Abstract
Callosotomy and hemispherotomy are both neurosurgical procedures available to disconnect the cerebral hemisphere. Callosotomy disconnects the hemispheres partly or completely, one from the other, while hemispherotomy disconnects one hemisphere from the rest of the central nervous system. Callosotomy has been in the neurosurgical armamentarium for 60 years, but gained clear recognition as a valuable surgical procedure in the treatment of epilepsy during the seventies. While anatomical hemispherectomy in humans was first carried out more than seventy five years ago, the concept of disconnection rather than removal of the cerebral hemisphere for control of seizures, became reality twenty five years ago with the introduction of functional hemispherectomy. With the hemispherotomy technique, the emphasis is placed on greater disconnection and smaller excision.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adams CBT (1983) Hemispherectomy: a modification. J Neurol Neurosurg Psychiatry 46: 617–619
Aicardi J, Chevrie JJ (1971) Myoclonic epilepsies of childhood. Neuopaediatrie 3: 177–190
Amacher AL (1976) Midline commissurotomy for the treatment of some cases of intractable epilepsy. Childs Brain 2: 54–58
Andermannn F, Olivier A, Gotman J, Sergent J (1988) Callosotomy for the treatment of patients with intractable epilepsy and the Lennox-Gastaut syndrome. In: Niedermeyer E, Degen R (eds) The Lennox-Gastaut syndrome. Allan R Liss, New York, pp 361–376
Apuzzo MLJ, Chikovani OK, Gott PS (1982) Transcallosal, interfornicial approaches for lesions affecting the third ventricle: surgical considerations and consequences. Neurosurgery 10: 547–554
Asanuma H, Okuda O (1962) Effect of transcallosal volleys on pyramidal tract cell activity of cat. J Neurophysiol 25: 198–208
Avila JO, Radvany J, Huck FR, Pires de Camargo CH, Marino R, Ragazzo PC, Riva D (1980) Anterior callosotomy as a substitute for hemispherectomy. Acta Neurochir (Wien) 30: 137–143
Bancaud J, Talairach J, Bonis A, Sc/haub D, Szikla G, Morel P, Bordas-Ferer M (1965) La Stéréo-encéphalographie dans l’épilepsie. Masson, Paris
Beardsworth ED, Adams CBT (1988) Modified hemispherectomy for epilepsy: early results in 10 cases. Br J Neurosurg 2: 73–84
Berg AT, Vickrey BG (1998) Outcome measures. In: Engel J, Pedley TA (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven Publishers, Philadelphia, pp 1891–1899
Blomstedt GC (1987) Postoperative aseptic meningitis. Acta Neurochir (Wien) 89: 122–116
Blume WT, David RB, Gomez MR (1973) Generalized sharp and slow wave complexes. Associated clinical features and long-term follow-up. Brain 96: 289–306
Blume WT (1978) Clinical and electoencephalographic correlates of the multiple independent spike foci pattern in children. Ann Neurol 4: 541–547
Blume WT (1984) Corpus callosum section for seizure control: rationale and review of experimental and clinical data. Cleve Clin Q 51: 319–332
Blume WT, Aicardi J, Dreifuss FE (1993) Syndromes not amenable to resective surgery. In: Engel J (ed) Surgical treatment of the epilepsies, 2nd edn. Raven Press, New York, pp 103–118
Blume WT (1997) Corpus callostomy: a critical review. In: Tuxhorn I, Holthausen H, Boenigk H (eds) Paediatric epilepsy syndromes and their surgical treatment. John Libbey & Co, London, pp 815–829
Bogen JE, Vogel PJ (1962) Cerebral commissurotomy in man: preliminary case report. Bull Los Angeles Neurol Soc 27: 139–172
Bogen JE, Vogel PJ (1963) treatment of generalized seizures by cerebral commissurotomy. Surg Forum 14: 431–433
Bogen JE, Fischer ED, Vogel PJ (1965) Cerebral commissurotomy. A second case report. JAMA 194: 1328–1329
Bogen JE, Sperry RW, Vogel PJ (1969) Commissural section and propagation of seizures. In: Jasper HH, Ward AA, Pope A (eds) Basic mechanisms of the epilepsies. Little, Brown, & Co, Boston, pp 439–440
