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Genetic Advance in Depressive Disorder

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Depressive Disorders: Mechanisms, Measurement and Management

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1180))

Abstract

Major depressive disorder (MDD) and bipolar disorder (BPD) are both chronic, severe mood disorder with high misdiagnosis rate, leading to substantial health and economic burdens to patients around the world. There is a high misdiagnosis rate of bipolar depression (BD) just based on symptomology in depressed patients whose previous manic or mixed episodes have not been well recognized. Therefore, it is important for psychiatrists to identify these two major psychiatric disorders. Recently, with the accumulation of clinical sample sizes and the advances of methodology and technology, certain progress in the genetics of major depression and bipolar disorder has been made. This article reviews the candidate genes for MDD and BD, genetic variation loci, chromosome structural variation, new technologies, and new methods.

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Acknowledgements

Parts of the contents in this chapter were reused from the articles (Maturana et al. 2015; Zant et al. 2011) with permissions.

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  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Chen Zhang

  2. Department of Psychiatry, Shenzhen Kangning Hospital, Shenzhen, Guangdong, China

    Han Rong

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  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai, China

    Yiru Fang

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Zhang, C., Rong, H. (2019). Genetic Advance in Depressive Disorder. In: Fang, Y. (eds) Depressive Disorders: Mechanisms, Measurement and Management. Advances in Experimental Medicine and Biology, vol 1180. Springer, Singapore. https://doi.org/10.1007/978-981-32-9271-0_2

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