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Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells

  • Chapter
Allergy Frontiers: Classification and Pathomechanisms

Part of the book series: Allergy Frontiers ((ALLERGY,volume 2))

Abstract

Siglec-8, the eighth member of the sialic acid-binding, immunoglobulin [Ig]-like lectin family, was initially discovered as a cell surface protein selectively expressed on human eosinophils. It is now know to also be expressed by mast cells and basophils. Siglec-8 engagement with specific antibodies causes apoptosis via caspase and mitochondrial-dependent pathways. For mast cells, inhibition of mediator release, but no apoptosis, is observed. Siglec-F is the closest mouse paralog to Siglec-8, and both selectively bind the sulfated glycan 6’-sulfo-sialyl Lewis X. Antibodies to Siglec-F reduce blood and tissue eosinophil numbers in vivo. This suggests that Siglec-8 may be a useful future therapeutic target for allergic and other eosinophilic disorders.

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  1. Division of Allergy & Clinical Immunology, Johns Hopkins Asthma & Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224-6821, USA

    Stephan von Gunten & Bruce S. Bochner

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  1. Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan

    Ruby Pawankar

  2. Southampton General Hospital, University of Southampton, Tremona Road, Southampton, UK

    Stephen T. Holgate

  3. Childrens's Mercy Hospital and Clinic, UMKC School of Medicine, 2401 Gillham Road, Kansas City, MO, 64108, USA

    Lanny J. Rosenwasser

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Gunten, S.v., Bochner, B.S. (2009). Expression and Function of Siglec-8 in Human Eosinophils, Basophils, and Mast Cells. In: Pawankar, R., Holgate, S.T., Rosenwasser, L.J. (eds) Allergy Frontiers: Classification and Pathomechanisms. Allergy Frontiers, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-88315-9_19

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