Bogen JE (1997) The neurosurgeon’s interest in the corpus callosum. In: Greenblatt SH, Dagi TF, Epstein MH (eds) A history of neurosurgery in its scientific and professional context. The American Association of Neurological Surgeons, Park Ridge, pp 489–498
Brian JE, Deshpande JK, MacPherson RW (1990) Management of cerebral hemispherectomy in children. J Clin Anesth 2: 91–95
Cabiese F, Jeni R, Landa R (1957) Fatal brain-stem shift following hemispherectomy. J Neurosurg 14: 74–91
Cairns H (1951) Hemispherectomy in the treatment of infantile hemiplegia. Lancet 2: 411–415
Carson BS, Javedan SP, Freeman JM, Vining EP, Zuckerberg AL, Lauer JA, Guarnieri M (1996) Hemispherectomy: a hemidecortication approach of 52 cases. J Neurosurg 84: 903–911
Catier J, Choux M, Cordeau JP, Dimov S, Riche D, Eberhard A, Naquet R (1970) Résultats préliminaires des effets électrographiques de la section du corps calleux chez le Papio papio photosensible. Rev Neurol 122: 521–522
Cendes F, Ragazzo PC, da Costa V, Martins LF (1993) Corpus callosotomy in treatment of medically resistant epilepsy: preliminary results in a pediatric population. Epilepsia 34: 910–917
Collins RC, Kennedy C, Sokoloff L, Plum F (1976) Metabolic anatomy of focal motor seizures. Arch Neurol 33: 536–542
Crowell RM, Ajmone Marsan C (1972) Topographical distribution and patterns of unit activity during electrically induced after-discharge. Electroencephalogr Clin Neurophysiol 31: 59–73
Curtis HJ, Bard P (1939) intercortical connections of the corpus callosum as indicated by evoked potentials. Am J Physiol 126: 473
Dandy WE (1936) Operative experiences in cases of pineal tumors. Arch Surg 33: 19–46
Dandy WE (1928) Removal of right cerebral hemisphere for certain tumors with hemiplegia. JAMA 90: 823–825
Davies KG, Maxwell RE, French LA (1993) Hemispherectomy for intractable seizures: long-term results in 17 patients followed for up to 38 years. J Neurosurg 78: 733–740
Delalande O (1996) Chirurgie de l’épilepsie chez l’enfant. Techniques chirurgicales. Soins Chirurgie 178: 18–21
Delalande O, Pinard JM, Basdevant C, Gauthe M, Plouin P, Dulac O (1992) Hemispherotomy: a new procedure for central disconnection. Epilepsia 33 [Suppl] 3: 99–100
Duchowny MS (1989) Surgery for intractable epilepsy: issues and outcome. Pediatrics 84: 886–894
Dunn LT, Miles JB, May PL (1995) Hemispherectomy for intractable seizures: a further modification and early experience. Br J Neurosurg 9: 775–783
Engel J, Wolfson L, Brown L (1978) Anatomical correlates of electrical and behavioral events related to amygdaloid kindling. Ann Neurol 3: 538–544
Engel J (1987) Outcome with respect to epileptic seizures. In: Engel J (ed) Surgical treatment of the epilepsies. Raven Press, New York, pp 553–571
Engel J, Van Ness PC, Rasmussen TB, Ojemann LM (1993) Outcome with respect to epileptic seizures. In: Engel J (ed) Surgical treatment of the epilepsies, 2nd edn. Raven Press, New York, pp 609–621
Erickson TC (1940) Spread of the epileptic discharge. An experimental study of the after-discharge induced by electrical stimulation of the cerebral cortex. Arch Neurol Psychiatry 43: 429–452
Falconer MA, Wilson PJE (1969) Complications related to delayed hemorrhage after hemispherectomy. J Neurosurg 30: 413–414
Ferguson SM, Rayport M, Corrie WS (1985) Neuropsychiatric observation on behavioral consequences of corpus callosum section for seizure control. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 501–514
Fischer RS, Prince DA (1977) Spike-wave rhythms in cat cortex induced by parenteral penicillin. Electroencephalographic features. Electroencephalogr Clin Neurophysiol 42: 608–624
French LA, Johnson DR, Brown IA, Van Bergen FB (1955) Cerebral hemispherectomy for control of intractable convulsive seizures. J Neurosurg 12: 154–164
