Summary
The 1/R control was developed to provide control over the output of a total artificial heart (TAH) by the central nervous system by using the peripheral vascular conductance (1/R) the vasodilatation in for the control signal. The physiologic stability of the 1/R control algorithm was tested by using goats with TAH. To apply the 1/R control equation to TAH in goats, real-time and continuous measurements of cardiac output, aortic pressure, and right atrial pressure were performed throughout the survival period. Left atrial pressure was also measured, to prevent lung edema. Under the 1/R control, 532 days’ survival was obtained in a goat with a TAH. Findings over the course of the experiment showed no hemodynamic or metabolic abnormality. Autopsy findings showed macroscopically no congestion in the liver. The experiment demonstrated the physiologic stability of the 1/R control algorithm for an extended period. Improvement of methods for measurement, such as the development of feasible techniques for the noninvasive measurement of the required hemodynamic parameters, will make it possible to use 1/R control in practice, especially for a totally implantable TAH system.
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References
Fujimasa I, Imachi K, Nakajima M, Mabuchi K, Tsukagoshi S, Kouno A, Ono T, Takido N, Motomura K, Chinzei T, Abe Y, Atsumi K (1986) Pathophysiological study of a total artificial heart in a goat that survived for 344 days. In: Nosé Y, Kjellstrand C, Ivanovich P (eds) Progress in artificial organs — 1985 ISAO, Cleveland, pp 345–353
Abe Y, Imachi K, Chinzei T, Mabuchi K, Imanishi K, Isoyama T, Yonezawa T, Kouno A, Ono T, Atsumi K, Fujimasa I (1993) Reciprocal of peripheral vascular resistance (1/R) control method for total artificial heart. In: Akutsu T, Koyanagi H (eds) Artificial heart 4. Springer, Tokyo, pp 349–351
Abe Y, Chinzei T, Imachi K, Mabuchi K, Imanishi K, Isoyama T, Matsuura H, Senih G, Nozawa H, Kouno A, Ono T, Atsumi K, Fujimasa I (1994) Can total artificial heart animals control their TAH by themselves? One year survival of a TAH goat using a new automatic control method (1/R control). ASAIO J 40:M506–M509
Atsumi K, Fujimasa I, Imachi K, Nakajima M, Tsukagoshi S, Mabuchi K, Motomura K, Kohno A, Ono T, Miyamoto A, Takido N, Inou N (1985) Long-term heart substitution with an artificial heart in goats. ASAIO J 8:155–165
Yoshizawa M, Takeda H, Yambe Y, Nitta S, Abe Y, Isoyama T, Imachi K, Chinzei T, Fujimasa I (1994) Development of optimal operating point controller for implantable total artificial heart. Jpn J Artif Organs 23:551–558
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© 1998 Springer-Verlag Tokyo
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Abe, Y. et al. (1998). Over 500 Days’ Survival of a Goat with a Total Artificial Heart with 1/R Control. In: Akutsu, T., Koyanagi, H. (eds) Heart Replacement. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65921-1_6
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DOI: https://doi.org/10.1007/978-4-431-65921-1_6
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-65923-5
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