Abstract
Acute renal failure (ARF) is a clinical entity in which kidney function is abruptely interrupted. Under normal circumstances, standard hemodialysis techniques are able to provide efficient substitutive therapy, and outcome is favorable in a large proportion of patients [1]. However, when ARF is associated with multiple organ system dysfunction (MODS) or other pathologic events, patients are generally followed in intensive care units (ICU) and alternative renal replacement therapies are required [2]. Critically ill patients are in fact characterized by severe cardiovascular, respiratory and metabolic instability that require a treatment able to maintain homeostasis without major derangements generated by the therapy itself [3]. Furthermore, when ARF is part of the septic syndrome, treatment must be oriented towards protection of the native kidneys from further injury and the possible removal of circulating mediators of the inflammatory stimulation [4]. In these patients, continuous renal replacement therapies might provide the best compromise between efficiency and clinical tolerance [5].
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Ronco, C., Bellomo, R. (1996). Continuous High Flux Dialysis: An Efficient Renal Replacement. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_55
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DOI: https://doi.org/10.1007/978-3-642-80053-5_55
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