Fuiks KS, Wyler AR, Hermann BP, Somes G (1991) Seizure outcome from anterior and complete callosotomy. J Neurosurg 74: 573–578
Gardner WJ (1933) Removal of the right cerebral hemisphere for infiltrating glioma. JAMA 12: 154–164
Gastaut H, Roger J, Soulayrol CA, Tassinari CA, Dravet C (1966) Childhood epileptic encephalopathy with diffuse slow spike-waves (otherwise known as «petit mal variant») or Lennox syndrome. Epilepsia 7:139–179
Gates JR, Leppik IE, Yap J, Gumnit RJ (1984) Corpus callosotomy: clinical and electroencephlographic effects. Epilepsia 25: 308–316
Gates JR, Maxwell R, Leppik IE, Fiol ME, Gumnit RJ (1985) Electroencephlographic and clinical effects of total callosotomy. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 281–301
Gates JR, Rosenfeld WE, Maxwell RE, Lyons RE (1987) response of multiple seizure types to corpus callosum section. Epilepsia 28: 28–34
Gates JR, Ritter FJ, Ragazzo PC, Reeves AG, Nordgren RE (1990) Corpus callosum section in children: seizure response. J Epilepsy 3: 271–278
Gates JR (1992) Corpus callosotomy candidacy. In: Lüders H (ed) Epilepsy surgery. Raven Press, New York, pp 119–125
Geoffroy G, Lassonde M, Delisle F, Decarie M (1983) Corpus callosotomy for control of intractable epilepsy in children. Neurology 33: 891–897
Geschwind DH, Jacobini M, Mega MS, Zaidel DW, Cloughesy T, Zaidel E (1995) Alien hand syndrome: interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum. Neurology 45: 802–808
Gilliam F, Wyllie E (1997) Functional outcome of children following corpus callosum section. In: Tuxhorn I, Holthausen H, Boenigk H (eds) Paediatric epilepsy syndromes and their surgical treatment. John Libbey & Co, London, pp 850–853
Gloor P, Quesney LF, Zumstein H (1977) Pathophysiology of generalized penicillin epilepsy in the cat: the role of cortical and subcortical structures. II. Topical application of penicillin to the cerebral cortex and to subcoretical structures. Electroencephalogr Clin Neurophysiol 43: 73–94
Gloor P, Avoli M, Kostopoulos G (1990) Thalamocortical relationships in generalized epilepsy with bilaterally synchronous spike-and-wave discharge. In: Avoli M, Gloor P, Kostopoulos G, Naquet R (eds) Generalized epilepsy, neurobiological approaches. Birkhauser, Boston, pp 190–212
Goldring S (1972) The role of prefrontal cortex in grand mal convulsion. Arch Neurol 26: 109–119
Gotman J (1983) Measurement of small time differences between EEG channels: method and application to epileptic seizure propagation. Electroencephalogr Clin Neurophysiol 56: 501–514
Griffith HB (1967) Cerebral hemispherectomy for infantile hemiplegia in the light of late results. Ann R Coll Surg Engl 41: 183–201
Harbaugh RE, Wilson DH, Reeves AG, Gazzaniga MS (1983) Forebrain commissurotomy for epilepsy: review of 20 consecutive cases. Acta Neurochir (Wien) 68: 263–275
Hoffman HJ (1997) Hemispherectomy. Paediatric epilepsy syndromes and their surgical treatment. In: Tuxhorn I, Holthausen H, Boenigk H (eds) John Libbey, pp 739–742
Holthausen H, May TW, Adams CBT et al (1997) Seizures post-hemispherectomy. Paediatric epilepsy syndromes and their surgical treatment. In: Tuxhorn I, Holthausen H, Boenigk H (eds) John Libbey, pp 749–773
Huck FR, Radvany J, Avila JO, Pires de Camargo CH, Marino R, Ragazzo PC, Riva D, Arlant P (1980) Anterior callosostomy in epileptics with multiform seizures and bilateral synchronous spike and wave EEG pattern. Acta Neurochir [Suppl] (Wien) 30: 127–135
Ignelzi RJ, Bucy PC (1968) Cerebral hemidecortication in the treatment of infantile cerebral hemiatrophy. J Nerv Ment Dis 147: 14–30
Isaacson RL, Schwartz H, Persoff N, Pinson L (1971) The role of the corpus callosum in the establishment of areas of secondary epileptiform activity. Epilepsia 12: 133–146
