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Long-term Follow-up Results in Hormonally Active Pituitary Adenomas After Primary Successful Transsphenoidal Surgery

  • Conference paper
Processes of the Cranial Midline

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 53))

Summary

The long-term results of transsphenoidal surgery for hormonally active pituitary adenomas were assessed in 3 follow-up studies. Eight out of 50 patients with microprolactinomas developed a persisting postoperative re-increase of prolactin levels during an average follow-up period of 4.1 years. None of the 43 acromegalic patients who had achieved a suppression of growth hormone to below 2ng/ml during an oral glucose load shortly after surgery relapsed. However, when the remission criterion was only based on basal growth hormone below 5 ng/ml 4 out of 61 patients showed a re-increase of growth hormone levels to persistently elevated values during an average follow-up period of 6.1 years. 14 out of 66 patients followed-up for an average of 8.2 years after successful primary microadenomectomy for Cushing’s disease developed recurrent hypercortisolism as documented by an abnormal suppression of Cortisol after oral low dose dexamethasone.

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Authors and Affiliations

  1. Neurochirurgische Klinik mit Poliklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, D-W-8520, Erlangen, Federal Republic of Germany

    Dr. med. M. Buchfelder, R. Fahlbusch, W. Schott & J. Honegger

Authors
  1. Dr. med. M. Buchfelder
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  2. R. Fahlbusch
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  3. W. Schott
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  4. J. Honegger
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Vienna Medical School, Vienna, Austria

    Wolfgang Koos  & Bernd Richling  & 

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© 1991 Springer-Verlag

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Buchfelder, M., Fahlbusch, R., Schott, W., Honegger, J. (1991). Long-term Follow-up Results in Hormonally Active Pituitary Adenomas After Primary Successful Transsphenoidal Surgery. In: Koos, W., Richling, B. (eds) Processes of the Cranial Midline. Acta Neurochirurgica Supplementum, vol 53. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9183-5_13

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  • DOI: https://doi.org/10.1007/978-3-7091-9183-5_13

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9185-9

  • Online ISBN: 978-3-7091-9183-5

  • eBook Packages: Springer Book Archive

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