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Secretion and Bulk Flow of Interstitial Fluid

  • Chapter
Physiology and Pharmacology of the Blood-Brain Barrier

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 103))

Abstract

Turnover of interstitial fluid (ISF) in most tissues depends on net fluid exchanges with plasma and lymph. ISF is produced by the process of filtration across the semipermeable capillary endothelium. It is then cleared from the interstitium either by filtration back into the capillary or by drainage with escaped colloids into the lymphatics. The situation in the central nervous system can be expected to differ. The highly impermeable cerebral capillary endothelium, or blood-brain barrier, restricts filtration between plasma and cerebral ISF, there are no lymphatics, and the brain and spinal cord are surrounded by another extracellular fluid, the cerebrospinal fluid (CSF).

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Authors
  1. H. F. Cserr
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  2. C. S. Patlak
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Editors and Affiliations

  1. Physiology Group Biomedical Sciences Division King’s College London, University of London, Strand, WC2R 2LS, London, Great Britain

    Michael W. B. Bradbury M.A., D.M. (Oxon)

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© 1992 Springer-Verlag Berlin Heidelberg

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Cserr, H.F., Patlak, C.S. (1992). Secretion and Bulk Flow of Interstitial Fluid. In: Bradbury, M.W.B. (eds) Physiology and Pharmacology of the Blood-Brain Barrier. Handbook of Experimental Pharmacology, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76894-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-76894-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76896-5

  • Online ISBN: 978-3-642-76894-1

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