Jasper H, Kershman J (1941) Eclectroencephalographic classification of the epilepsies. Arch Neurol Psychiatry 45: 903–943
Jasper HH, Droogleever-Fortuyn J (1947) Experimental studies on the functional anatomy of petit mal epilepsy. Proc Assoc Res Nerv Ment Dis 26: 272–298
Kopeloff N, Kennard MA, Pacalla BL, Kopeloff LM, Chusid JG (1950) Section of corpus callosum in experimental epilepsy in the monkey. Arch Neurol Psychiatry 63: 719–727
Krynauw RA (1950) Infantile hemiplegia treated by removing one cerebral hemisphere. J Neurol Neurosurg Psychiatry 13: 243–267
Kusske JA, Rush JL (1978) Corpus callosum and propagation of afterdischarge to contralateral cortex and thalamus. Neurology 28: 905–912
Laine E, Pruvot P, Osson D (1964) Résultats éloignés de l’hémisphérectomie dans les cas d’hémiatrophie cérébrale infantile génératrice d’épilepsie. Neurochirurgie 10: 507–522
Lemieux JF, Blume WT (1986) Topographical evolution of spike-wave complexes. Brain Res 373: 275–287
Lindsay J, Ounsted C, Richards P (1987) Hemispherectomy for childhood epilepsy: a 36 years study. Dev Med Child Neurol 29: 592–600
Luessenhop AJ (1970) Interhemispheric commissurotomy as an alternate to hemispherectomy for control of intractable seizures. Am Surg 36: 265–268
Luessenhop AJ, dela Cruz TC, Fenichel GM (1970) Surgical disconnection of the cerebral hemispheres for intractable seizures: results in infancy and childhood. JAMA 213: 1630–1636
Madsen JR, Carmant L, Holmes GL, Black PMcL (1995) Corpus callosotomy in children. Neurosurg Clin North Am 6: 541–548
Mamelak AN, Barbaro NM, Walker JA, Laxer KD (1993) Corpus callosotomy: a quantitative study of the extent of resection, seizure control, and neuropsychological outcome. J Neurosurg 79: 688–695
Marcus EM, Watson CW (1966) Bilateral synchronous spike wave electrographic patterns in the cat. Interaction of bilateral cortical foci in the intact, the bilateral cortical-callosal, and adiencephalic preparation. Arch Neurol 14: 601–610
Marcus EM, Watson CW (1968) Symmetrical epileptogenic foci in monkey cerebral cortex. Mechanisms of interaction and regional variations in capacity for synchronous discharges. Arch Neurol 19: 99–116
Marino R, Ragazzo PC (1985) Selection criteria and results of selective partial callosotomy. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 281–301
Marino R, Radvany J, Huck F, de Camargo CHP, Gronich G (1990) Selective EEG-guided microsurgical callosotomy for refractory generalized epilepsy. Surg Neurol 34: 219–228
Markand ON (1977) Slow spike-wave activity in EEG and associated clinical features: often called «Lennox» or «Lennox-Gastaut» syndrome. Neurology 27: 746–757
Matheson JM, Truskett P, Davies MA, Vonau M (1993) Hemispherectomy: a further modification using omentum vascularized free flaps. Aust NZ J Surg 63: 646–650
McKenzie KG (1938) The present status of a patient who had the right cerebral hemisphere removed. JAMA 111: 168
Meagher-Villemure K (1997) Neuropathological findings in paediatric functional hemispherectomies. Paediatric epilepsy syndromes and their surgical treatment. In: Tuxhorn I, Holthausen H, Boenigk H (eds) John Libbey, pp 799–811
Morillo LE, Ebner TJ, Bioedel JR (1982) The early involvement of subcortical structures during the development of a cortical seizure focus. Epilepsia 23:571–585
Musgrave J, Gloor P (1980) The role of the corpus callosum in bilateral interhemispheric synchrony of spike and wave discharge in feline generalized penicillin epilepsy. Epilepsia 21: 369–378
Mutani R, Bergamini L, Fariello R, Quattrocolo G (1973) Bilateral synchrony of epileptic discharge associated with chronic asymmetrical cortical foci. Electroencephalogr Clin Neurophysiol 34: 53–59
Nakasu Y, Isozumi T, Nioka H, Handa J (1991) Mechanism of mutism following the transcallosal approach to the evntricles. Acta Neurochir (Wien) 110: 146–153
