Abstract
Colorectal carcinoma (CRCa) is the most frequently encountered malignant neoplasm in the United States, which ultimately kills almost exclusively because of systemic dissemination in more than 50% of those manifesting the disease (Welch and Donaldson 1974). It is obvious that better means for systemic control of this disease are needed. The design of this study was influenced by (a) dissatisfaction with the results of postoperative adjuvant chemotherapy in CRCa, (b) the many theoretical considerations along with some experimental and clinical studies suggesting that chemotherapy might become more effective if given before operation rather than after it, and (c) evidence suggesting that anticoagulation might hinder tumor growth. This study was recently reported in detail (Papaioannou et al. 1985) and is presented here in shortened form.
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© 1986 Springer-Verlag Berlin Heidelberg
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Papaioannou, A.N. et al. (1986). Chemotherapy with or Without Anticoagulation as Initial Management of Patients with Operable Colorectal Cancer: A Prospective Study with at Least 5 Years Follow-up. In: Ragaz, J., Band, P.R., Goldie, J.H. (eds) Preoperative (Neoadjuvant) Chemotherapy. Recent Results in Cancer Research, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82671-9_15
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DOI: https://doi.org/10.1007/978-3-642-82671-9_15
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