Abstract
Many ocular diseases are reported to produce a sensitivity loss for specific achromatic or chromatic pathways, particularly short-wavelength-sensitive cone (S-cone) pathways. To study these losses we have measured VECPs using spatio-chromatic stimuli which vary along directions in the color space proposed by MacLeod & Boynton (1978) and augmented by Krauskopf et al. (1982). Such stimuli, by maintaining the same time-averaged luminance and chrominance, avoid the complications of chromatic adaptation while allowing selective activation of various pathways. We report how this technique can be used to analyze selective sensitivity loss in retinal disease. Specifically, we studied losses in a subject with a history of central serous choroidopathy. VECPs elicited from stimulation of the affected eye are compared with those elicited from the unaffected eye and with responses from normal subjects. For the affected eye we find that response amplitudes for 1 c/deg gratings modulated along the S axis are greatly reduced compared to those from the unaffected eye and for normals. No interocular response difference is observed for stimuli which vary along the L-M, L or M axes or for luminance modulated stimuli. Comparison of VECPs evoked by S axis modulation between different retinal regions of the affected eye reveals a regional loss. The results illustrate how these techniques can reveal selective losses in ocular disease.
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Crognale, M.A., Rabin, J., Switkes, E., Adams, A.J. (1993). Selective loss of S-pathway sensitivity in central serous choroidopathy revealed by spatio-chromatic visual evoked cortical potentials (VECP). In: Drum, B. (eds) Colour Vision Deficiencies XI. Documenta Ophthalmologica Proceedings Series, vol 56. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1856-9_23
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DOI: https://doi.org/10.1007/978-94-011-1856-9_23
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