Nordgren RE, Reeves AG, Viguera AC, Roberts DW (1991) Corpus callosotomy for intractable seizures in the pediatric age group. Arch Neurol 48: 364–372
Noriega-Sanchez A, Markand ON (1976) Clinical and electroencephalographic correlation of independent multifocal spike discharges. Neurology 26: 667–672
Obrador A (1952) About the surgical technique of hemispherectomy in cases of cerebral hemiatrophy. Acta Neurochir (Wien) 3: 57–63
Oguni H, Olivier A, Andermann F, Comair J (1991) Anterior callosotomy in the treatment of medically intractable epilepsies: a study of 43 patients with a mean follow-up of 39 months. Ann Neurol 30: 357–364
Oppenheimer DR, Griffith HB (1966) Persistent intracranial bleeding as a complication of hemispherectomy. J Neurol Neurosurg Psychiatry 9: 229–240
Ottino CA, Meglio M, Rossi GF, Tercero E (1971) An experimental study of the structure mediating bilateral synchrony of epileptic discharges of cortical origin. Epilepsia 12: 299–311
Peacock WJ (1995) Hemispherectomy for the treatment of intractable seizures in childhood. Neurosurg Clin North Am 6: 549–563
Peacock WJ, Wehby-Grant MC, Shields WD, Shewmon DA, Chugani HT, Sanka R, Vinters HV (1996) Hemispherectomy for intractable seizures in children: a report of 58 cases. Childs Nerv Syst 12:376–84
Pellegrini A, Musgrave J, Gloor P (1979) Role of afferent input of subcortical origin in the genesis of bilaterally synchronous epileptic discharges of feline generalized penicillin epilepsy. Exp Neurol 64: 155–173
Pilcher WH, Ojemann GA (1993) Complications of epilepsy surgery. In: Post KD, Friedman E, McCormick P (eds) Postoperative complications in intracranial surgery. Thieme, Stuttgart, pp 157–165
Purves SJ, Wada JA, Woodhurst WB, Moyes PD, Strauss E, Kosaka B, Li D (1988) Results of anterior corpus callosum section in 24 patients with medically intractable seizures. Neurology 38: 1194–1201
Purves WJ, Wada JA, Woodhurst WB (1995) Corpus callosum section for complex partial seizures. In: Reeves AG, Roberts DW (eds) Epilepsy and the corpus callosum, 2nd edn. Plenum Press, New York, pp 175–182
Raffel C, Kongelbeck SR, Snead OC (1992) Corpus callosotomy for intractable epilepsy in children. Pediatr Neurosurg 18: 305–309
Ransohoff J, Hess W (1973) Discussion in: Rasmussen T. Post-operative superficial cerebral hemosiderosis of the brain, its diagnosis, treatment and prevention. Am Neurol Assoc 98: 133–137
Rasmussen T (1983) Hemispherectomy for seizures revisited. Can J Neurol Sei 10, 7
Rayport M, Corrie WS, Ferguson SM (1985) Corpus callosum section for control of clinically and electroencephalographically classified intractable seizures. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 329–337
Reeves AG, O’Leary PM (1985) Total corpus callosotomy for control of medically intractable epilepsy. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 269–280
Reeves AG, Risse G (1985) Neurological effects of callosotomy. In: Reeves AG, Roberts DW (eds) Epilepsy and the corpus callosum, 2nd ed. Plenum Press, New York, pp 241–251
Reutens DC, Bye AM, Hopkins IJ, Danks A, Sommerville E, Walsh J, Bleasel A, Ouvrier R, MacKenzie RA, Manson JI, Bladin PF, Berkovic SF (1993) Corpus callosotomy for intractable epilepsy: seizure outcome and prognostic factors. Epilepsia 34: 904–909
Roberts D (1985) Corpus callosotomy. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 259–267
Roberts DW, Reeves AG, Nordgren RE (1995) The role of posterior callosotomy in patients with suboptimal response to anterior callosotomy. In: Reeves AG, Roberts DW (eds) Epilepsy and the corpus callosum, 2nd ed. Plenum Press, New York, pp 183–190
Roberts DW (1995) Section of the corpus callosum for epilepsy. In: Schmidek HH, Sweet WH (eds) Operative neurosurgical techniques, 3rd edn. WB Saunders Company, Philadelphia, pp 1351–1357
