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Apoptosis induced by a novel Ruthenium II complex in a Gallbladder carcinoma cell line

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VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016

Part of the book series: IFMBE Proceedings ((IFMBE,volume 60))

Abstract

Some metals with striking properties have been used for the development of different complexes with activity against malignant cells. Due to difficulties in early diagnosis of gallbladder cancer (GBC) the main treatment option is chemotherapy. In this line of research, ruthenium complexes represent a less toxic alternative that others metal complexes such as cisplatin. The aim of this study was to evaluate the effect of a novel ruthenium complex in activation of apoptosis in a cell lineG-415. Our results show an activity of inducing cell death and over-expression of pro-apoptotic transcripts.

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Author information

Authors and Affiliations

  1. Ciencias Biomédicas, Facultad de Medicina, Universidad Católica Del Norte, Coquimbo, Chile

    Hernán Villota

  2. Facultad de Ciencias Exactas y Aplicadas- GI2B, Instituto Tecnológico Metropolitano, Medellín, Colombia

    Hernán Villota, Fabián Cortés-Mancera & Giuliano Bernal

  3. Departamento de Química, Facultad de Ciencias, Universidad de La Serena, Serena, Chile

    Sebastian Pizarro, Francisco Gajardo & Álvaro Delgadillo

Authors
  1. Hernán Villota
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  2. Sebastian Pizarro
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  3. Francisco Gajardo
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  4. Álvaro Delgadillo
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  5. Fabián Cortés-Mancera
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  6. Giuliano Bernal
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Corresponding author

Correspondence to Hernán Villota .

Editor information

Editors and Affiliations

  1. Asociación Colombiana de Bioingeniería y Electrónica Médica - ABIOIN, Bucamaranga, Colombia

    Isnardo Torres

  2. Universidad Pontificia Bolivariana - UPB, Centro de Bioingeniería, Medellín, Colombia

    John Bustamante

  3. Universidad Industrial de Santander, Escuela de Ing. Eléctrica, Electrónica, Bucaramanga, Colombia

    Daniel A. Sierra

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© 2017 Springer Nature Singapore Pte Ltd.

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Villota, H., Pizarro, S., Gajardo, F., Delgadillo, Á., Cortés-Mancera, F., Bernal, G. (2017). Apoptosis induced by a novel Ruthenium II complex in a Gallbladder carcinoma cell line. In: Torres, I., Bustamante, J., Sierra, D. (eds) VII Latin American Congress on Biomedical Engineering CLAIB 2016, Bucaramanga, Santander, Colombia, October 26th -28th, 2016. IFMBE Proceedings, vol 60. Springer, Singapore. https://doi.org/10.1007/978-981-10-4086-3_75

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  • DOI: https://doi.org/10.1007/978-981-10-4086-3_75

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-4085-6

  • Online ISBN: 978-981-10-4086-3

  • eBook Packages: EngineeringEngineering (R0)

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