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Circulating Exosomes in Cardiovascular Diseases

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Exosomes in Cardiovascular Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 998))

Abstract

Circulating exosomes could arrive in distant tissues via blood circulation, thus directly communicating with target cells and rapidly regulating intracellular signalings. Circulating exosomes and exosomal cargos are critically involved in cardiovascular pathophysiology, such as cardiomyocyte hypertrophy, apoptosis, and angiogenesis. Circulating exosomes enriched with various types of biological molecules can be changed not only in the number but also in the composite cargos upon cardiac injury, such as myocardial infarction, myocardial ischemia reperfusion injury, atherosclerosis, hypertension, and sepsis cardiomyopathy, which may further influence cardiomyocyte function and contribute to the pathogenesis of cardiovascular diseases. Thus, exosome-based therapeutic strategy may be used to attenuate myocardial injury and promote cardiac regeneration and repair. Also, more preclinical and clinical studies would be needed to investigate the potential of circulating exosomes as biomarkers for the diagnosis, risk stratification, and prognosis of cardiovascular diseases.

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Acknowledgements

This work was supported by the grants from National Natural Science Foundation of China (81570362, 91639101 and 81200169 to JJ Xiao and 81400647 to Y Bei), and the development fund for Shanghai talents (to JJ Xiao).

Competing Financial Interests The authors declare no competing financial interests.

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Authors and Affiliations

  1. Cardiac Regeneration and Ageing Lab, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China

    Yihua Bei & Junjie Xiao

  2. Laboratory for Advanced Interdisciplinary Research, Center for Personalized Medicine/Institutes of Translational Medicine, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, China

    Ting Chen

  3. Research Beyond Limits SRL, 15 Dimitrie Cantemir Blvd., Bl.9, Sc.C, Ap.107, Sector 4, 040234, Bucharest, Romania

    Daniel Dumitru Banciu

  4. University of Bucharest, 36-46 Mihail. Kogălniceanu Bld., Sector 5, 050107, Bucharest, Romania

    Daniel Dumitru Banciu

  5. Victor Babes National Institute of Pathology, Bucharest, 050096, Romania

    Dragos Cretoiu

  6. Division of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania

    Dragos Cretoiu

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  1. Yihua Bei
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  2. Ting Chen
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  3. Daniel Dumitru Banciu
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  4. Dragos Cretoiu
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  5. Junjie Xiao
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Corresponding author

Correspondence to Junjie Xiao .

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Editors and Affiliations

  1. Shanghai University , Shanghai, China

    Junjie Xiao

  2. Victor BabeÅŸ National Institute of Patho , Bucharest, Romania

    Sanda Cretoiu

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Bei, Y., Chen, T., Banciu, D.D., Cretoiu, D., Xiao, J. (2017). Circulating Exosomes in Cardiovascular Diseases. In: Xiao, J., Cretoiu, S. (eds) Exosomes in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 998. Springer, Singapore. https://doi.org/10.1007/978-981-10-4397-0_17

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