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Effects of Progesterone and Testosterone on ICH-Induced Brain Injury in Rats

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Intracerebral Hemorrhage Research

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 111))

Abstract

Studies have shown that progesterone reduces brain injury, whereas testosterone increases lesion size after ischemic stroke. This study examined the effects of progesterone and testosterone on intracerebral hemorrhage (ICH)-induced brain injury.

Male Sprague-Dawley rats received an injection of 100 μL autologous whole blood into the right basal ganglia. Progesterone (16 mg/kg), testosterone (15 mg/kg) or vehicle was given intraperitoneally 2 h after ICH. Behavioral tests were performed, and the rats were killed after 24 h for brain edema measurement.

Perihematomal brain edema was reduced in progesterone-treated rats compared to vehicle-treated rats (p < 0.05). Progesterone also improved functional outcome following ICH (p < 0.05). Testosterone treatment did not affect perihematomal edema formation, but resulted in lower forelimb placing score (p < 0.05).

In conclusion, progesterone can reduce brain edema and improve functional outcome, whereas testosterone may have a deleterious effect after ICH in male rats.

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Acknowledgment

This study was supported by grants NS-017760, NS-039866 and NS-057539 from the National Institutes of Health (NIH) and 0755717Z, 0840016N from the American Heart Association (AHA). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and AHA.

Conflict of interest statement We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Zheng Chen, Guohua Xi & Richard F. Keep

  2. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China

    Zheng Chen, Ying Mao & Ya Hua

  3. Department of Neurosurgery, University of Michigan, Room 5018, BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109–2200, USA

    Ya Hua

Authors
  1. Zheng Chen
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  2. Guohua Xi
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  3. Ying Mao
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  4. Richard F. Keep
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  5. Ya Hua
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Correspondence to Ya Hua .

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Editors and Affiliations

  1. , Neurosurgery, Physiology, Loma Linda University, Campus Street 11041, Loma Linda, 92530, USA

    John Zhang

  2. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    Austin Colohan

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© 2011 Springer-Verlag/Wien

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Chen, Z., Xi, G., Mao, Y., Keep, R.F., Hua, Y. (2011). Effects of Progesterone and Testosterone on ICH-Induced Brain Injury in Rats. In: Zhang, J., Colohan, A. (eds) Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol 111. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0693-8_48

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  • DOI: https://doi.org/10.1007/978-3-7091-0693-8_48

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-0692-1

  • Online ISBN: 978-3-7091-0693-8

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