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Calcium and Endothelium-Mediated Vasodilator Signaling

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Vascular tone refers to the balance between arterial constrictor and dilator activity. The mechanisms that underlie tone are critical for the control of haemodynamics and matching circulatory needs with metabolism, and thus alterations in tone are a primary factor for vascular disease etiology. The dynamic spatiotemporal control of intracellular Ca2+ levels in arterial endothelial and smooth muscle cells facilitates the modulation of multiple vascular signaling pathways. Thus, control of Ca2+ levels in these cells is integral for the maintenance of tone and blood flow, and intimately associated with both physiological and pathophysiological states. Hence, understanding the mechanisms that underlie the modulation of vascular Ca2+ activity is critical for both fundamental knowledge of artery function, and for the development of targeted therapies. This brief review highlights the role of Ca2+ signaling in vascular endothelial function, with a focus on contact-mediated vasodilator mechanisms associated with endothelium-derived hyperpolarization and the longitudinal conduction of responses over distance.

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Authors and Affiliations

  1. Department of Physiology, School of Medical Sciences, University of New South Wales, 2052, Sydney, NSW, Australia

    Shaun L. Sandow, Sevvandi Senadheera, T. Hilton Grayson & Timothy V. Murphy

  2. Department of Pharmacology, School of Medical Sciences, University of New South Wales, 2052, Sydney, NSW, Australia

    Shaun L. Sandow, Sevvandi Senadheera & T. Hilton Grayson

  3. Smooth Muscle Research Group and Physiology and Biophysics, University of Calgary, Calgary, AB, Canada

    Don G. Welsh

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  1. Shaun L. Sandow
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  2. Sevvandi Senadheera
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  3. T. Hilton Grayson
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  4. Don G. Welsh
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  5. Timothy V. Murphy
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Correspondence to Shaun L. Sandow .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Sandow, S.L., Senadheera, S., Grayson, T.H., Welsh, D.G., Murphy, T.V. (2012). Calcium and Endothelium-Mediated Vasodilator Signaling. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_36

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