Skip to main content
SpringerLink
Log in

Cadmium Alters Arterial Baroreflex Control of Heart Rate in the Conscious Rat

  • Conference paper
Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 7))

Abstract

In conscious rats, a single oral dose of cadmium (Cd) chloride (up to 150 mg/kg) does not alter mean arterial pressure, heart rate and pressor response to phenylephrine 3, 7, and 14 days after loading. However, 150 mg/kg of Cd reduce reflex bradycardia and increase centrally mediated vagal decrease in heart rate. Therefore, it is suggested that Cd could modify baroreflex control of heart rate through an impairment of the afferent component of the reflex.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Buccafusco JJ, Brezenoff HE (1979) Pharmacological study of a cholinergic mechanism within the rat posterior hypothalamic nucleus which mediates a hypertensive response. Brain Res 165:295–310

    Article  PubMed  CAS  Google Scholar 

  • Caputi AP, Rossi F, Carney K, Brezenoff HE (1980) Modulatory effect of brain acetylcholine on reflex-induced bradycardia and tachycardia in conscious rats. J Pharmacol Exp Ther 215: 309–316

    PubMed  CAS  Google Scholar 

  • Coleman TG (1980) Arterial baroreflex control of heart rate in the conscious rat. Am J Physiol 238:515–520

    Google Scholar 

  • Kotsonis FN, Klaessen CD (1977) Toxicity and distribution of cadmium administered to rats at sublethal doses. Toxicol Appl Pharmacol 41: 667–680

    Article  PubMed  CAS  Google Scholar 

  • Watkins BE (1980) Effects of cadmium injections on arterial pressure regulation in the rat. Clin Exp Hypertens 2: 153–162

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Occupational Medicine, Faculty of Medicine, University of Messina, Viale Regina Elena, Villa Cappellani, 98100, Messina, Italy

    D. Germanò & G. Romeo

  2. Institute of Pharmacology, Faculty of Medicine, University of Messina, Piazza XX Settembre, 4, 98100, Messina, Italy

    M. Pochiero, G. Costa & A. P. Caputi

  3. CRF, Via Tito Speri 14, 00040, Pomezia, Roma, Italy

    A. Nunziata

Authors
  1. D. Germanò
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Pochiero
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Romeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Nunziata
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. P. Caputi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Department of Pharmacology, Catholic University of the Sacred Heart, Via della Pineta Sacchetti 644, 00168, Rome, Italy

    Paolo Preziosi

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag

About this paper

Cite this paper

Germanò, D., Pochiero, M., Romeo, G., Nunziata, A., Costa, G., Caputi, A.P. (1984). Cadmium Alters Arterial Baroreflex Control of Heart Rate in the Conscious Rat. In: Chambers, P.L., Preziosi, P., Chambers, C.M. (eds) Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals. Archives of Toxicology, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69132-4_63

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-69132-4_63

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-12452-8

  • Online ISBN: 978-3-642-69132-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation