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The Role of Ceramide-1-Phosphate in Biological Functions

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Sphingolipids: Basic Science and Drug Development

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 215))

Abstract

In mammalian cells, cermide-1-phosphate (C1P) is produced via the ATP-dependent mechanism of converting ceramide to C1P by the enzyme, ceramide kinase (CERK). CERK was first described as a calcium-stimulated lipid kinase that co-purified with brain synaptic vesicles, and to date, CERK is the only identified mammalian enzyme known to produce C1P in cells. C1P has steadily emerged as a bioactive sphingolipid involved in cell proliferation, macrophage migration, and inflammatory events. The recent generation of the CERK knockout mouse and the development of CERK inhibitors have furthered our current understanding of CERK-derived C1P in regulating biological processes. In this chapter, the history of C1P as well as the biological functions attributed to C1P are reviewed.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, 1101 East Marshall Street, 980614, Richmond, VA, 23298-0614, USA

    L. Alexis Hoeferlin, Dayanjan S. Wijesinghe & Charles E. Chalfant

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  1. L. Alexis Hoeferlin
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  2. Dayanjan S. Wijesinghe
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  3. Charles E. Chalfant
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Correspondence to Charles E. Chalfant .

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  1. , Department of Molecular Biology, University of Duisburg-Essen, Hufelandstraße 55, Essen, 45122, Germany

    Erich Gulbins

  2. Division of Pulmonary, Allergy, Critical, Department of Medicine, Indiana University School of Medicine, W. Walnut Street 980, Indianapolis, 46202, Indiana, USA

    Irina Petrache

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Hoeferlin, L.A., Wijesinghe, D.S., Chalfant, C.E. (2013). The Role of Ceramide-1-Phosphate in Biological Functions. In: Gulbins, E., Petrache, I. (eds) Sphingolipids: Basic Science and Drug Development. Handbook of Experimental Pharmacology, vol 215. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1368-4_8

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