Summary
Long term administration of the monoamine oxidase inhibitor (—)-deprenyl (0.5mg/Kg) for up to 20 months significantly increased mortality in the male Wistar rat, whereas the dopamine agonist pergolide (0.4mg/Kg) and the antioxidant diethyldithiocarbamate (400mg/Kg) had no significant effect on mortality. The increased mortality was not related to dietary intake or body weight of the rats. This is of interest in the light of recent evidence that (—)-deprenyl increases mortality in humans.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Birkmayer W, Knoll J, Rieder P, Youdim MBH, Hars V, Marton J (1995) Increased life expectancy resulting from L-deprenyl addition to Madopar treatment in Parkinson’s disease: a long term study. J Neural Transm 64: 113–127
Carrillo M-C, Kitani K, Kanai S, Sato Y, Miyasaka K, Ivy GO (1994) The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female Fischer 344 rats. Biochem Pharmacol 47(8): 1333–1338
Kitani K, Kanai S, Sato Y, Ohta, Ivy GO, Carrillo M-C (1992) Chronic treatment of (—)-deprenyl prolongs the life span of male Fischer 344 rats. Further evidence. Life Sci 52: 281–288
Knoll J (1988) The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl. Mech Ageing Dev 46: 237–262
Knoll J (1994) Angiohypotensin. In: Szekebres L, Papp JG (eds) Pharmacology of smooth muscle. Springer, Berlin Heidelberg New York Tokyo (Handbook Exp Pharmacol 111)
Lees AJ (1995) Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson’s disease. BMJ 311: 1602–1607
Milgram NW, Racine RJ, Nellis P, Mendonca A, Ivy GO (1990) Maintenance on L-deprenyl prolongs life in aged rats. Life Sci 47: 415–420
Weindruch R, Walford RL (1988) The retardation of aging and disease by dietary restriction. Charles C. Thomas, Springfield
Yen TT, Knoll J (1992) Extension of life span in mice treated with Dinh lang (Policias fruticosum L) and (-)deprenyl. Acta Physiol Hungarica 79: 119–124
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Wien
About this paper
Cite this paper
Gallagher, I.M., Clow, A., Glover, V. (1998). Long term administration of (—)-deprenyl increases mortality in male Wistar rats. In: Finberg, J.P.M., Youdim, M.B.H., Riederer, P., Tipton, K.F. (eds) MAO — The Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement, vol 52. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6499-0_32
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6499-0_32
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-83037-6
Online ISBN: 978-3-7091-6499-0
eBook Packages: Springer Book Archive