Roberts DW (1998) Corpus callosotomy. In: Engel J, Pedley TA (eds) Epilepsy: a comprehensive textbook. Lippincott-Raven Publishers, Philadelphia, pp 1851–1858
Sass KJ, Spencer DD, Spencer SS, Novelly RA, Williamson PD, Mattson RH (1988) Corpus callosotomy for epilepsy. II. Neurological and neuropsychological outcome. Neurology 38: 24–28
Sass KJ, Novelly RA, Spencer DD, Spencer SS (1990) Postcallosotomy language impairments in patients with crossed cerebral dominance. J Neurosurg 72: 85–90
Schramm J, Behrens E, Entzian W (1992) Hemispherical deaferentation: malformative to functional hemispherectomy. Neurosurgery 36: 509–516
Schwartzkroin PA, Futamach KJ, Noebels JL, Prince DA (1975) Transcallosal effects of a cortical epileptiform focus. Brain Res 99: 59–68
Schwartzkroin PA, Mutani R, Prince DA (1975) Orthodromic and antidromic effects of a cortical epileptiform focus on ventro-lateral nucleus of the cat. J Neurophysiol 38: 795–811
Silverman D (1954) Clinical correlates of the spike-wave complex. Electroencephalogr Clin Neurophysiol 6: 663–669
Smith SJM, Andermann F, Villemure JG, Rasmussen TR, Quesney LF (1991) Functional hemispherectomy: EEG findings, Spiking from isolated brain postoperatively, and prediction of outcome. Neurology 41: 1790–1794
Sorano Vincenzo, Stefano Esposito (1998) Hemispherectomy complications in the light of craniocerebral disproportion: review of the literature and rationale for a filling-reduction cranioplasty. Childs Nerv Syst 14: 440–447
Spencer SS, Spencer DD, Glaser GH (1984) More intensive focal seizure types after callosal section: the role of inhibition. Ann Neurol 16: 686–693
Spencer SS, Gates JR, Reeves AG, Spencer DD, Maxwell RE, Roberts D (1987) Corpus callosum section. In: Engel J (ed) Surgical treatment of epilepsies. Raven Press, New York, pp 425–444
Spencer SS, Spencer DD, Williamson PD, Sass K, Novelly RA, Mattson RH (1988) Corpus callosotomy for epilepsy. I. Seizure effects. Neurology 38: 19–24
Spencer SS, Spencer DD, Sass K, Westerveld M, Katz A, Mattson R (1993) Anterior, total, and two-stage corpus callosum section: differential and incremental seizure responses. Epilepsia 34: 561–567
Spiegel E (1931) The central mechanism of generalized epileptic fits. Am J Psychiatry 88: 595–609
Stavraky GW (1961) Supersensitivity following lesions of the nervous system. University of Toronto Press, Toronto, pp 33–38
Tomasch J (1954) Size, distribution, and number of fibres in the human corpus callosum. Anat Rec 119: 119–135
Traub RD, Miles R (1991) Neuronal networks of the hippocampus. Cambrige University Press, New York, pp 204–222
Trescher HJ, Ford FR (1937) Colloid cyst of the third ventricle. Report of a case; operative removal with section of posterior half of the corpus callosum. Arch Neurol Psychiatry 37: 959–973
Van Wagenen WP, Herren RY (1940) Surgical division of commissural pathways in the corpus callosum. Relation to spread of an epileptic attack. Arch Neurol Psychiatry 44: 740–759
Vergnes M, Marescaux C, Depaulis A, Micheletti G, Warter JM (1990) Spontaneous spike-and-wave discharges in Wistar rats: a model of genetic generalized nonconvulsive epilepsy. In: Avoli M, Gloor P, Kostopoulos G, Naquet R (eds) Generalized epilepsy, neurobiological approaches. Birkhauser, Boston, pp 238–253
Villemure JG, Mascott C, Andermann F, Rasmussen T (1989) Hemispherectomy and the insula. Epilepsia 30: 5
Villemure JG, Rasmussen T (1990) Functional hemispherectomy: methodology. J Epilepsy [Suppl] 3: 177–182
Villemure JG (1992) Hemispherectomy. In: Resor SR and Kutt H (ed) The medical treatment of epilepsy. Marcel Dekker Inc, New York, pp 243–249
Villemure JG (1992b) Hemispherectomy techniques. In: Luders HO (ed) Epilepsy surgery. Raven Press, New York, pp 569–578
