Abstract
Intrinsic errors of skeletal development are individually rare but of clinical importance because of their overall frequency and their impact on patients’ lives. Conventionally they are divided into malformations — defects of single bone — and dysplasias — systemic defects of chondro-osseous tissue. Depending on the type of surveillance system, limb reduction defects, one major category of skeletal malformations, are recognized in 3.1-6.9 of 10,000 newborns (Eurocat 2002; Makhoul et al. 2003; McGuirk et al. 2001; Stoll et al. 2000). Due to spontaneous or induced fetal loss, the prevalence in fetuses is higher, up to 15.7 of 10,000 (A. Queisser 2003, personal communication). The overall prevalence of neonatally manifested skeletal dysplasias is about 2 out of 10,000, half of them lethal (Andersen 1989; Cobben et al. 1990; Connor et al. 1985; Rasmussen et al. 1996).
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Schumacher, R., Seaver, L.H., Spranger, J. (2004). Introduction. In: Fetal Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05374-4_1
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DOI: https://doi.org/10.1007/978-3-662-05374-4_1
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