  Google Scholar 

  • Rangel-Frausto MS, Pittet D, Costigan, RN, Hwang T, Davis, CS, Wenzel, RP (1995) The natural history of the systemic inflammatory response syndrome (SIRS) JAMA, 273: 117–123

    Article  PubMed  CAS  Google Scholar 

  • Reist K, Hilfiker O, Stepniewski MS et al. (1996) Sepsis-Score in der operativen Intensivmedizin. Anästhesiol Intensivmed Notfallmed Schmerzther 31

    Google Scholar 

  • Reith HB, Dittrich H, Haarmann W, Smektala R, Dohle J, Kozuschek W (1996) Adjuvante Therapie der Peritonitis und ihrer septischer Verlaufsformen mit Taurolidin - eine prospektive randomisierte Untersuchung. Chir Gastroenterologie 12: 358

    Article  Google Scholar 

  • Reith HB, Mittelkötter U, Wagner R, Thiede A (2000) Procalcitonin (PCT) in patients with abdominal sepsis. Intensive Care Med. 26: S 165–169

    Google Scholar 

  • Rosman C, Grond J, Buurman WA et al. (1993) Fish oil increases the release of tumor necrosis factor and interleukin-6 and has no effect on the incidence of multiple organ failure in rats with peritonitis. Eur J Surg 159: 563

    PubMed  CAS  Google Scholar 

  • Schedel I, Dreikhausen U, Nentwig B, Hockenschnieder M, Rauthmann D, Balikcioglu S, Coldewey R, Deicher H (1991) Treatment of gram-negative septic shock with an immunoglobulin preparation: a prospective randomized clinical trial. Clinical Care Med, 10: 1104–1113

    Article  Google Scholar 

  • Werdan K (1999) Immunoglobulins in sepsis: therapeutic use of immunoglobulins. Sepsis 3: 239–245

    Article  Google Scholar 

  • Zanetti G, Calandra T (1997) Intravenous immunoglobulins and granulocyte colony-stimulating factor for the management of infection in intensive care units. Curr Opin Crit Care 3: 342–347

    Google Scholar 

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© 2001 Springer-Verlag Berlin Heidelberg

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Reith, H.B., Mittelkötter, U. (2001). Markers of Inflammation for Prognosis and Control of Therapeutic Success in Patients with Abdominal Sepsis — Options for Using Adjuvant Intravenous Immunoglobulins. In: Faist, E. (eds) Immunological Screening and Immunotherapy in Critically ill Patients with Abdominal Infections. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59455-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-59455-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41148-2

  • Online ISBN: 978-3-642-59455-7

  • eBook Packages: Springer Book Archive

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