Summary
1.19 patients (38 eyes) with glaucoma or ocular hypertension, were treated during 6 months with metoprolol 3% eye drops twice daily. The intraocular pressure was significantly lowered by this drug in all the patients. The mean intraocular decrease over a 6 months period was 28.30%.
2. 15 patients (30 eyes) of the 19 patients treated with metoprolol, continued their treatment with timolol 0.5% eye drops twice daily for an other 6 months period. The intraocular pressure was lowered by 26.80% in this group.
3. 22 patients (42 eyes) were treated with timolol 0.5% eye drops twice daily during 6 months. The intraocular pressure was lowered by 30.55%.
There is no significant difference between the eye pressure lowering effect of metoprolol and timolol on long-term observation. The average decrease of eye pressure with both drugs is between 25% and 30%.
We thank S. De Bie (Department of Human Genetics) and J. Kint (Pediatric Department) for their help in the statistical work
Metoprolol eye-drops at 3% made by Astra (Goteborg, Sweden) for investigational use only
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alm A, Wickström CP, Ekström C, Öhman L (1979) The effect of metoprolol on intra-ocular pressure in glaucoma. A pilot study. Acta Ophthalmol (Copenh) 57:236–241
Buchell J, Aeschlimann J, Gloor B (1980) Die Wirkung von Metoprolol-Augentropfen auf den Augeninnendruck. Klin Monatsbl Augenheilkd 177:146–150
Collignon-Brach J, Weekers R (1981) Métoprolol et timolol. Étude comparative. J Fr Ophthalmol 4:275–278
Krieglstein GK (1978) Die Wirkung von Metoprololtartrat auf den Augendruck. Eine Doppelblindstudie der Dosis-Wirkungs-Beziehungen. Klin Monatsbl Augenheilkd 173:632–637
Krieglstein GK (1981) The long-term ocular and systemic effects of topically applied metoprolol tartrate in glaucoma and ocular hypertension. Acta Ophthalmol (Copenh) 59:15–20
Merté HJ, Merkle W (1980) Beeinflussung des Augeninnendruckes des Augengesunden nach Einnahme von Propranolol und Metoprolol. Klin Monatsbl Augenheilkd 176:13–15
Ros FE, Dake CL, Nagelkerke NJD, Greve EL (1978) Metoprolol eye drops in the treatment of glaucoma. A double-blind single-dose trial of a beta-adrenergic blocking Drug. Albrecht Von Graefes Arch Klin Exp Ophthalmol 206: 247–254
Urner-Bloch U, Buchell J, Eltz H, Gloor B, Aeschlimann J (1980) Klinische Prüfung verschiedener am adrenergen System angreifender Glaukom-Medikamente. Klin Monatsbl Augenheilkd 176:555–557
Weekers R, Collignon-Brach J (1981) Béta-stimulants et béta-bloquants. Leur place dans le traitement médical du glaucome à angle ouvert. J Fr Ophthalmol 4:149–155
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 J.F. Bergmann Verlag, München
About this paper
Cite this paper
Van Oye, R., De Sutter, E. (1982). Long-term Effect of Topical Metoprolol in Glaucoma and Ocular Hypertension. Comparison with Timolol. In: Krieglstein, G.K., Leydhecker, W. (eds) Medikamentöse Glaukomtherapie. Symposion der Deutschen Ophthalmologischen Gesellschaft vom 22. bis 24. April 1982 in Würzburg. J.F. Bergmann-Verlag. https://doi.org/10.1007/978-3-642-80502-8_26
Download citation
DOI: https://doi.org/10.1007/978-3-642-80502-8_26
Publisher Name: J.F. Bergmann-Verlag
Print ISBN: 978-3-8070-0333-7
Online ISBN: 978-3-642-80502-8
eBook Packages: Springer Book Archive