Villemure JG, Adams CBT, Hoffman HJ, Peacock WJ (1993) Hemispherectomy. In Engel J (ed) Surgical treatment of the epilepsies. Raven Press, New York, pp 511–518
Villemure JG, Mascott CR (1995) Peri-insular hemispherotomy: surgical principles and anatomy. Neurosurgery 37: 975–981
Villemure JG (1996) Hemispherectomy: techniques and complications. In: Wyllie E (ed) The treatment of epilepsy: principles and practice 2nd edn. Williams and Wilkins, Baltimore, pp 1081–1086
Vining EPG, Freeman JM, Brandt J, Vining Carson BS, Uematsu S (1993) Progressive unilateral encephalopathy of childhood (Rasmussen’s syndrome): a reappraisal. Epilepsia 34: 639–650
Wada JA, Cornelius LR (1960) Functional alteration of deep structures in cats with chronic focal cortical irritative lesions. Arch Neurol 3: 425–447
Wada JA, Sato M (1974) Generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in cats. Correlative electrographic and behavioral features. Neurology 24: 565–574
Wada JA, Sato M (1975) The generalized convulsive seizure state induced by daily electrical stimulation of the amygdala in split brain cats. Epilepsia 16: 417–430
Weenberg RA, Quesney LF, Villemure JG (1997) Epileptiform and nonepileptiform paroxismal activity from isolated cortex after functional hemispherectomy. Electroencephalog Clin Neurophysiol 102: 437–442
White HH (1961) Cerebral hemispherectomy in the treatment of infantile hemiplegia. Conf Neurol 21: 1–50
Wilder BJ, Schmidt RP (1965) Propagation of epileptic discharge from chronic neocortical foci in monkey. Epilepsia 6: 297–309
Williamson PD (1985) Corpus callosum section for intractable epilepsy: criteria for patient selection. In: Reeves AG (ed) Epilepsy and the corpus callosum. Plenum Press, New York, pp 243–257
Wilson DH, Culver C, Waddington M, Gazzaniga MS (1975) Disconnection of the cerebral hemispheres: an alternative to hemispherectomy for the control of intractable seizures. Neurology 25: 1149–1153
Wilson DH, Reeves AG, Gazzaniga MS, Culver C (1977) Cerebral commissurotomy for control of intractable seizures. Neurology 27: 708–715
Wilson DH, Reeves AG, Gazzaniga MS (1978) Division of the corpus callosum for uncontrollable epilepsy. Neurology 28: 649–653
Wilson DH, Reeves AG, Gazzaniga MS (1980) Corpus callosotomy for control of intractable seizures. In: Wada JA, Penry JK (eds) Advances in epileptology. The Xth epilepsy international symposium. Raven Press, New York, pp 205–213
Wilson DH, Reeves AG, Gazzaniga MS (1982) «Central» commissurotomy for intractable generalized epilepsy: series two. Neurology 32: 687–697
Wilson PJE (1970) Cerebral hemispherectomy for infantile hemiplegia. Brain 93: 147–180
Winston KR, Welch K, Adler JR, Erba G (1992) Cerebral hemicoticectomy for epilepsy. J Neurosurgery 77: 889–895
Wyler AR (1997) Corpus callosotomy. In: Wyllie E (ed) The treatment of epilepsy: principles and practice, 2nd edn. Williams & Wilkins, Baltimore, pp 1097–1102
Wyllie E (1988) Corpus callosotomy for intractable generalized epilepsy. J Pediatr 113:255–261
Zentner J (1997) Surgical aspects of corpus callosum section. In: Tuxhorn I, Holthausen H, Boegnik H (eds) Paediatric epilepsy syndromes and their surgical treatment. John Libbey, London, pp 815–829
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer-Verlag/Wien
About this chapter
Cite this chapter
Villemure, JG., Vernet, O., Delalande, O. (2000). Hemispheric Disconnection: Callosotomy and Hemispherotomy. In: Cohadon, F., et al. Advances and Technical Standards in Neurosurgery. Advances and Technical Standards in Neurosurgery, vol 26. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6323-8_2
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6323-8_2
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-3225-8
Online ISBN: 978-3-7091-6323-8
eBook Packages: Springer Book Archive