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The Dynamics of Neuronal Migration

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Cellular and Molecular Control of Neuronal Migration

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 800))

Abstract

Proper lamination of the cerebral cortex is precisely orchestrated, especially when neurons migrate from their place of birth to their final destination. The consequences of failure or delay in neuronal migration cause a wide range of disorders, such as lissencephaly, schizophrenia, autism and mental retardation. Neuronal migration is a dynamic process, which requires dynamic remodeling of the cytoskeleton. In this context microtubules and microtubule-related proteins have been suggested to play important roles in the regulation of neuronal migration. Here, we will review the dynamic aspects of neuronal migration and brain development, describe the molecular and cellular mechanisms of neuronal migration and elaborate on neuronal migration diseases.

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Authors and Affiliations

  1. Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China

    Qian Wu, Jing Liu, Ai Fang, Rui Li, Ye Bai & Xiaoqun Wang

  2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, 35 Medical Center Way, San Francisco, CA, 94143, USA

    Arnold R. Kriegstein

  3. Department of Neurology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA, 94143, USA

    Arnold R. Kriegstein

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  1. Qian Wu
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Correspondence to Xiaoqun Wang .

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  1. GIGA-Neurosciences, University of Liège, Liège, Belgium

    Laurent Nguyen

  2. Institute of Science and Technology Austria, Klosterneuburg, Niederösterreich, Austria

    Simon Hippenmeyer

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Wu, Q. et al. (2014). The Dynamics of Neuronal Migration. In: Nguyen, L., Hippenmeyer, S. (eds) Cellular and Molecular Control of Neuronal Migration. Advances in Experimental Medicine and Biology, vol 800. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7687-6_2

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